師資
個人簡介
南方科技大學(xué)講席教授、醫(yī)學(xué)院副院長，烏克蘭工程院外籍院士，國際華人骨研學(xué)會現(xiàn)任主席，廣東省細胞微環(huán)境與疾病研究重點實驗室主任, 美國骨礦研究學(xué)會(ASBMR)會士, 連續(xù)榮登愛思唯爾中國高被引學(xué)者和全球前2%頂尖科學(xué)家榜單。研究骨骼發(fā)育和骨骼疾病 （骨質(zhì)疏松、骨關(guān)節(jié)炎等）的相關(guān)分子基礎(chǔ)。北京大學(xué)醫(yī)學(xué)部博士；美國密歇根大學(xué)博士后；美國匹茨堡大學(xué)醫(yī)學(xué)院助理教授、副教授；美國拉什大學(xué)教授、冠名講席教授、生物化學(xué)系的研究主任；歷任南方科技大學(xué)生物系系主任、致誠書院院長。主持國自然重大、重點等項目。發(fā)表SCI文章188篇, 引用21000余次，總影響因子約2000, H指數(shù)72。實驗室成果在國際骨科研究大會獲獎10余次。擔任JOT副主編, 擔任JBMR及 JBC等國際學(xué)術(shù)刊物編委，擔任70個國際雜志的審稿人。北京大學(xué)醫(yī)學(xué)部（原北京醫(yī)科大學(xué)）100周年校慶，優(yōu)秀校友。
研究領(lǐng)域
（1）研究調(diào)節(jié)骨骼發(fā)育及穩(wěn)態(tài)的分子機制；
（2）研究骨質(zhì)疏松癥，骨性關(guān)節(jié)炎及脊柱退行性變等骨骼疾病的分子基礎(chǔ)；
（3）研究骨機械應(yīng)力信號傳導(dǎo)機制；
（4）代謝性疾病的發(fā)病機制研究。
教育背景
1991-1994：北京大學(xué)醫(yī)學(xué)部生物化學(xué)和分子生物學(xué)系，博士學(xué)位
1985-1988：北京大學(xué)醫(yī)學(xué)部生物化學(xué)和分子生物學(xué)系，碩士學(xué)位
1979-1984：南昌大學(xué)醫(yī)學(xué)院醫(yī)療系，醫(yī)療專業(yè)，醫(yī)學(xué)學(xué)士學(xué)位
工作經(jīng)歷
2020- 南方科技大學(xué)教授, 醫(yī)學(xué)院副院長
2019-2020 南方科技大學(xué)致誠書院院長
2017- 南方科技大學(xué)實驗動物中心主任
2015-2018 南方科技大學(xué)生物系系主任
2013-2019 南方科技大學(xué)生物系教授
2012-2017 美國拉什大學(xué)醫(yī)學(xué)中心副教授，正教授、講席教授(Falk Chair Professor)、生物化學(xué)系科研主任
2005-2011 美國匹茲堡大學(xué)醫(yī)學(xué)院助理教授、終身副教授
1994-2005 美國密歇根大學(xué)醫(yī)學(xué)院/牙學(xué)院博士后、講師、研究助理教授
1988-1991 北京大學(xué)醫(yī)學(xué)部， 講師
獲獎情況及榮譽
2023 國際華人骨研學(xué)會主席 (International Chinese Musculoskeletal Research Society (ICMRS), president); https://icmrs.net/leadership
2022 南方科技大學(xué)優(yōu)秀研究生導(dǎo)師獎
2022 烏克蘭工程院外籍院士
2021, 2022, 2023, 2024 全球前2%頂尖科學(xué)家 (World’s Top 2% Scientists by Stanford University)
2021, 2022, 2023 愛思唯爾 (Elsevier)中國高被引學(xué)者 （生物學(xué)）(Most Cited Chinese Researchers, Biology)
2020 南方科技大學(xué)年度教授獎
2019 國際骨科研究聯(lián)合學(xué)會 (ICORS)，會士
2019 美國骨與礦研究學(xué)會 (ASBMR), 會士
2012 北京大學(xué)醫(yī)學(xué)部(原北京醫(yī)科大學(xué)) 100周年校慶，優(yōu)秀校友
雜志編委、副主編
2023- Journal of Orthopaedic Translation (JOT), associate editor
2009-2015 Journal of Bone and Mineral Research (JBMR), editorial board member
2013-2022 Journal of Biological Chemistry (JBC), editorial board member
代表文章
From total 200 publications
1. Walke W, Xiao G, and Goldman D. A dual function activity-dependent, muscle-specific enhancer from rat nicotinic acetylcholine receptor d-subunit gene. J Neurobiol. 1996; 31(3): 359-369.
2. Walke W, Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor d-subunit promoter. J Neurosci. 1996; 16(11): 3641-3651.
3. Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11:1103-1113.
4. Xiao G, Wang D, Benson MD, Karsenty G, and Franceschi RT. Role of the a2 integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem. 1998; 273, 32988-32994.
5. Frendo JL, Xiao G, Fuches S, Franceschi RT, Karsentry G, and Ducy P. Functional hierarchy between two OSE2 elements in the control of osteocalcin expression in vivo. J Biol Chem. 1998; 273, 30509-30516.
6. Wang D, Christensen, K, Chawla, K, Xiao G, Krebsbach P. and Franceschi, RT. Isolation and characterization of MC3T3-E1 murine preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res. 1999; 14:893-903.
7. Benson MD, Aubin JE, Xiao G, Thomas PE, and Franceschi RT. Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Cbf/runt binding sites. J Bone Miner Res. 1999; 14:396-405.
8. Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1. J Biol Chem. 2000; 275, 4453-4459.
9. Benson MD, Bargeon JL, Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression. J Biol Chem. 2000; 275: 13907-13917.
10. Franceschi RT. Xiao G, Thomas PE, Jiang D, and Benson MD. Extracellular matrix regulation of osteoblast-specific gene expression: role of the a2b1 integrin and Osf2/Cbfa1. Chemistry and Biology of Mineralized Tissues: Connect Tissue Res. 2000;41 Suppl 1:249-254.
11. Ma PX, Zhang R, Xiao G, and Franceschi RT. Engineering new bone tissue in vitro on highly pore poly(-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res. 2001; 54:284-293.
12. Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277:36181-36187.
13. Zhao M, Xiao G, Berry J, Franceschi RT, Reddi A, and Somerman MJ. Bone Morphogenetic Protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002; 17:1441-1451.
14. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17:101-110.
15. Franceschi RT and Xiao G. Regulation of osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003; 88:446-454.
16. Franceschi RT. Xiao G, Jiang D, Gopalakrishnan R, Yang S and Reith E. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation: Connect Tissue Res. 2003;44 Suppl 1:109-16.
17. Chen C, Koh AJ, Datta NS, Zhang J, Even ET, Xiao G, Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem. 2004; 279, 29121-29129.
18. Jiang D, Franceschi RT, Boules H, and Xiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene:requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337.
19. Xiao G*, Jiang D, Ge C, Zhao Z, Yumei Lai, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, and Franceschi RT. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem. 2005; 280:30689-30696.
20. Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem. 2005; 280:30845-30855.
21. Zhao Z, Zhao M, Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. Mol Ther. 2005; 12(2):247-53.
22. Lu, Y, Cai Z, Galson DL, Xiao G, Liu, Y, George DE, Melhem MF, Yao Z, Zhang J. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate. 2006; 66(12): 1311-8.
23. Franceschi RT, Xiao G. Osteoblasts: Staying the course. Meeting report from the 29th Annual Meeting of the American Society for Bone and Mineral Research. BoneKEy-Osteovision 2006; 4 (12), 327-332.
24. Zhu J, Jia X, Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases. J Biol Chem.2007; 282(37): 26656-64.
25. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 2007; 1116:196-207.
26. Lu Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrP-induced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis. Int J Cancer. 2007; 121(4): 724-733.
27. Lu Y, Cai Z, Xiao G, Liu Y, Keller E, Yao Z, and Zhang J. CCR2 expression correlates with prostate cancer progression. J Cell Biochem. 2007; 101(3): 676-85.
28. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. Cancer Res. 2007; 67(8): 3646-53.
29. Ge C, Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007; 176(5): 709-818. PMCID: PMC2064027.
30. Feng, R, Anderson G, Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-kB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood. 2007; 109(3): 2130-2138.
31. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology. 2008; 149(4): 1960-8. PMCID: PMC2276723.
32. Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J, Xiao G. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells. J Cell Biochem. 2008 Feb 1;103(2):434-46. doi: 10.1002/jcb.21411.PMID: 17516572。
33. Chen D, Xiao G, Zhang M, Xing L, and Jonason JH. Post-translational regulation of Runx2 in bone cells. J Dent Res. 2008; 88(8): 693-703.
34. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs. 2009;189(1-4):144-152.
35. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. General transcription factor IIA-gamma increases?osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J Biol Chem. 2008; 283(9): 5542-53. PMCID: PMC2736298.
36. Zhang X, Yu S, Galson, DL, Luo M, Fan J, Zhang J, Guan Y, Xiao G. Activating?transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. J Cell Biochem. 2008; 105(3): 885-95. PMCID: PMC2704124.
37. Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson M, Fan J. Interacting neuro-endocrine, innate, and acquired immune pathways regulate neutrophil from bone marrow following hemorrhage shock. J Immnol. 2009;182(1):572-580. PMCID: PMC2610356.
38. Cai, Z, Chen Q, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q, Zhang J. Monocyte chemotactic protein-1 promotes lung cancer-induced bone resorptive lesion in vivo. Neoplasia. 2009;11(3):228-36. PMCID: PMC2647725.
39. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC2762317. (This paper was listed as the "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy. BoneKEy is published by the International Bone & Mineral Society).
40. Ge C, Xiao G (co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC2781667.
41. Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC2803625.
42. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD, Xiao G. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010 Aug 2;120(8):2755-66. PMCID: PMC2912190.
43. Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK, Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice. J Clin Invest. 2010 Nov 1;120(11):3901-11. PMCID: PMC2964981.
44. Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol. 2011 Mar;44(3):333-40. PMCID: PMC3095934.
45. Yang S, Xu H, Yu S, Cao H, Jie Fan, Ge C, Fransceschi RT, Dong HH, Xiao G. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem. 2011; 286(21):19149-58. PMCID: PMC3099728.
46. Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immnol. 2011; 187(9) :4809-17, PMCID: PMC3197874.
47. Danciu TH, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT. The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts. J Cell Biochem. 2011;113(1):70-9. PMCID: PMC3414260.
48. D'Souza S, Del Prete D, Jin S, Sun Q, Huston AJ, Kostov FE, Sammut B, Hong CS, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Grimes HL, Roodman GD, Galson DL. Gfi-1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease. Blood. 2011;118(26):6871-80. PMCID: PMC3245209.
49. Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8. PMCID: PMC3265850.
50. Xiang M, Yuan Y, Fan L, Li Y, Li A, Yin L, Scott MJ, Xiao G, Billiar TR, Wilson MA, Fan J. Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock. Shock. 2012 May;37(5):518-523. PMCID: PMC3328610.
51. Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Kc R, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul;113(7):2532-42. PMCID: PMC3349778.
52. Xiao G*, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C*. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC3375566.
53. Ellman MB, Kim JS, An HS, Chen D, Ranjan KC, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disc homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 1;505(2):283-90, PMCID: PMC3518428.
54. Yan D, Chen D, Xiao G, van Wijnen A, Im HJ. Bovine lactoferricin, an antimicrobial peptide, is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb;228(2):447-56, PMCID: PMC3463726.
55. Meng M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, Chen D. Chondrocyte BMP-2 Signaling Plays a Critical Role in Bone Fracture Healing. Gene. 512 (2013) 211–218. PMCID: PMC3531824.
56. Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, Chen D, Wang Q, Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis. Gene. 513 (2013) 101–110. PMCID: PMC3514579.
57. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-266. PMCID: PMC3596711.
58. Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction. J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC3646900.
59. Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Zabo G, Hoskin DW, Buechter DD, van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep;228(9):1884-96. PMCID: PMC3703102.
60. Ellman MB, Kim J, An HS, Chen D, Kc R, Li X, Xiao G, Yan D, Suh J, van Wijnen A, Wang J, Kim S, Im H. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 Jul 25;524(2):282-91. PMCID: PMC3679319.
