Faculty
SELF-INTRODUCTION：
HUANG Yuesheng, Chair Professor，School of Medicine，has successively worked in the Burn Institute of the Third Military Medical University and the State Key Laboratory of Trauma, Burn and Combined Injuries since 1989 to 2022, and engaged in clinical treatment and translational research of burns and wound repair. In recent years, he has engaged in research of microenvironment and wound repair, new technologies and materials for microenvironment construction to improve wound in situ repair and regeneration. He has edited 10 monographs, and published more than 350 papers in international and domestic journals, including more than 20 national expert consensus and clinical guidelines.
He Won 4 second prizes of National Science and Technology Progress Award. Treatment techniques for early damage of severe burns was selected as an appropriate health technology promotion projects by the State Ministry of Health. He has elected as the chairman of Chinese Burn Association, chief editor of Chinese Journal of Burns, senior editorial board member of Burns, president of Burn & Trauma Branch of Chinese Geriatric Society, Chairman of Burn and Trauma Wound Repair Materials Branch of Chinese Biomaterials Society.
EDUCATION:
1978.09-1983.07 Bachelor of Medicine, Third Military Medical University
1983.08-1986.07 Master of Medicine, Third Military Medical University
1986.08-1989.11 Doctor of Medicine, Third Military Medical University
WOKRING EXPERIENCE:
1989.12-1997.04 Attending Surgeon, lecturer, associate professor, Professor of Surgery, Doctoral supervisor，associate director, Third Military Medical University
1997.05-1999.06 Postdoctoral Fellow, University of Texas Medical Branch, Galveston
1999.07-1999.11 Associate director, Professor of Surgery, Doctoral supervisor，Third Military Medical University
1999.12-2010.08 Director, Professor of Surgery, Doctoral supervisor, Institute of Burn Research, Third Military Medical University
2003.03-2005.05 Associate director, Professor of Surgery,State Key Laboratory of Trauma, Burn and Combined Injuries, Third Military Medical University
2005.06-2017.07 Director, Professor of Surgery, State Key Laboratory of Trauma, Burn and Combined Injuries, Third Military Medical University
2006.06-2010.08 President of Southwest Burn Hospital, Third Military Medical University
2010.08-2022.05 Honorary director, Institute of Burn Research，Third Military Medical University
2017.07-2022.05 Consultant，the State Key Laboratory of Trauma, Burn and Combined Injuries
2022.05- Chair Professor, Southern University of Science and Technology School of Medicine
2022.05- Director, Professor of Surgery, Department of Wound Repair, Southern University of Science and Technology Hospital
HONORS AND AWARDS:
National science fund for distinguished young scholars（2001, NSFC）
National level candidates of the new centuary national hundred,thousand and ten thousand talent project（2004, Ministry of Personnel of the People’s Republic of China）
Winner of Chinese doctor award（2009, Chinese Medical Doctor Association）
National outstanding scientific and technological workers（2012, Chinese Society for Science and Technology）
Lifetime achievement award in burn medicine（2017,Chinese Burn Association）
RESEARCH:
Microenvironment and wound repair.
New technologies and materials for microenvironment construction to improve wound in situ repair and regeneration.
Clinical techniques of wound repair.
RECENT SELECTED PAPERS：
1 Yan Shi,Shang Wang, Ronghua Yang, Zhenmin Wang, Weiwei Zhang, Hongwei Liu#, and Yuesheng Huang#. ROS Promote Hypoxia-Induced Keratinocyte Epithelial-Mesenchymal Transition by Inducing SOX2 Expression and Subsequent Activation of Wnt/-Catenin. Oxidative Medicine and Cellular Longevity, 2022, Article ID 1084006.
2 Yan-hai Feng, Ling-fei Li, Qiong Zhang, Jun-hui Zhang, Yao Huang, Yan-ling Lv, Jie-Zhi Jia, Dongxia Zhang, Jiong-Yu Hu# and Yue-Sheng Huang#. Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related Pyroptosis. Cell Death Discovery, 2021, 7:213.
3 Yao Huang, Yanhai Feng, Lin Cui, Lei Yang, Qiong Zhang, Junhui Zhang,Xupin Jiang, Xingyue Zhang, Yanling Lv, Jie-Zhi Jia, Dong-Xia Zhang#，Yue-Sheng Huang#. Autophagy-Related LC3 Accumulation nteracted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes. Front. Cell Dev. Biol. , 2021, 9: 679637.
4 Wei Jinyu, Lin Jiezhi, Zhang Junhui, Tang Di, Xiang Fei, Cui Lin, Zhang Qiong, Yuan Hongping, Song Huapei, Lv Yanling, Jia Jiezhi, Zhang Dongxia #, Huang Yuesheng#, TRPV1 Activation Mitigates Hypoxic Injury in Mouse Cardiomyocytes by Inducing Autophagy Through the AMPK Signaling Pathway. Am J Physiol Cell Physiol. 2020; 318(5):C1018-C1029.
