Faculty
SELF-INTRODUCTION：
Dr. Siyuan Xia graduated from Nankai University in major of Biochemistry and Molecular Biology in 2014. After graduation, she started to work at Emory University, School of Medicine, Department of Hematology and Medical Oncology as a Postdoctoral Fellow, and then promoted to be an Associate Research Scientist. She joined SUStech University and became a tenure-track Assistant Professor since August 2021. Her research interest focuses on cancer metabolism and cancer immunology, including metabolite functions in tumor microenvironment and cancer therapeutic strategies targeting metabolic pathways. She is well-experienced in the research of biochemistry, molecular biology, cancer cell biology and immunology. Dr. Xia has published 24 papers on high-profile journals (i.e., Cell Metabolism、Cancer Discovery、Molecular Cell、Journal of Immunology) and been authorized an US patent. Her future research will still focus on metabolite functions in tumor microenvironment, generate metabolite library, screen out metabolites which regulate the interactions between cancer cells and immune cells, study the underline mechanism and the combination strategies with cancer immunotherapies.
EDUCATION:
2009.9 ~ 2014.6: Ph.D. major in Biochemistry and Molecular biology, College of Life Sciences, Nankai University, Tianjin, China; (Mentor: Dr. Zhinan Yin)
2005.9 ~ 2009.6: B.Sc. major in Biological Sciences, College of Life Sciences, Nankai University, Tianjin, China; (Mentor: Dr. Zhinan Yin)
WOKRING EXPERIENCE:
2021.8 ~ present: tenure-track Assistant Professor of Department of Human Cell Biology and Genetics, Sustech University School of Medicine, Shenzhen, Guangdong, China
2019.9 ~ 2021.1: Associate Research Scientist of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory, Atlanta, Georgia, USA
2014.9 ~ 2019.8: Postdoctoral Fellow of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory, Atlanta, Georgia, USA (Mentor: Dr. Jing Chen)
RESEARCH:
1. Metabolite functions on tumor cells as signaling molecules.
2. How tumor cells and immune cells adjust to metastatic tumor metabolic microenvironment.
3. Metabolites work as potential targets and combination strategies with cancer immunotherapies.
MANUSCRIPT REVIEWER AND EDITOR：
2020 Reviewer, Journal of Cellular Physiology
2017 Reviewer, Journal of Genetics and Genomics
2016 Reviewer, Scientific Reports
2016 Reviewer, Oncotarget
PUBLICATIONS： *co-first authors, #co-corresponding authors
Siyuan Xia, Ruiting Lin, Lingtao Jin, Liang Zhao, Hee-Bum Kang, Yaozhu Pan, Shuangping Liu, Guoqing Qian, Zhiyu Qian, Evmorfia Konstantakou, Baotong Zhang, Jin-Tang Dong, Young Rock Chung, Omar Abdel-Wahab, Taha Merghoub, Lu Zhou, Ragini R. Kudchadkar, David H. Lawson, Hanna J. Khoury, Fadlo R. Khuri, Lawrence H. Boise, Sagar Lonial, Benjamin H. Lee, Brian P. Pollack, Jack L. Arbiser, Jun Fan, Qun-Ying Lei & Jing Chen. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metab 25, 358-373, doi:10.1016/j.cmet.2016.12.010 (2017).
Dong Chen*, Siyuan Xia*, Mei Wang*, Ruiting Lin, Yuancheng Li, Hui Mao, Mike Aguiar, Christopher A. Famulare, Alan H. Shih, Cameron W. Brennan, Xue Gao, Yaozhu Pan, Shuangping Liu, Jun Fan, Lingtao Jin, Lina Song, An Zhou, Joydeep Mukherjee, Russell O. Pieper, Ashutosh Mishra, Junmin Peng, Martha Arellano, William G. Blum, Sagar Lonial, Titus J. Boggon, Ross L. Levine#, Jing Chen#. Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. Cancer Discov, doi:10.1158/2159-8290.CD-18-1040 (2019).
Dong Chen*, Siyuan Xia*, Rukang Zhang*, Yuancheng Li, Christopher A. Famulare, Hao Fan, Rong Wu, Mei Wang, Allen C. Zhu, Shannon E. Elf, Rui Su, Lei Dong, Martha Arellano, William G. Blum, Hui Mao, Sagar Lonial, Wendy Stock, Olatoyosi Odenike, Michelle Le Beau, Titus J. Boggon, Chuan He, Jianjun Chen, Xue Gao#, Ross L. Levine#, and Jing Chen#. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Mol Cell, 81, 1-15, doi: 10.1016/j.molcel.2021.06.027 (2021)
Siyuan Xia*, Jun Wei*, Jingya Wang, Huayan Sun, Wenting Zheng, Yangguang Li, Yanbo Sun, Huiyuan Zhao, Song Zhang, Ti Wen, Xinglong Zhou, Jian-Xin Gao, Puyue Wang, Zhenzhou Wu, Liqing Zhao, Zhinan Yin. A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells. J Leukoc Biol 95, 733-742, doi:10.1189/jlb.0713371 (2014).