61. Liu Z, Jiang Y, Li Y, Wang J, Fan L, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation. J Immunol. 2013 Jul 15;191(2):857-64. PMCID: PMC3702632.
62. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Chen D, Yao Z, Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013 Aug 21;9(8):830-41. PMCID: PMC3753447.
63. Xiao G*, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH*. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice. J Biol Chem. 2013 Aug 30;288(35):25350-61. PMCID: PMC3757199.
64. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res.2013;28: 1870–1884. PMID: 23649506. This is an EDITOR'S CHOICE paper of September 2013 JBMR issue and highlighted with a Commentary paper ( Schipani et al. J Bone Miner Res. 2013;28:1866-1869. DOI: 10.1002/jbmr.2045).
65. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC3798504.
66. Yan D, Kc R, Chen D, Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: 24036113.
67. Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, Chen D Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast differentiation. Arthritis Rheumatol. 2014 Jan;66(1):107-20. doi: 10.1002/art.38195. PMID: 244312822.
68. Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ. BMP-2 regulates chondrocyte differentiation through modulation of COX-2 and ATF4. Osteoarthritis Cartilage. 2014 Mar;22(3):481-9. PMID: 24418675.
69. Li S, Shu B, Zhang Y, Li J, Guo J, Wang Y, Ren F, Xiao G, Chang Z, Chen D. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. Arthritis Rheumatol. 2014 Jul;66(7):1854-63. doi: 10.1002/art.38521. PMID: 24578159.
70. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014 Aug;21(8):1229-39. PMID: 24769733. PMCID: PMC4085529.
71. Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem. 2014 Nov 7;289(45):31001-13. PMID: 2523719.
72. Wen Z, Fan L, Li Y, Zou Z, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Shi X, Fan J. Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation. J Immunol. 2014 Nov 1;193(9):4623-33. PMID: 25267975.
73. Niu NK, Wang ZL, Pan ST, Ding HQ, Au GHT, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther. 2015 Mar 12;9:1555-84. PMID: 25792811.
74. Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J, Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy. J Biol Chem. 2015 Mar 27;290(13):8081-94. doi: 10.1074/jbc.M114.603985. Epub 2015 Feb 3. PMID: 25648889.
75. Wu C, Jiao H, Lai Y, Zheng W, Chen K, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 7;6:7531. doi: 10.1038/ncomms8531. PMID: 26151572.
76. Kim JS, Ahmadinia K, Li X, Hamilton JL, Andrews S, Haralampus CA, Xiao G, Sohn HM, You JW, Seo YS, Stein GS, Van Wijnen AJ, Kim SG, Im HJ. Development of an experimental animal model for lower back pain by percutaneous injury-induced lumbar facet joint osteoarthritis. J Cell Physiol. 2015 Nov;230(11):2837-47. doi: 10.1002/jcp.25015. PMID: 25858171.
77. Qin TT, Xu GC, Qi JW, Yang GL, Zhang K, Liu HL, Xu LX, Xiang R, Xiao G, Cao H, Wei Y, Zhang QZ, Li LY. Tumor necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via upregulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol. 2015 Nov;237(3):307-18. doi: 10.1002/path.4577. Epub 2015 Aug 6. PMID: 26096340.
78. Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W, Pang Y, Wang Y, Mu X, Ni Y, Li Z, Xu H, Hao S, Wang X, Ma S, Wang QF, Xiao G, Yuan W, Liu B, Cheng T. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood. 2015 Nov 19;126(21):2383-91. doi: 10.1182/blood-2015-03-633354. Epub 2015 Sep 17. PMID: 26384355.
79. Kim JS, Ali MH, Wydra F, Li X, Hamilton JL, An HS, Cs-Szabo G, Andrews S, Moric M, Xiao G, Wang JH, Chen D, Cavanaugh JM, Im HJ. Characterization of degenerative human facet joints and facet joint capsular tissues. Osteoarthritis Cartilage. 2015 Dec;23(12):2242-51. PMID: 26117175, PMCID: PMC4663154.
80. Zhu K, Song P, Lai Y, Xiao G. Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts. Gene. 2016 Dec 5;594(1):125-130. doi: 10.1016/j.gene.2016.09.011. PMID: 27614241.
81. Z Li, M J Scott, E K Fan, Y Li, J Liu, G Xiao, S Li, T R Billiar, M A Wilson, Y Jiang and J Fan. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016 Sep 1;23(9):1428-47. doi: 10.1038/cdd.2016.21. Epub 2016 Mar 4.
82. Xu H, Cao H, Xiao G. Signaling via PINCH: functions, binding partners and implications in human diseases. Gene. 2016 Dec 5;594(1):10-15. doi: 10.1016/j.gene.2016.08.039. Review. PMID: 27590440.
83. Fu W, Hu W, Shi L, Mundra JJ, Xiao G, Dustin ML, Liu CJ. Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis. FASEB J. 2017 Apr;31(4):1354-1367. doi: 10.1096/fj.201601134R. Epub 2016 Dec 23. PMID: 28011648.
84. Xiao M, Wang Y, Tao C, Wang Z, Yang J, Chen Z, Zou Z, Li M, Liu A, Jia C, Huang B, Yan B, Lai P, Ding C, Cai D, Xiao G, Jiang Y, Bai X. Osteoblasts support megakaryopoiesis through production of interleukin 9. Blood. 2017;129(24):3196–3209. doi:10.1182/blood-2016-11-749838.
85. Zhang M, Yang H, Lu L, Wan X, Zhang J, Zhang H, Liu X, Huang X, Xiao G, Wang M. Matrix replenishing by BMSCs is beneficial for osteoarthritic temporomandiblar joint cartilage. Osteoarthritis Cartilage. 2017 Sep;25(9):1551-1562. doi: 10.1016/j.joca.2017.05.007. Epub 2017 May 19.
86. Zhang Y, Xu S, Li K, Tan K, Liang K, Wang J, Shen J, Zou W, Hu L, Cai D, Ding C, Li M, Xiao G, Liu B, Liu A, Bai X. mTORC1 inhibits NF-kB/NFATc1 signaling and prevents osteoclast precursor differentiation, in vitro and in mice. J Bone Miner Res. 2017 Sep;32(9):1829-1840. doi: 10.1002/jbmr.3172. Epub 2017 Jul 11. PMID: 28520214.