5 Yi Liang, Hao Tian, Jie Liu , YanLing Lv, Yuan Wang, JiaPing Zhang#, YueSheng Huang#. Application of stable continuous external electric field promotes wound healing in pig wound model. Bioelectrochemistry, 2020, 135: 107578.
6 Xiaodong Lan, Zhiyong Huang, Ziming Tan, Zhenjia Huang, Dehuai Wang#，Yuesheng Huang#. Nebulized heparin for inhalation injury in burn patients: a systematic review and meta-analysis. Burns & Trauma, 2020, 8: tkaa015
7 Zhang X, Li L, Zhang Q, Wei Q, Lin J, Jia J, Zhang J, Yan T, Lv Y, Jiang X, Zhang P, Song H, Zhang D#，Huang Y# . CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia Conditions. Front. Cell Dev. Biol. , 2020, 8: 191.
8 Lin Cui, Li-Ping Zhao, Jing-Ying Ye, Lei Yang, Yao Huang, Xu-Pin Jiang, Qiong Zhang, Jie-Zhi Jia, Dong-Xia Zhang#, Yuesheng Huang#. The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes. Front. Cell Dev. Biol., 2020, 8: 31.
9 Xupin Jiang, Miao Teng, Ran Ji, Dongxia Zhang, Ze Zhang, Yanling Lv, Qiong Zhang, Jiaping Zhang#, Yuesheng Huang#. CD9 regulates keratinocyte differentiation and motility by recruiting Ecadherinto the plasma membrane and activating the PI3K/Akt pathway. BBA - Molecular Cell Research 2020; 1867 :118574
10 Junhui Zhang, Can Zhang, Xupin Jiang, Lingfei Li, Dongxia Zhang, Di Tang, Tiantian Yan, Qiong Zhang,Hongping Yuan, Jiezhi Jia, Jiongyu Hu, Jiaping Zhang，Yuesheng Huang*. Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration. Cell Death and Disease 2019；10:234.
11 Tiantian Yan, Xupin Jiang, Guoan Lin, Di Tang, Junhui Zhang, Xiaowei Guo, Dongxia Zhang, Qiong Zhang, Jiezhi Jia, Yuesheng Huang*. Autophagy is required for the directed motility of keratinocyte driven by electric fields. FASEB J . 2019; 33(3): 3922-3935.
12 Lei Yang, Liping Zhao, Lin Cui, Yao Huang, Jingying Ye, Qiong Zhang, Xupin Jiang, Dongxia Zhang#, Yuesheng Huang#. Decreased α-tubulin acetylation induced by an acidic environment impairs autophagosome formation and leads to rat cardiomyocyte injury. J Mol Cell Cardiol. 2019; 127: 143-153.
13 Lingfei Li, Xingyue Zhang, Qiong Zhang, Jiezhi Jia,Junhui Zhang,Dongxia Zhang, Huapei Song, Bing Chen , Jiongyu Hu# , Yuesheng Huang#. Myocardial Adipose Triglyceride Lipase Overexpression Protects against Burn-Induced Cardiac Lipid Accumulation and Injury.Oxidative Medicine and Cellular Longevity 2019；Article ID 6428924.
14 Junhui Zhang, Lingfei Li, Qiong Zhang, Xu Yang, Can Zhang, Xingyue Zhang, Dongxia Zhang, Yanling Lv, Huapei Song, Bing Chen, Yao Liu, Jiongyu Hu#, Yuesheng Huang#. Phosphorylation of Microtubule-Associated Protein 4 Promotes Hypoxic Endothelial Cell Migration and Proliferation. Front. Pharmacol. 2019;10:368.
15 Li L, Zhang J, Zhang Q, Zhang D, Xiang F, Jia J, Wei P, Zhang J, Hu J#， Huang Y#. High Glucose Suppresses Keratinocyte Migration Through the Inhibition of p38 MAPK/Autophagy Pathway. Front. Physiol. 2019;10:24.
16 Lingfei Li, Junhui Zhang, Qiong Zhang, Yuesheng Huang#. Jiongyu Hu#. Cardiac proteomics reveals the potential mechanism of microtubule associated protein 4 phosphorylation-induced mitochondrial dysfunction. Burns & Trauma 2019; 7:8.
17 Fei Xiang, Si-yuan Ma, Yan-ling Lv, Dong-xia Zhang, Hua-pei Song，Yue-sheng Huang*.Tumor necrosis factor receptor-associated protein 1 regulates hypoxia-induced apoptosis through a mitochondria-dependent pathway mediated by cytochrome c oxidase subunit II. Burns& Trauma 2019; 7:16.