Jun Wei*, Siyuan Xia*, Huayan Sun, Song Zhang, Jingya Wang, Huiyuan Zhao, Xiaoli Wu, Xi Chen, Jianlei Hao, Xinglong Zhou, Zhengmao Zhu, Xiang Gao, Jian-Xin Gao, Puyue Wang, Zhenzhou Wu, Liqing Zhao, Zhinan Yin. Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells. J Immunol 191, 500-508, doi:10.4049/jimmunol.1300328 (2013).
Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei-Ping Qian, Lily Yang, Adeboye O. Osunkoya, Lawrence H. Boise, Paula M. Vertino, Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Jin-Tang Dong. Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer. Nat Commun. 12, 1714, doi: 10.1038/s41467-021-21976-w (2021).
Baotong Zhang,Siyuan Xia, Mingcheng Liu, Xiawei Li, Shimin Shuai, Wei Tao, Yixiang Li, Jianping Jenny Ni, Wei Zhou, Lan Liao, Jianming Xu, Jin-Jang Dong. Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling. Journal of genetics and genomics 21, doi:10.1016/j.jgg.2021.11.013 (2021).
Baotong Zhang, Xinpei Ci, Ran Tao, Jianping Jenny Ni, Xiaoyan Xuan, Jamie L. King, Siyuan Xia, Yixiang Li, Henry F. Frierson, Dong-Kee Lee, Jianming Xu, Adeboye O. Osunkoya, Jin-Tang Dong. Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration. Nat Commun 11, 997, doi:10.1038/s41467-020-14737-8 (2020).
Yixiang Li, Baotong Zhang#, Lingwei Xiang, Siyuan Xia, Omer Kucuk, Xingming Deng, Lawrence H. Boise, Jin-Tang Dong#. TGF-beta causes Docetaxel resistance in Prostate Cancer via the induction of Bcl-2 by acetylated KLF5 and Protein Stabilization. Theranostics 10, 7656-7670, doi:10.7150/thno.44567 (2020).
Yuancheng Li, Hui Wu, Bing Ji, Weiping Qian, Siyuan Xia, Liya Wang, Yaolin Xu, Jing Chen, Lily Yang, Hui Mao. Targeted Imaging of CD206 Expressing Tumor-Associated M2-like Macrophages Using Mannose-Conjugated Antibiofouling Magnetic Iron Oxide Nanoparticles. ACS Applied Bio Materials 3, 4335-4347, doi:10.1021/acsabm.0c00368 (2020).
Xue Gao*, Liang Zhao*, Shuangping Liu*, Yuancheng Li, Siyuan Xia, Dong Chen, Mei Wang, Shaoxiong Wu, Qing Dai, Hieu Vu, Lauren Zacharias, Ralph DeBerardinis, Esther Lim, Christian Metallo, Titus J. Boggon, Sagar Lonial, Ruiting Lin, Hui Mao, Yaozhu Pan, Changliang Shan, Jing Chen. gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell 76, 857- 871 e859, doi:10.1016/j.molcel.2019.09.007 (2019).
Ran Tao*, Baotong Zhang*, Yixiang Li, Jamie L. King, Ruoyu Tian, Siyuan Xia, Cara Rae Schiavon, Jin-Tang Dong. HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation. Biochem Biophys Res Commun 500, 777-782, doi:10.1016/j.bbrc.2018.04.153 (2018).
Ruiting Lin, Siyuan Xia, Changliang Shan, Dong Chen, Yijie Liu, Xue Gao, Mei Wang, Hee-Bum Kang, Yaozhu Pan, Shuangping Liu, Young Rock Chung, Omar Abdel-Wahab, Taha Merghoub, Michael Rossi, Ragini R. Kudchadkar, David H. Lawson, Fadlo R. Khuri, Sagar Lonial, Jing Chen. The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells. Mol Cell 69, 923-937, doi:10.1016/j.molcel.2018.02.010 (2018).
Liang Zhao, Jun Fan, Siyuan Xia, Yaozhu Pan, Shuangping Liu, Guoqing Qian, Zhiyu Qian, Hee-Bum Kang, Jack L. Arbiser, Brian P. Pollack, Ragini R. Kudchadkar, David H. Lawson, Michael Rossi, Omar Abdel-Wahab, Taha Merghoub, Hanna J. Khoury, Fadlo R. Khuri, Lawrence H. Boise, Sagar Lonial, Fangping Chen#, Jing Chen#, Ruiting Lin. HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers. J Biol Chem 292, 10142-10152, doi:10.1074/jbc.M117.788778 (2017).
