師資
個(gè)人簡(jiǎn)介：
夏思源，2014年畢業(yè)于南開大學(xué)，獲得生物化學(xué)與分子生物學(xué)博士學(xué)位。畢業(yè)后赴美國(guó)Emory大學(xué)醫(yī)學(xué)院血液與醫(yī)學(xué)腫瘤學(xué)系進(jìn)行博士后工作，后晉升為Associate Research Scientist。2021年8月全職回國(guó)，加入南方科技大學(xué)醫(yī)學(xué)院，任助理教授，博士生導(dǎo)師。研究方向主要集中于腫瘤代謝與腫瘤免疫領(lǐng)域，研究?jī)?nèi)容主要包括代謝物在腫瘤微環(huán)境中的作用，腫瘤代謝通路的調(diào)節(jié)與靶向。在生物化學(xué)，分子生物學(xué)，腫瘤細(xì)胞生物學(xué)與免疫學(xué)方面具有深厚的專業(yè)基礎(chǔ)。截止目前，已在Cell Metabolism、Cancer Discovery、Molecular Cell、Journal of Immunology等高水平國(guó)際期刊發(fā)表論文24篇，總引用近800余次，并獲得專利1項(xiàng)。同時(shí)，作為審稿人多次為Journal of Cellular Physiology，Journal of Genetics and Genomics，Scientific Reports和Oncotarget等雜志審稿。未來的研究將主要聚焦于代謝物對(duì)腫瘤微環(huán)境的調(diào)控，構(gòu)建綜合性代謝物文庫，篩選調(diào)控腫瘤細(xì)胞、免疫細(xì)胞與基質(zhì)細(xì)胞相互作用的代謝物，明確其作用機(jī)制及靶向策略，探討其與免疫治療的聯(lián)合應(yīng)用。
教育背景：
2005.9 ~ 2009.6: 南開大學(xué)，生物科學(xué)，本科
2009.9 ~ 2014.6: 南開大學(xué)，生物化學(xué)與分子生物學(xué)，直博
工作經(jīng)歷：
2014.9 ~ 2019.8: 美國(guó)Emory大學(xué)，血液與醫(yī)學(xué)腫瘤學(xué)系，博士后
2019.9 ~ 2021.1: 美國(guó)Emory大學(xué)，血液與醫(yī)學(xué)腫瘤學(xué)系， Associate Research Scientist
2021.8 ~ 至今： 南方科技大學(xué)，醫(yī)學(xué)院，人類細(xì)胞生物和遺傳學(xué)系，助理教授
研究領(lǐng)域：
1. 代謝物作為信號(hào)分子對(duì)腫瘤細(xì)胞的調(diào)控作用
2. 腫瘤轉(zhuǎn)移灶的代謝微環(huán)境以及對(duì)腫瘤細(xì)胞與免疫細(xì)胞的影響
3. 代謝物作為潛在靶點(diǎn)與腫瘤免疫治療的聯(lián)合應(yīng)用
學(xué)術(shù)任職：
2018 至今：美國(guó)癌癥研究協(xié)會(huì)（AACR）, Associate Member
2017 至今：美國(guó)血液學(xué)會(huì)（ASH）， Associate Member
發(fā)表論文： *共同第一作者，#共同通訊作者
Xue Gao, Yijie Liu, Yuancheng Li, Hao Fan, Rong Wu, Rukang Zhang, Brandon Faubert, Yu-Ying He, Marc B. Bissonnette, Siyuan Xia, Dong Chen, Hui Mao, Titus J. Boggon, and Jing Chen. Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation. Molecular cell, Molecular cell, S1097-2765(22)00264-7. 7 Apr. 2022, doi:10.1016/j.molcel.2022.03.026 (2022).