18 Junhui Zhang, Lingfei Li, Qiong Zhang, Wensheng Wang, Dongxia Zhang, Jiezhi Jia, Yanling Lv, Hongping Yuan, Huapei Song, Fei Xiang, Jiongyu Hu#, Yuesheng Huang#. Microtubule-associated protein 4 phosphorylation regulates epidermal keratinocyte migration and proliferation. Int J Biol Sci.，2019; 15(9): 1962-1976.
19 Lingfei Li, Qiong Zhang, Xingyue Zhang, Junhui Zhang, Xuefeng Wang, Jun Ren, Jiezhi Jia, Dongxia Zhang, Xupin Jiang, Jiaping Zhang, Hao Mei, Bing Chen, Jiongyu Hu#, Yuesheng Huang#. Microtubule associated protein 4 phosphorylation leads to pathological cardiac remodeling in mice. EBioMedicine 2018；37:221-235.
20 Hao Tian, Liangxi Wang, WeiguoXie, Chuanan Shen, Guanghua Guo, Jiaqi Liu, Chunmao Han, Licheng Ren, Yi Liang, Yong Tang, Yuan Wang, Weifang Yin, Jiaping Zhang# , Yuesheng Huang#. Epidemiologic and clinical characteristics of severe burn patients: results of a retrospective multicenter study in China, 2011-2015. Burns & Trauma 2018; 6(2): 140-150.
21 Junhui Zhang，Dongxia Zhang，Tiantan Yan，Xupin Jiang，Can Zhang，?Liping Zhao，Lingfei Li，Di Tang，Qiong Zhang，Jiezhi Jia，Jiaping Zhang，Yuesheng Huang #. BNIP3 promotes the motlity and migraton of keratnocyte under hypoxia. Experimental Dermatology 2017; 26: 416–422.
22 Di Tang, Tiantian Yan, Junhui Zhang, Xupin Jiang, Dongxia Zhang, Yuesheng Huang*. Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration. Scientific Reports 2017; 7:43926.
23 Tiantian Yan, Junhui Zhang, Di Tang, Xingyue Zhang, Xupin Jiang, Liping Zhao, Qiong Zhang, Dongxia Zhang, Yuesheng Huang*. Hypoxia Regulates mTORC1-Mediated Keratinocyte Motility and Migration via the AMPK Pathway. PLoS ONE， 2017; 12(1): e0169155.
24 Tiantian Yan, Xupin Jiang, Xiaowei Guo, Wen Chen, Di Tang, Junhui Zhang, Xingyue Zhang, Dongxia Zhang, Qiong Zhang, Jiezhi Jia, Yuesheng Huang*. Electric field-induced suppression of PTEN drives epithelial-to -mesenchymal transition via mTORC1 activation. J Dermatol Sci， 2017; 85(2): 96–105.
25 Chen Wen，Jiang Youzhao， Han Jian， Hu Jiongyu，He Ting， Yan Tiantian，Huang Na，Zhang Qiong，Mei Hao，Liao Yong，Huang Yuesheng#，Chen, Bing#. Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage. FEBS Journal, 2017; 284(7): 1070-1081.
26 Liping Zhao, Lin Cui, Xupin Jiang, Junhui Zhang, Minghua Zhu, Jiezhi Jia, Qiong Zhang, iaping Zhang, Dongxia Zhang#, Yuesheng Huang#. Extracellular pH regulates autophagy via the AMPK–ULK1 pathway in rat cardiomyocytes. FEBS Letters，2016；590 ：3202–3212 （IF 4.124）
27 Fei Xiang, Si-Yuan Ma, Dong-Xia Zhang, Qiong Zhang, Yue-Sheng Huang*. Tumor necrosis factor receptor-associated protein 1 improveshypoxia-impaired energy production in cardiomyocytes through increasing activity of cytochrome c oxidase subunit II. Int J Biochem Cell Biol , 2016；79：239–248.
28 Zhang Dong-Xia, Zhang Jia-Ping, Hu Jiong-Yu, Huang Yue-Sheng*. The potential regulatory roles of NAD+ and its metabolism in autophagy. Metabolism: Clinical and Experimental. 2016，65: 454–462.
29 Xiaodong Lan, Lingfei Li, Jiongyu Hu, Qiong Zhang, Yongming Dang#, Yuesheng Huang#. A Quantitative Method for Microtubule Analysis in Fluorescence Images. Microsc. Microanal，2015， 21（12）：1582–1590.
30 Xiaowei Guo, Xupin Jiang, Xi Ren, Huanbo Sun, Dongxia Zhang, Qiong Zhang, Jiaping Zhang# ,Yuesheng Huang#. The Galvanotactic Migration of Keratinocytes is Enhanced by Hypoxic Preconditioning. Scientific Reports 2015; 5:10289.