87. Sun Y, Guo C, Ma P, Lai Y, Yang F, Cai J, Sheng Y, Cheng Z, Tian R, Deng Y, Xiao G*, Wu C*. Kindlin-2 association with Rho GDP-Dissociation Inhibitor α suppresses Rac1 activation and podocyte injury. J Am Soc Nephrol (JASN). 2017 Dec;28(12):3545-3562. doi: 10.1681/ASN.2016091021. Epub 2017 Aug 3. PMID: 28775002.
88. Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 2018 Sep;25(9):1549-1566. doi: 10.1038/s41418-017-0049-4. Epub 2018 Jan 22. PMID: 29358671.
89. Fu X, Liang C, Li F, Wang L, Wu X, Lu A, Xiao G*, Zhang G*. The Rules and Functions of Nucleocytoplasmic Shuttling Proteins. Int J Mol Sci. 2018 May 12;19(5). pii: E1445. doi: 10.3390/ijms19051445. Review. PMID: 29757215.
90. Yi YS, Jian J, Gonzalez-Gugel E, Shi YX, Tian Q, Fu W, Hettinghouse A, Song W, Liu R, He M, Qi H, Yang J, Du X, Xiao G, Chen L, Liu CJ. p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice. EBioMedicine. 2018 Mar;29:78-91. doi: 10.1016/j.ebiom.2018.02.012. Epub 2018 Feb 16. PMID: 29472103.
91. Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, Yuan J, Zhang K, Liu Z, Deng Y, Xiao G, Wu C. Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ. J Cell Biol. 2018 Apr 2;217(4):1431-1451. doi: 10.1083/jcb.201612177. Epub 2018 Mar 1. PMID: 29496737.
92. Wang T, Li S, Yi D, Zhou GQ, Chang Z, Ma PX, Xiao G, Chen D. CHIP Regulates Bone Mass by Targeting Multiple TRAF Family Members in Bone Marrow Stromal Cells. Bone Res. 2018 Mar 29;6:10. doi: 10.1038/s41413-018-0010-2. eCollection 2018. PMID: 29619270.
93. Yang X, Xia R, Yue C, Zhai W, Du W, Yang Q, Cao H, Chen X, Obando D, Zhu Y, Chen X, Chen J, Piganelli J, Wipf P, Jiang Y, Xiao G, Wu C, Jiang J, Lu B. ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming. Cell Rep. 2018 May 8;23(6):1754-1766. doi: 10.1016/j.celrep.2018.04.032.
94. Chen H, Wang Y, Dai H, Tian X, Cui ZK, Chen Z, Hu L, Song Q, Liu A, Zhang Z, Xiao G, Yang J, Jiang Y, Bai X. Bone and plasma citrate is reduced in osteoporosis. Bone. 2018 Sep;114:189-197. doi: 10.1016/j.bone.2018.06.014. Epub 2018 Jun 19. PMID: 29929041.
95. Zhou Y, Shu B, Xie R, Huang J, Zheng L, Zhou X, Xiao G, Zhao L, Chen D. Deletion of Axin1 in condylar chondrocytes leads to osteoarthritis-like phenotype in temporomandibular joint via activation of β-catenin and FGF signaling. J Cell Physiol. 2019 Feb;234(2):1720-1729. doi: 10.1002/jcp.27043. Epub 2018 Aug 2. PMID: 30070692.
96. Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J, Xiao G, Tang B, Sun Y, Wu C. Kindlin-2 links mechano-environment to proline synthesis and tumor growth. Nat Commun. 2019 Feb 19;10(1):845. doi: 10.1038/s41467-019-08772-3. PMID: 30783087.
97. Zhao L, Huang J, Fan Y, Li J, You T, He S, Xiao G, Chen D. Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis. Ann Rheum Dis. 2019 May;78(5):676-682. doi: 10.1136/annrheumdis-2018-214724. Epub 2019 Mar 6. PMID: 30842121.
98. Liu W, Wang Z, Yang J, Wang Y, Li K, Huang B, Yan B, Wang T, Li M, Zou Z, Yang J, Xiao G, Cui ZK, Liu A, Bai X. Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice. Open Biol. 2019 May 31;9(5):180262. doi: 10.1098/rsob.180262. PMID: 31088250.
99. Huang J, Zhao L, Fan Y, Liao L, Ma PX, Xiao G, Chen D. The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression. Nat Commun. 2019 Jun 28;10(1):2876. doi: 10.1038/s41467-019-10753-5. PMID: 3125384.
100. Gao H, Guo Y, Yan Q, Yang W, Li R, Lin S, Bai X, Liu C, Chen D, Cao H, Xiao G. Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of Kindlin-2. JCI Insight. 2019 Jul 11;4(13). pii: 128405. doi: 10.1172/jci.insight.128405. eCollection 2019 Jul 11. PMID: 31292295.
101. Liu R, Chen Y, Fu W, Wang S, Cui Y, Zhao X, Lei ZN, Hettinghouse A, Liu J, Wang C, Zhang C, Bi Y, Xiao G, Chen ZS, Liu CJ. Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis. Ann Rheum Dis. 2019 Nov;78(11):1524-1535. doi: 10.1136/annrheumdis-2019-215543. Epub 2019 Jul 13. PMID: 31302596.
102. Wang Y, Yan Q, Zhao Y, Liu X, Lin S, Zhang P, Ma L, Lai Y, Bai X, Liu C, Wu C, Feng JQ, Chen D, Cao H, Xiao G. Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight. 2019 Nov 14;4(22). pii: 131692. doi: 10.1172/jci.insight.131692. PMID: 31723057.
103. Cao H, Yan Q, Wang D, Lai Y, Zhou B, Zhang Q, Jin W, Lin S, Lei Y, Ma L, Guo Y, Wang Y, Wang Y, Bai X, Liu C, Feng JQ, Wu C, Chen D, Cao X, Xiao G. Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Res. 2020 Jan 2;8(1):2. doi: 10.1038/s41413-019-0073-8. PMID: 31934494.