Siyuan Xia, Ruiting Lin, Lingtao Jin, Liang Zhao, Hee-Bum Kang, Yaozhu Pan, Shuangping Liu, Guoqing Qian, Zhiyu Qian, Evmorfia Konstantakou, Baotong Zhang, Jin-Tang Dong, Young Rock Chung, Omar Abdel-Wahab, Taha Merghoub, Lu Zhou, Ragini R. Kudchadkar, David H. Lawson, Hanna J. Khoury, Fadlo R. Khuri, Lawrence H. Boise, Sagar Lonial, Benjamin H. Lee, Brian P. Pollack, Jack L. Arbiser, Jun Fan, Qun-Ying Lei & Jing Chen. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metab 25, 358-373, doi:10.1016/j.cmet.2016.12.010 (2017).
Dong Chen*, Siyuan Xia*, Mei Wang*, Ruiting Lin, Yuancheng Li, Hui Mao, Mike Aguiar, Christopher A. Famulare, Alan H. Shih, Cameron W. Brennan, Xue Gao, Yaozhu Pan, Shuangping Liu, Jun Fan, Lingtao Jin, Lina Song, An Zhou, Joydeep Mukherjee, Russell O. Pieper, Ashutosh Mishra, Junmin Peng, Martha Arellano, William G. Blum, Sagar Lonial, Titus J. Boggon, Ross L. Levine#, Jing Chen#. Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. Cancer Discov, doi:10.1158/2159-8290.CD-18-1040 (2019).
Dong Chen*, Siyuan Xia*, Rukang Zhang*, Yuancheng Li, Christopher A. Famulare, Hao Fan, Rong Wu, Mei Wang, Allen C. Zhu, Shannon E. Elf, Rui Su, Lei Dong, Martha Arellano, William G. Blum, Hui Mao, Sagar Lonial, Wendy Stock, Olatoyosi Odenike, Michelle Le Beau, Titus J. Boggon, Chuan He, Jianjun Chen, Xue Gao#, Ross L. Levine#, and Jing Chen#. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Mol Cell, 81, 1-15, doi: 10.1016/j.molcel.2021.06.027 (2021)
Siyuan Xia*, Jun Wei*, Jingya Wang, Huayan Sun, Wenting Zheng, Yangguang Li, Yanbo Sun, Huiyuan Zhao, Song Zhang, Ti Wen, Xinglong Zhou, Jian-Xin Gao, Puyue Wang, Zhenzhou Wu, Liqing Zhao, Zhinan Yin. A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells. J Leukoc Biol 95, 733-742, doi:10.1189/jlb.0713371 (2014).
Jun Wei*, Siyuan Xia*, Huayan Sun, Song Zhang, Jingya Wang, Huiyuan Zhao, Xiaoli Wu, Xi Chen, Jianlei Hao, Xinglong Zhou, Zhengmao Zhu, Xiang Gao, Jian-Xin Gao, Puyue Wang, Zhenzhou Wu, Liqing Zhao, Zhinan Yin. Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells. J Immunol 191, 500-508, doi:10.4049/jimmunol.1300328 (2013).
Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei-Ping Qian, Lily Yang, Adeboye O. Osunkoya, Lawrence H. Boise, Paula M. Vertino, Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Jin-Tang Dong. Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer. Nat Commun. 12, 1714, doi: 10.1038/s41467-021-21976-w (2021).
Baotong Zhang,Siyuan Xia, Mingcheng Liu, Xiawei Li, Shimin Shuai, Wei Tao, Yixiang Li, Jianping Jenny Ni, Wei Zhou, Lan Liao, Jianming Xu, Jin-Jang Dong. Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling. Journal of genetics and genomics 21, doi:10.1016/j.jgg.2021.11.013 (2021).
Baotong Zhang, Xinpei Ci, Ran Tao, Jianping Jenny Ni, Xiaoyan Xuan, Jamie L. King, Siyuan Xia, Yixiang Li, Henry F. Frierson, Dong-Kee Lee, Jianming Xu, Adeboye O. Osunkoya, Jin-Tang Dong. Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration. Nat Commun 11, 997, doi:10.1038/s41467-020-14737-8 (2020).
