Faculty
SELF-INTRODUCTION：
CHEN Hao, PhD, Assistant Professor, received his BS degree in Biology from Wuhan University in 2008 and PhD degree in Molecular Biology & Disease Proteomics from the Fudan University in 2013. Dr. Chen completed his postdoctoral training in Boston Children's Hospital at the Harvard Medical School in 2019. He has published 16 research articles(average Impact Factor: 17.06) on top journals of the epigenetic field, including Nature, Cell Research, PNAS and JBC. His research interests are investigation of epigenetic mechanisms in human disease and identification of novel epigenetic modifications and modulators.
EDUCATION:
2013 PhD Molecular Biology & Disease Proteomics Fudan University
2008 B.S. National Base of Biology Wuhan University
WOKRING EXPERIENCE:
02/2015-12/2019 Research Fellow Boston Children’s Hospital, HMS
07/2013-01/2015 Research Assistant IBS, Fudan University
HONORS AND AWARDS:
2013 Magna cum Laude Fudan University
2013 Excellent Presentation Translational Cancer Research Forum
2012 National Scholarship Chinese Ministry of Education
2012 Excellent Presentation Shanghai Life-science Forum
Research:
1.Epigenetic mechanisms in human disease;
2.Novel epigenetic modifications and modulators.
PUBLICATIONS：
First/Co-first author：
1.Chen, H., Shi, Z., Guo, J., Chang, K., Chen, Q., Yao, C., Haigis,M., Shi, Y. (2020). The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for proper mitochondrial function. Journal of Biological Chemistry. RA119. 012127
2.Chen, H.#, Gu, L.#, Orellana, E., Wang, Y., Guo, J., Liu, Q., Gregory, R., Xing, Y., Shi, Y. (2020). METTL4 is an m6Am methyltransferase that regulates RNA splicing. Cell Research. doi:1038 /s41422-019-0270-4 (#co-first author) (F1000 recommended)
3.Chen, H., Yu, D., Fang, R., Rabidou, K., Wu, D., Hu, D., . . Shi, Y. G. (2019). TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer. Cell Research. 29, 248–250.
4.Wu, D.#, Hu, D.#, Chen, H.#, Shi, G.#, Fetahu, I. S., Wu, F., . . . Shi, Y. G. (2018). Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 559(7715), 637-641. (#co-first author) (Highlighted by Nature Reviews Cancer, Nature Reviews Molecular Cell Biology, Science, Trends in Cancer, Cancer Discovery and Cell Metabolism)
5.Chen, H., Ma, H., Inuzuka, H., Diao, J., Lan, F., Shi, Y. G., . . . Shi, Y. (2013). DNA damage regulates UHRF1 stability via the SCFβ-TrCP E3 ligase. Molecular and Cellular Biology. 33: 1139-1148. (Spotlight in the issue)
6.Ma, H.#, Chen, H.#, Guo, X.#, Wang, Z., Sowa, M. E., Zheng, L., . . . Shi, Y. (2012). M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. PNAS (Proceedings of the National Academy of Sciences).109: 4828-4833. (#co-first author)
7.Gu, L.#, Wang, L.#, Chen, H.#, Hong, J.#, Shen, Z., Dhall, A., Lao, T., . . . Wu, H., Shi, Y. (2020). CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila. bioRxiv. doi: https://doi.org/10.1101/2020.01.09.890764 (#co-first author)
8.Chen, H.#, Liu, Q.#, Yu, D., Natchiar, K., Zhou, C., Hsu, C.-h., Hsu, P.-H., Zhang, X., Klaholz, B., Gregory, R. and Shi, Y. (2020) METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes. bioRxiv. doi: https://doi.org/10.1101/2020.04.27.064162 (#co-first author)
Co-author：
9.Sendinc, E., Valle-Garcia, D., Dhall, A., Chen, H., Henriques, T., Navarrete-Perea, J., Sheng, W., Gygi, S., Adelman, K., Shi, Y.(2019). PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Molecular Cell.
10.Lee, Y., Chen, M., Lee, J., Zhang, J., Lin, S., Fu, T., Chen, H., Ishikawa, T., Chiang, S., Katon, J., .... Wei W., Pandolfi P.(2019). Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 364,6441.
11.Ma, H., Wang, X., Cai, J., Dai, Q., Natchiar, S. K., Lv, R., . . Chen, H., . . He,C. (2019). N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nature Chemical Biology. 15(1), 88.
12.Sheng, W., LaFleur, M. W., Nguyen, T. H., Chen, S., Chakravarthy, A., Conway, J. R., . . Chen, H.,. . Shi, Y. (2018). LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Cell.174(3), 549-563 e519.
13.Xiang, Y., Laurent, B., Hsu, C.-H., Nachtergaele, S., Lu, Z., Sheng, W.,Chen, H., . . . Shi, Y.(2017). RNA m 6A methylation regulates the ultraviolet-induced DNA damage response. Nature. 543(7646), 573.
14.Cai, J. B., Shi, G. M., Dong, Z. R., Ke, A. W., Ma, H. H., Gao, Q., Chen, H., . . Fan, J. (2015). Ubiquitin‐specific protease 7 accelerates p14ARF degradation by deubiquitinating thyroid hormone receptor‐interacting protein 12 and promotes hepatocellular carcinoma progression. Hepatology. 61(5), 1603-1614.
15.Guo, R., Zheng, L., Park, J. W., Lv, R.,Chen, H., Jiao, F., . Shi, Y. (2014). BS69/ZMYND11 reads and connects histone H3.3 lysine36 trimethylation-decorated chromatin to regulated pre-mRNA processing. Molecular Cell. 56(2), 298-310.
16.Rajakumara, E., Wang, Z., Ma, H., Hu, L., Chen, H., Lin, Y., Guo, R., Wu, F., Li, H., Lan, F., et al. (2011). PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression. Molecular Cell. 43, 275-284.