104. Cao H, Xiao G. Kindlin Signaling and Bone. Encyclopedia of Bone Biology, 2020, 449-460. Elsevier (https://doi.org/10.1016/B978-0-12-801238-3.11176-6)(Publisher: Academic Press)
105. Feng X, Pan J, Li J, Zeng C, Qi W, Shao Y, Liu X, Liu L, Xiao G, Zhang H, Bai X, Cai D. Metformin attenuates cartilage degeneration in experimental osteoarthritis via the regulation of AMPK/mTOR. Aging (Albany NY). 2020 Jan 16;12(2):1087-1103. doi: 10.18632/aging.102635. Epub 2020 Jan 16. PMID: 31945013.
106. Zhu K, Lai Y, Cao H, Liu C, Bai X, Yan Q, Ma L, Chen D, Kanaporis G, Wang J, Li L, Cheng T, Wang Y, Wu C, Xiao G. Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun. 2020 Jan 24;11(1):484. doi: 10.1038/s41467-019-14186-y.PMID: 31980627.
107. Yang H, Wen Y, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, Ye T, Bai X, Xiao G*, Wang M*. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21. PMID: 31007149.
108. Chen S, Qin L, Wu X, Fu X, Lin S, Chen D, Xiao G, Shao Z and Cao H. Moderate fluid shear stress regulates heme oxygenase-1 expression to promote autophagy and ECM homeostasis in the nucleus pulposus cells. Front Cell Dev Biol. 2020 Mar 3;8:127. doi: 10.3389/fcell.2020.00127. eCollection 2020. PMID: 32195253.
109. Li J, Zhang B, Liu W, Lu K, Pan Ha, Wang T, Yi D, Huang J, Zhao L, Ning G, Xing C, Xiao G, Liu-Bryan, R, Feng S, Chen D. Metformin limits osteoarthritis development and progression through activation of AMPK signaling. Ann Rheum Dis. 2020 May;79(5):635-645. doi: 10.1136/annrheumdis-2019-216713. Epub 2020 Mar 10. PMID: 32156705.
110. Shu B, Zhao Y, Zhao S, Pan H, Xie R, Yi D, Lu K, Yang J, Xue C, Huang J, Wang J, Zhao D, Xiao G, Wang Y, Chen D. Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation. Bone Res. 2020 Aug 12;8(1):31. doi: 10.1038/s41413-020-0104-5.PMID: 34381014.
111. Lei Y, Fu X, Li P, Lin S, Yan Q, Lai Y, Liu X, Wang Y, Bai X, Liu C, Chen D, Zou X, Cao X, Cao H, Xiao G. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Res. 2020 Oct 13;8:37. doi: 10.1038/s41413-020-00108-y. eCollection 2020. PMID: 33083097.
112. Lei Qin, Liu W. Cao H, Xiao G. Molecular mechanosensors in osteocytes. Bone Res. 2020 Jun 8;8(1):23. doi: 10.1038/s41413-020-0099-y. PMID: 34099619.
113. Fu X, Zhou B, Yan Q, Tao C, Qin L, Wu X, Lin S, Chen S, Lai Y, Zou X, Shao Z, Wang M, Chen D, Jin W, Song Y, Cao H, Zhang G, Xiao G. Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduct Target Ther (STTT). 2020 Dec 26;5(1):297. doi: 10.1038/s41392-020-00328-y.PMID: 33361757.
114. Qin L, Fu X, Ma J, Lin M, Zhang P, Wang Y, Yan Q, Tao C, Liu W, Tang B, Chen D, Bai X, Cao H, Xiao G. Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. Commun Biol. 2021 Mar 25;4(1):402. doi: 10.1038/s42003-021-01950-4. PMID: 33767359.
115. Xiao M, Zhang W, Liu W, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A, Song Q, Li Y, Xiao G, Zou Z, Bai X. Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment. Blood. 2021 Jun 24;137(25):3533-3547. doi: 10.1182/blood.2020007731.
116. Klionsky DJ…Xiao G…Guidelines for the use and interpretation of assays for monitoring autophagy (5th edition). Autophagy. 2021 Feb 8:1-382. doi: 10.1080/15548627.2020.1797280. PMID: 33634751.
117. Gong Y, Li Z, Zou S, Deng D, Lai P, Hu H, Yao Y, Hu L, Zhang S, Li K, Wei T, Zhao X, Xiao G, Chen Z, Jiang Y, Bai X, Zou Z. Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells. Developmental Cell. 2021 Jul 26;56(14):2103-2120.e9. doi: 10.1016/j.devcel.2021.06.011. Epub 2021 Jul 1. PMID: 34214490
118. Fu W, Hu W, Yi YS, Hettinghouse A, Sun G, Bi Y, He W, Zhang L, Gao G, Liu J, Toyo-Oka K, Xiao G, Solit DB, Loke P, Liu CJ. TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity. J Clin Invest. 2021 Aug 16;131(16):144016. doi: 10.1172/JCI144016.PMID: 34185706.
119. Gao H, Zhong Y, Ding Z, Lin S, Hou X, Tang W, Zhou X, Zou X, Shao J, Yang F, Bai X, Liu C, Cao H, Xiao G. Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice. Diabetes. 2021 Nov;70(11):2492-2505. doi: 10.2337/db21-0392. Epub 2021 Aug 11.PMID: 34380695
120. Qin L, Yang D, Yi W, Cao H, Xiao G. Roles of leader and follower cells in collective cell migration. Mol Biol Cell. 2021 Jul 1;32(14):1267-1272. doi: 10.1091/mbc.E20-10-0681.PMID: 34184941.
121. Zhang X, Li N, Zhang J, Zhang Y, Yang X, Luo Y, Zhang B, Xu Z, Zhu Z, Yang X, Yan Y, Lin B, Wang S, Chen D, Ye C, Ding Y, Lou M, Wu Q, Hou Z, Zhang K, Liang Z, Wei A, Wang B, Wang C, Jiang N, Zhang W, Xiao G, Ma C, Ren Y, Qi X, Han W, Wang C, Rao F. 5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab. 2021 Oct;3(10):1400-1414. doi: 10.1038/s42255-021-00468-7. Epub 2021 Oct 18. PMID: 34663975.