Yixiang Li, Baotong Zhang#, Lingwei Xiang, Siyuan Xia, Omer Kucuk, Xingming Deng, Lawrence H. Boise, Jin-Tang Dong#. TGF-beta causes Docetaxel resistance in Prostate Cancer via the induction of Bcl-2 by acetylated KLF5 and Protein Stabilization. Theranostics 10, 7656-7670, doi:10.7150/thno.44567 (2020).
Yuancheng Li, Hui Wu, Bing Ji, Weiping Qian, Siyuan Xia, Liya Wang, Yaolin Xu, Jing Chen, Lily Yang, Hui Mao. Targeted Imaging of CD206 Expressing Tumor-Associated M2-like Macrophages Using Mannose-Conjugated Antibiofouling Magnetic Iron Oxide Nanoparticles. ACS Applied Bio Materials 3, 4335-4347, doi:10.1021/acsabm.0c00368 (2020).
Xue Gao*, Liang Zhao*, Shuangping Liu*, Yuancheng Li, Siyuan Xia, Dong Chen, Mei Wang, Shaoxiong Wu, Qing Dai, Hieu Vu, Lauren Zacharias, Ralph DeBerardinis, Esther Lim, Christian Metallo, Titus J. Boggon, Sagar Lonial, Ruiting Lin, Hui Mao, Yaozhu Pan, Changliang Shan, Jing Chen. gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell 76, 857- 871 e859, doi:10.1016/j.molcel.2019.09.007 (2019).
Ran Tao*, Baotong Zhang*, Yixiang Li, Jamie L. King, Ruoyu Tian, Siyuan Xia, Cara Rae Schiavon, Jin-Tang Dong. HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation. Biochem Biophys Res Commun 500, 777-782, doi:10.1016/j.bbrc.2018.04.153 (2018).
Ruiting Lin, Siyuan Xia, Changliang Shan, Dong Chen, Yijie Liu, Xue Gao, Mei Wang, Hee-Bum Kang, Yaozhu Pan, Shuangping Liu, Young Rock Chung, Omar Abdel-Wahab, Taha Merghoub, Michael Rossi, Ragini R. Kudchadkar, David H. Lawson, Fadlo R. Khuri, Sagar Lonial, Jing Chen. The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells. Mol Cell 69, 923-937, doi:10.1016/j.molcel.2018.02.010 (2018).
Liang Zhao, Jun Fan, Siyuan Xia, Yaozhu Pan, Shuangping Liu, Guoqing Qian, Zhiyu Qian, Hee-Bum Kang, Jack L. Arbiser, Brian P. Pollack, Ragini R. Kudchadkar, David H. Lawson, Michael Rossi, Omar Abdel-Wahab, Taha Merghoub, Hanna J. Khoury, Fadlo R. Khuri, Lawrence H. Boise, Sagar Lonial, Fangping Chen#, Jing Chen#, Ruiting Lin. HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers. J Biol Chem 292, 10142-10152, doi:10.1074/jbc.M117.788778 (2017).
Shannon Elf*, Ruiting Lin*, Siyuan Xia, Yaozhu Pan, Changliang Shan, Shaoxiong Wu, Sagar Lonial, Manila Gaddh, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Titus J. Boggon, Jun Fan, Jing Chen. Targeting 6- phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene 36, 254-262, doi:10.1038/onc.2016.196 (2017).
Qian Zhang, Jian Mao, Xiaoxi Zhang, Haifeng Fu, Siyuan Xia, Zhinan Yin, Lin Liu. Role of Jnk1 in development of neural precursors revealed by iPSC modeling. Oncotarget 7, 60919-60928, doi:10.18632/oncotarget.11377 (2016).
Jun Fan*#, Ruiting Lin*, Siyuan Xia, Dong Chen, Shannon E. Elf, Shuangping Liu, Yaozhu Pan, Haidong Xu, Zhiyu Qian, Mei Wang, Changliang Shan, Lu Zhou, Qun-Ying Lei, Yuancheng Li, Hui Mao, Benjamin H. Lee, Jessica Sudderth, Ralph J. DeBerardinis, Guojing Zhang, Taofeek Owonikoko, Manila Gaddh, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Sumin Kang, Paul W. Doetsch, Sagar Lonial, Titus J. Boggon, Walter J. Curran, Jing Chen#. Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth. Mol Cell 64, 859-874, doi:10.1016/j.molcel.2016.10.014 (2016).