Shannon Elf*, Ruiting Lin*, Siyuan Xia, Yaozhu Pan, Changliang Shan, Shaoxiong Wu, Sagar Lonial, Manila Gaddh, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Titus J. Boggon, Jun Fan, Jing Chen. Targeting 6- phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene 36, 254-262, doi:10.1038/onc.2016.196 (2017).
Qian Zhang, Jian Mao, Xiaoxi Zhang, Haifeng Fu, Siyuan Xia, Zhinan Yin, Lin Liu. Role of Jnk1 in development of neural precursors revealed by iPSC modeling. Oncotarget 7, 60919-60928, doi:10.18632/oncotarget.11377 (2016).
Jun Fan*#, Ruiting Lin*, Siyuan Xia, Dong Chen, Shannon E. Elf, Shuangping Liu, Yaozhu Pan, Haidong Xu, Zhiyu Qian, Mei Wang, Changliang Shan, Lu Zhou, Qun-Ying Lei, Yuancheng Li, Hui Mao, Benjamin H. Lee, Jessica Sudderth, Ralph J. DeBerardinis, Guojing Zhang, Taofeek Owonikoko, Manila Gaddh, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Sumin Kang, Paul W. Doetsch, Sagar Lonial, Titus J. Boggon, Walter J. Curran, Jing Chen#. Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth. Mol Cell 64, 859-874, doi:10.1016/j.molcel.2016.10.014 (2016).
Xin Li, Baotong Zhang, Qiao Wu, Xinpei Ci, Ranran Zhao, Zhiqian Zhang, Siyuan Xia, Dan Su, Jie Chen, Gui Ma, Liya Fu, Jin-Tang Dong. Interruption of KLF5 acetylation converts its funciton from tumor suppressor to tumor promoter in prostate cancer cells. Int J Cancer 136, 536-546, doi:10.1002/ijc.29028 (2015).
Song Zhang, Ruifang Liang, Wei Luo, Chang Liu, Xiaoli Wu, Yanan Gao, Jianlei Hao, Guangchao Cao, Xi Chen, Jun Wei, Siyuan Xia, Zheng Li, Ti Wen, Yunyun Wu, Xinglong Zhou, Puyue Wang, Liqing Zhao, Zhenzhou Wu, Sidong Xiong, Xiaoming Gao, Xiang Gao, Yongyan Chen, Qing Ge, Zhigang Tian, Zhinan Yin. High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-gamma dysregulation of CD4+ T cells. Hepatology 57, 1620- 1631, doi:10.1002/hep.26166 (2013).
Baotong Zhang, Zhiqian Zhang, Siyuan Xia, Changsheng Xing, Xinpei Ci, Xin Li, Ranran Zhao, Sha Tian, Gui Ma, Zhengmao Zhu, Liya Fu, Jin-Tang Dong. KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells. Mol Cell Biol 33, 4919-4935, doi:10.1128/MCB.00787-13 (2013).
Xiaoli Wu*, Ji-Yuan Zhang*, Ang Huang, Yuan-Yuan Li, Song Zhang, Jun Wei, Siyuan Xia, Yajuan Wan, Weiwei Chen, Zheng Zhang, Yangguang Li, Ti Wen, Yan Chen, Yoshimasa Tanaka, Youjia Cao, Puyue Wang, Liqing Zhao, Zhenzhou Wu, Fu-Sheng Wang, Zhinan Yin. Decreased V delta 2 gamma delta T cells associated with liver damage by regulation of Th17 response in patients with chronic hepatitis B. J Infect Dis 208, 1294-1304, doi:10.1093/infdis/jit312 (2013).
Yangguang Li, Ti Wen, Minzhi Zhu, Lixin Li, Jun Wei, Xiaoli Wu, Mingzhou Guo, Shuangping Liu, Huiyuan Zhao, Siyuan Xia, Weili Huang, Puyue Wang, Zhenzhou Wu, Liqing Zhao, Wenqing Shui#, Zheng Li#, Zhinan Yin#. Glycoproteomic analysis of tissues from patients with colon cancer using lectin microarrays and nanoLC-MS/MS. Mol Biosyst 9, 1877-1887, doi:10.1039/c3mb00013c (2013).
Jianlei Hao, Siyuan Dong, Siyuan Xia, Weifeng He, Hao Jia, Song Zhang, Jun Wei, Rebecca L. O’Brien, Willi K. Born, Zhenzhou Wu, Puyue Wang, Jihong Han, Zhangyong Hong, Liqing Zhao, Zhinan Yin. Regulatory role of Vgamma1 gammadelta T cells in tumor immunity through IL-4 production. J Immunol 187, 4979-4986, doi:10.4049/jimmunol.1101389 (2011).
Jianlei Hao, Xiaoli Wu, Siyuan Xia, Zheng Li, Ti Wen, Na Zhao, Zhenzhou Wu, Puyue Wang, Liqing Zhao, Zhinan Yin. Current progress in gammadelta T-cell biology. Cell Mol Immunol 7, 409-413, doi:10.1038/cmi.2010.50 (2010).