122. Qin L, He T, Chen S, Yang D, Yi W, Cao H, Xiao G. Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Bone Res. 2021 Oct 20;9(1):44. doi: 10.1038/s41413-021-00168-8. PMID: 34667178.
123. Chen G, Wang S, Long C, Wang Z, Chen X, Tang W, He X, Bao Z, Tan B, Lu W, Li Z, Yang D, Xiao G*, Peng S*. PiRNA-63049 inhibits bone formation through Wnt/β-catenin signaling pathway. Int J Biol Sci. 2021; 17 (15), 4409-4425. doi: 10.7150/ijbs.64533.
124. Wu X, Qu M, Gong W, Zhou C, Lai Y, Xiao G. Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice. J Orthop Translat. 2021 Sep 27;32:41-48. doi: 10.1016/j.jot.2021.08.005. eCollection 2022 Jan. PMID: 34934625.
125. Chen S, Chen M, Wu X, Lin S, Tao C, Cao H, Shao Z, Xiao G. Global, regional and national burden of low back pain 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019. J Orthop Translat. 2021 Sep 10;32:49-58. doi: 10.1016/j.jot.2021.07.005. eCollection 2022 Jan. PMID: 34934626.
126. Chen S, Wu X, Lai Y, Chen D, Bai X, Liu S, Wu Y, Chen M, Lai Y, Cao H, Shao Z, Xiao G. Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone Res. 2022 Jan 10;10(1):5. doi: 10.1038/s41413-021-00179-5. PMID: 35013104.(This article is highlighted by Nature Reviews Rheumatology: Attwaters, M. Kindlin-2 reduces IVD inflammation. Nat Rev Rheumatol. 2022 Jan 31. doi: 10.1038/s41584-022-00753-z. Online ahead of print. PMID: 35102297).
127. Wu X, Lai Y, Chen S, Zhou C, Tao C, Fu X, Li J, Tong W, Tian H, Shao Z, Liu C, Chen D, Bai X, Cao H, Xiao G. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nature Aging. 2022 Apr;2(4):332-347. doi: 10.1038/s43587-021-00165-w. Epub 2022 Feb 10. PMID: 37117739
128. Yan Q, Gao H, Ling K, Xiao G. Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling. J Biol Chem. 2022 Jan 25;298(3):101639. doi: 10.1016/j.jbc.2022.101639. Online ahead of print. PMID: 35090892. This article is featured by Medicine Innovates: https://medicineinnovates.com/loss-phosphatidylinositol-4-phosphate-5-kinase-type-1-gamma-pip5k1c-mesenchymal-stem-cells-leads-osteopenia-impairing-bone-remodeling/
129. Chen S, Gan D, Lin S, Zhong Y, Chen M, Zou X, Shao Z, Xiao G. Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics 2022; 12(6): 2722-2740. PMID: 35401820 PMCID: PMC8965502 DOI: 10.7150/thno.71360.
130. Gao H, Zhou L, Zhong Y, Ding Z, Lin S, Wu X, Zhou X, Zou X, Cao H, Xiao G. Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice. Nat Commun. 2022 Feb 23;13(1):1025. doi: 10.1038/s41467-022-28692-z. PMID: 35197460.
131. Wen C, Xiao G. Advances in osteoarthritis research in 2021 and beyond. J Orthop Translat. 2022 Mar 22;32:A1-A2. doi: 10.1016/j.jot.2022.02.011. eCollection 2022 Jan. PMID: 35591934.
132. Zhang H, Shao Y, Yao Z, Liu L, Zhang H, Yin J, Xie H, Li K, Lai P, Zeng H, Xiao G, Zeng C, Cai D, Bai X. Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7. Ann Rheum Dis. 2022 May;81(5):676-686. doi: 10.1136/annrheumdis-2021-221513. Epub 2022 Jan 20. PMID: 35058228.
133. Qin L, He T, Yang D, Wang Y, Zhang P, Li Z, Lin S, Gao H, Yao Q, Chen Z, Xu Z, Tang B, Yi W, Xiao G. Osteocyte b1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice. J Orthop Translat. 2022 May 17;34:60-72. doi: 10.1016/j.jot.2022.03.008. eCollection 2022 May. PMID: 35615639.
134. Liu G*, Xiao G*, Su J*, Xu R* and Xia Z*. Editorial: Tissue Stem Cells During Trauma: From Basic Biology to Translational Medicine. Front Cell Dev Biol. 2022 May 26;10:914582. doi: 10.3389/fcell.2022.914582. eCollection 2022. PMID: 35693930.
135. Lai Y, Zheng W, Xiao C, Qu M, Chen S, Yao Q, Gong W, Tao C, Yan Q, Zhang P, Wu X, Xiao G. Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice. Int J Oral Sci. 2022 Jul 4;14(1):33. doi: 10.1038/s41368-022-00185-1. PMID: 35788130.
136. Tong L, Yu H, Huang X, Shen J, Xiao G, Chen L, Wang H, Xing L, Chen D. Current understanding in the osteoarthritis pathogenesis and relevant new approaches. Bone Res. 2022 Sep 20;10(1):60. doi: 10.1038/s41413-022-00226-9. PMID: 36127328.
137. Zhao Y, Wang Y, Hu L, Chen H, Xiao X, Li Z, Feng M, Yang P, Liu P, Zhang S, Xiao G, Liu J, Shen J, Bai X. Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity. Biochem Biophys Res Commun. 2022 Sep 15;630:101-111. doi: 10.1016/j.bbrc.2022.09.042. Online ahead of print. PMID: 36152347.
138. Zhu Z, Huang Y, Li J, Yi D, Liao J, Xiao J, Xiao G, Tong L, Huang W, Chen D. AMPK Activator Decelerates Osteoarthritis Development by Inhibition of β-Catenin Signaling in Chondrocytes. J Orthop Translat. 2022 Nov 14;38:158-166. doi: 10.1016/j.jot.2022.10.005. eCollection 2023 Jan. PMID: 36439631.
139. Xie R, Yi D, Zeng D, Jie Q, Kang Q, Zhang Z, Zhang Z, Xiao G, Chen L, Tong L, Chen D. Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice. Elife. 2022 Dec 21;11:e80013. doi: 10.7554/eLife.80013. 2PMID: 36541713.