Xin Li, Baotong Zhang, Qiao Wu, Xinpei Ci, Ranran Zhao, Zhiqian Zhang, Siyuan Xia, Dan Su, Jie Chen, Gui Ma, Liya Fu, Jin-Tang Dong. Interruption of KLF5 acetylation converts its funciton from tumor suppressor to tumor promoter in prostate cancer cells. Int J Cancer 136, 536-546, doi:10.1002/ijc.29028 (2015).
Song Zhang, Ruifang Liang, Wei Luo, Chang Liu, Xiaoli Wu, Yanan Gao, Jianlei Hao, Guangchao Cao, Xi Chen, Jun Wei, Siyuan Xia, Zheng Li, Ti Wen, Yunyun Wu, Xinglong Zhou, Puyue Wang, Liqing Zhao, Zhenzhou Wu, Sidong Xiong, Xiaoming Gao, Xiang Gao, Yongyan Chen, Qing Ge, Zhigang Tian, Zhinan Yin. High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-gamma dysregulation of CD4+ T cells. Hepatology 57, 1620- 1631, doi:10.1002/hep.26166 (2013).
Baotong Zhang, Zhiqian Zhang, Siyuan Xia, Changsheng Xing, Xinpei Ci, Xin Li, Ranran Zhao, Sha Tian, Gui Ma, Zhengmao Zhu, Liya Fu, Jin-Tang Dong. KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells. Mol Cell Biol 33, 4919-4935, doi:10.1128/MCB.00787-13 (2013).
Xiaoli Wu*, Ji-Yuan Zhang*, Ang Huang, Yuan-Yuan Li, Song Zhang, Jun Wei, Siyuan Xia, Yajuan Wan, Weiwei Chen, Zheng Zhang, Yangguang Li, Ti Wen, Yan Chen, Yoshimasa Tanaka, Youjia Cao, Puyue Wang, Liqing Zhao, Zhenzhou Wu, Fu-Sheng Wang, Zhinan Yin. Decreased V delta 2 gamma delta T cells associated with liver damage by regulation of Th17 response in patients with chronic hepatitis B. J Infect Dis 208, 1294-1304, doi:10.1093/infdis/jit312 (2013).
Yangguang Li, Ti Wen, Minzhi Zhu, Lixin Li, Jun Wei, Xiaoli Wu, Mingzhou Guo, Shuangping Liu, Huiyuan Zhao, Siyuan Xia, Weili Huang, Puyue Wang, Zhenzhou Wu, Liqing Zhao, Wenqing Shui#, Zheng Li#, Zhinan Yin#. Glycoproteomic analysis of tissues from patients with colon cancer using lectin microarrays and nanoLC-MS/MS. Mol Biosyst 9, 1877-1887, doi:10.1039/c3mb00013c (2013).
Jianlei Hao, Siyuan Dong, Siyuan Xia, Weifeng He, Hao Jia, Song Zhang, Jun Wei, Rebecca L. O’Brien, Willi K. Born, Zhenzhou Wu, Puyue Wang, Jihong Han, Zhangyong Hong, Liqing Zhao, Zhinan Yin. Regulatory role of Vgamma1 gammadelta T cells in tumor immunity through IL-4 production. J Immunol 187, 4979-4986, doi:10.4049/jimmunol.1101389 (2011).
Jianlei Hao, Xiaoli Wu, Siyuan Xia, Zheng Li, Ti Wen, Na Zhao, Zhenzhou Wu, Puyue Wang, Liqing Zhao, Zhinan Yin. Current progress in gammadelta T-cell biology. Cell Mol Immunol 7, 409-413, doi:10.1038/cmi.2010.50 (2010).