31 Yongming Dang, Xiaodong Lan, Qiong Zhang, Lingfei Li, Yuesheng Huang*. Analysis of Grayscale Characteristics in Images of Labeled Microtubules from Cultured Cardiac Myocytes. Microsc. Microanal.2015, 21, 334–342.
32 Xupin Jiang, Dongxia Zhang, Hengshu Zhang, Yuesheng Huang, Miao Teng. Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1a in hypoxic cardiomyocytes. Sci Rep, 2015; 5 : 9193.
33 Lingfei Li, Jiongyu Hu, Ting He, Qiong Zhang, Xu Yang, Xiaodong Lan, Dongxia Zhang, Hao Mei, Bing Chen#, Yuesheng Huang#. P38/MAPK contributes to endothelial barrier dysfunction via MAP4 phosphorylation-dependent microtubule disassembly in inflammation-induced acute lung injury. Sci Rep 2015; 5 : 8895.
34 Ting He, Jiongyu Hu, Guangning Yan, Lingfei Li, Dongxia Zhang, Qiong Zhang, Bing Chen#, Yuesheng Huang#. Pigment epithelium-derived factor regulates microvascular permeability through adipose triglyceride lipase in sepsis.Clin Sci 2015; 129: 49–61.
35 Xupin Jiang, Xiaowei Guo, Xue Xu, Miao Teng, Chong Huang, Dongxia Zhang, Qiong Zhang, Jiaping Zhang#, Yuesheng Huang#. Hypoxia regulates CD9-mediated keratinocyte migration xia the P38/MAPK pathway. Sci. Rep.,2014; 4, 6304.
36 J Hu , Z Chu , J Han , Q Zhang , D Zhang , Y Dang , J Ren , HC Chan , J Zhang#, Y Huang#. Phosphorylation-dependent mitochondrial translocation ofMAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes. Cell Death Dis, 2014, 5, e1424.
37 Xue Xu , Qiong Zhang , Jiong-yu Hu, Dong-xia Zhang, Xu-pin Jiang , jie-zhi Jia , Jing-ci Zhu#, Yue-sheng Huang#. Phosphorylation of DYNLT1 at Serine 82 Regulates MTs Stability and Mitochondrial Permeabilization in Hypoxia. Mol. Cells, 2013, 36（10）：322-332.
38 Dong-xia Zhang Hong Yan, Jiong-yu Hu, Jia-ping Zhang, Miao Teng, Da-li Tong, Fei Xiang, Qiong Zhang, Ya-dong Fang, Guang-ping Liang, Yue-sheng Huang*. Identification of mitochondria translation elongation factor Tu as a contributor to oxidative damage of postburn myocardium. J Proteomics, 2012; 77（9）：469-479.
39 Jiaping Zhang，Jianda Dong，Hua Gu，Sidney Yu，Xiaohu Zhang，Yulin Gou，Wenming Xu，Andrew Burd，Lin Huang，Kenji Miyado，Yuesheng Huang#, Hsiao Chang Chan#. CD9 Is Critical for Cutaneous Wound Healing through JNK Signaling. Journal of Investigative Dermatology 2012；132：226–236.
40 Miao Teng, XiaoHui Zhao, YueSheng Huang*. Regenerating cardiac cells: insights from the bench and the clinic. Cell Tissue Res 2012；350: 189–197.
41 Hong Yan, Dong-Xia Zhang, Xiaohua Shi, Qiong Zhang, Yue-sheng Huang*. Activation of the Prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes. J Cell Mol Med. 2012；16（9）：2049-2059
42 Xiao Rong, Ze-Yuan Lei, MD, Yong-Ming Dang, Huang Yue-sheng*. Prompt Myocardial Damage Initiates Hepatic, Renal and Intestinal Injuries Early Following Severe Burns in Rats. J Trauma, 2011, 71: 663–672.
43 Jiong-Yu Hu, Zhi-Gang Chu, Jian Han, Hong Yan, Yong-ming Dang, Qiong Zhang, Yue-Sheng Huang*. p38/MAPK Pathway Regulates Microtubule Polymerization Through Phosphorylation of MAP4 and Op18 in hypoxic cells. Cell. Mol. Life Sci., 2010, 67(2):321–333.
44 Fei Xiang, Yue-Sheng Huang*, Xiao-Hua Shi and Qiong Zhang. Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening. FEBS J, 2010, 277 (8) ：1929–1938.
45 Miao Teng, Yong-Ming Dang, Jia-ping Zhang, Qiong Zhang, Ya-dong Fang, Jun Ren, Yue-sheng Huang*. Microtubular stability affects cardiomyocyte glycolysis by HIF-1α expression and endonuclear aggregation during early stages of hypoxia. Am J Physiol Heart Circ Physiol, 2010, 298（6）：H1919-H1931.