140. Tuan RS, Zhang Y, Chen L, Guo Q, Yung PS, Jiang Q, Lai Y, Yu J, Luo J, Xia J, Xu C, Lei G, Su J, Luo X, Zou W, Qu J, Song B, Zhao X, Ouyang H, Li G, Ding C, Wan C, Chan BP, Yang L, Xiao G, Shi D, Xu J, Cheung LW, Bai X, Xie H, Xu R, Li ZA, Chen D, Qin L. Current progress and trends in musculoskeletal research: Highlights of NSFC-CUHK academic symposium on bone and joint degeneration and regeneration. J Orthop Translat. 2022 Dec 16;37:175-184. doi: 10.1016/j.jot.2022.12.001. eCollection 2022 Nov. PMID: 36605329.
141. Qin L, Liu N, Bao C, Yang D, Ma G, Yi WH, Xiao G*, Cao H*. Mesenchymal stem cells in fibrotic diseases – the two sides of the same coin. Acta Pharmacologica Sinica (APS) (2023) 44:268–287; https://doi.org/10.1038/s41401-022-00952-0,PMID: 35896695.
142. Wu X, Lin S, Liao R, Yao Q, Lin L, Zou X and Xiao G. Brief research report: Effects of Pinch deficiency on cartilage homeostasis in adult mice. Front. Cell Dev. Biol. 2023 Jan 19;11:1116128. doi: 10.3389/fcell.2023.1116128. eCollection 2023. PMID: 36743414.
143. Gao H, Zhong Y, Zhou L, Lin S, Hou X, Ding Z, Li Y, Yao Q, Cao H, Zou X, Chen D, Bai X, Xiao G. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. Elife. 2023 Jan 9;12:e81792. doi: 10.7554/eLife.81792. PMID: 36622102.
144. Qu M, Chen M, Gong W, Huo S, Yan Q, Yao Q, Lai Y, Chen D, Wu X, Xiao G. Pip5k1c loss in chondrocytes causes spontaneous osteoarthritic lesions in aged mice. Aging Dis. 2023 Apr 1;14(2):502-514. doi: 10.14336/AD.2022.0828. eCollection 2023 Apr 1. PMID: 37008048 2022 https://doi.org/10.14336/AD.2022.0828.
145. Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M, Zhong Y, He T, Chen S, Xiao G. Osteoarthritis: pathogenic signaling pathways and therapeutic targets. Signal Transduct Target Ther (STTT) 2023 Feb 3;8(1):56. doi: 10.1038/s41392-023-01330-w. PMID: 36737426.
146. Xiao G. Editorial, 2023 January Issue Journal of Orthopaedic Translation. J Orthop Translat. 2023 Feb 15;38:A1-A3. doi: 10.1016/j.jot.2023.01.004. eCollection 2023 Jan. PMID: 36874059.
147. Yi W, Yang D, Xu Z, Chen Z, Xiao G*, Qin L*. Immortalization of mouse primary astrocytes. Gene. 2023 Mar 2:147327. doi: 10.1016/j.gene.2023.147327. Online ahead of print. PMID: 36870428
148. Lu K, Wang Q, Hao L, Wei G, Wang T, Xiao G, Tong L, Zhao X, Chen D. miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction. Bioact Mater. 2023 Mar 20;26:425-436. doi: 10.1016/j.bioactmat.2023.03.010. eCollection 2023 Aug. PMID: 36969105.
149. Chen S, He T, Zhong Y, Chen M, Yao Q, Chen D, Shao Z, Xiao G. Roles of focal adhesion proteins in skeleton and diseases. Acta Pharm Sin B. (APSB) 2023 Mar;13(3):998-1013. doi: 10.1016/j.apsb.2022.09.020. Epub 2022 Oct 3. PMID: 36970189.
150. Lu K, Wang Q, Jiang H, Li J, Yao Z, Huang Y, Chen J, Zhang J, Xiao G, Hu X, Luo Z, Yang L, Tong L, Chen D.Upregulation of b-catenin signaling represents a single, common pathway leading to the various phenotypes of spinal degeneration and pain. Bone Res. 2023 Apr 14;11(1):18. doi: 10.1038/s41413-023-00253-0. PMID: 37059724.
151. Yao Q, Gong W, Wu X, Gan D, Tao C, Lin S, Qu M, Ouyang Z, Chen M, Hu X, Xiao G. Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in mice. J Orthop Translat. 2023 May 31;41:12-19. doi: 10.1016/j.jot.2023.05.005. eCollection 2023 Jul. MID:37292436, PMCID: PMC10244901, DOI: 10.1016/j.jot.2023.05.005.
152. Qin L, Chen Z, Yang D, He T, Xu Z, Zhang P, Yi W, Xiao G. Osteocyte b3 integrin promotes bone mass accrual and force-induced bone formation in adult mice. J Orthop Translat. 2023 Jun 7;40:58-71. doi: 10.1016/j.jot.2023.05.001. eCollection 2023 May. PMID: 37457310
153. Xie X, Zhang W, Xiao M, Qiu J, Wang H, Qiu Z, Zhang S, Mao L, Wei T, Li Y, Hu S, Pan Y, Chen Z, Li L, Lu Y, Gong Y, Yang J, Xiao G*, Zhang Y*, Bai X*. TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia. Blood. 2023 Jun 29;141(26):3184-3198. doi: 10.1182/blood.2022018619. PMID: 37001042
154. Gao H, Zhong Y, Lin S, Yan Q, Yao Q, Zou X, Xiao G. Adipoq+ cell population controls bone mass via sclerostin in the bone microenvironment in mice. Signal Transduct Target Ther (STTT). 2023 Jul 10;8(1):265. doi: 10.1038/s41392-023-01461-0. PMID: 37423945. Paper of the Month - January 2024 selected by the BMAS Scientific Board (https://bma-society.org/paper-of-the-month/)
155. Wu X, Chen M, Lin S, Chen S, Gu J, Wu Y, Qu M, Gong W, Yao Q, Li H, Zou X, Chen D, Xiao G. Loss of Pinch Proteins Causes Severe Degenerative Disc Disease-Like Lesions in Mice. Aging Dis. 2023 Oct 1;14(5):1818-1833. doi: 10.14336/AD.2023.0212. PMID: 37196110
156. Chen S, Yang W, Chen M, Liu S, Shao Z, Xiao G. Regulated cell death in musculoskeletal formation, homeostasis, and diseases. Fundamental Research (2023).doi: https://doi.org/10.1016/j.fmre.2023.08.009
157. Lu K, Zhang M, Wei G, Xiao G, Tong L, Chen D. Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability. Elife. 2023 Nov 9;12:e80327. doi: 10.7554/eLife.80327. Online ahead of print. PMID: 37943017
158. Aging Biomarker Consortium, Jinlong Suo, Yibo Gan, Yangli Xie, Shuqin Xu, Jianfang Wang, Di Chen, Lin Chen, Lianfu Deng, Shiqing Feng, Jingdong Jackie Han, Qing Jiang, Guanghua Lei, Peng Liu, Xianghang Luo, Xin Ma, Jing Qu, Chunli Song, Peifu Tang, Tingting Tang, Sijia Wang, Xiaochun Wei, Chengtie Wu, Guozhi Xiao*, Liu Yang, Licheng Zhang, Weiqi Zhang, Zhenlin Zhang, Guang-Hui Liu, Changqing Zhang, Gang Pei, Jian Luo, Rui Yue, Weiguo Zou, A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine, 2023; lnad045, https://doi.org/10.1093/lifemedi/lnad045
159. Li J, Liu B, Wu H, Zhang S, Liang Z, Guo S, Jiang H, Song Y, Lei X, Gao Y, Cheng P, Li D, Wang J, Liu Y, Wang D, Zhan N, Xu J, Wang L, Xiao G, Yang L, Pei G. Sensory nerves directly promote osteoclastogenesis by secreting Peptidyl-prolyl cis-trans isomerase D (Cyp40). Bone Res. 2023 Dec 14;11(1):64. doi: 10.1038/s41413-023-00300-w. PMID: 38097598
160. Yi D, Jin H, Lu WW, Zhang C, Xiao G, Tong L, Chen D, Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice. Genes Dis. 2023 Oct 19;11(4):101147. doi: 10.1016/j.gendis.2023.101147. eCollection 2024 Jul.PMID: 38515941
161. Gan D, Jin X, Wang X, Tao C, Yan Q, Jia Q, Huo S, Chen D, Yao Q, Xiao G. Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization. Arthritis Res Ther. 2023 Dec 7;25(1):237. doi: 10.1186/s13075-023-03223-3.PMID: 38062473
162. Qin L, Xiao G. Primary astrocytes purification and immortalization. Curr Protoc. 2023 Dec;3(12):e964. doi: 10.1002/cpz1.964. PMID: 38131300
163. He T, Zhou B, Cheng H, Yan Q, Lin S, Ma G, Yao Q, Wu X, Zhong Y, Gan D, Huo S, Jin W, Chen D, Bai X, Cheng T, Cao H, Xiao G. The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway. Cell Death Differ. 2024 Jan;31(1):90-105. doi: 10.1038/s41418-023-01243-9. Epub 2023 Dec 7.
164. Zhong Y, Zhou L, Wang H, Lin S, Liu T, Kong X, Xiao G*, Gao H*. Kindlin-2 loss in hepatocytes causes liver dysfunction by stimulating oxidative stress and osteopontin-dependent inflammation in mice. J Biol Chem. 2024 Feb;300(2):105601. doi: 10.1016/j.jbc.2023.105601. Epub 2023 Dec 28. PMID: 38159860
165. Liao Z, Umar M, Huang X, Qin L, Xiao G, Chen Y, Tong L, Chen D. Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis. Cell Prolif. 2024 Mar;57(3):e13569. doi: 10.1111/cpr.13569. Epub 2023 Nov 23. PMID: 37994506
166. Yao Q, He T, Liao J, Liao R, Wu X, Lin L, Xiao G. Noncoding RNAs in the development and disorders of the skeletal system. Biol Res. 2024 Apr 22;57(1):16. doi: 10.1186/s40659-024-00497-y.PMID: 38644509
167. Huo S, Tang X, Chen W, Gan D, Guo H, Yao Q, Liao R, Huang T, Wu J, Yang J, Xiao G*, Han X*. Epigenetic regulations of cellular senescence in osteoporosis. Ageing Res Rev. 2024 Feb 15:102235. doi: 10.1016/j.arr.2024.102235. Online ahead of print.
168. Lin S, Tao C, Yan Q, Gao H, Qin L, Zhong Y, Yao Q, Zhang P, Yang J, Zou X, Xiao G. Pip5k1c expression in osteocytes regulates bone remodeling in mice. J Orthop Translat. 2024 Mar 8;45:36-47. doi: 10.1016/j.jot.2023.10.008. eCollection 2024 Mar. PMID: 38495744
169. Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, Duan X, Zhao X, Zhou W, Jiang Q, Xiao G, Zou W, Chen D, Zou Z, Bai X. An integrated multi-omics analysis reveals osteokines involved in global regulation. Cell Metab. 2024 Mar 28:S1550-4131(24)00085-8. doi: 10.1016/j.cmet.2024.03.006. Online ahead of print. PMID: 38574738
170. Chen H, Fu X, Wu X, Qiu F, Zhao J, Wang Z, Wang Z, Chen X, Xie D, Huang J, Fan J, Yang X, Song Y, Li J, He D, Xiao G*, Lu A*, Chao Liang X*. Integrative multi-omics approaches for identifying gut microbiota-derived propionate targeting synovial fibroblasts to ameliorate rheumatoid arthritis. Bone Res. 2024 May 23;12(1):31. doi: 10.1038/s41413-024-00336-6. PMID: 38782893
171. Gan D, Tao C, Jin X, Jia Q, Wu X, Yan Q, Zhong Y, Wu L, Huo S, Xiao G. Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin. J Adv Res. 62 (2024) 105–117. PMID: 37758057
172. Xie J, Liu X, Wu B, Chen B, Song Q, Guan Y, Gong Y, Yang C, Lin J, Huang M, Tan X, Lai R, Lin X, Zhang S, Xie X, Chen X, Zhang C, Yang M, Nong H, Zhao X, Xia L, Zhou W, Xiao G, Jiang Q, Zou W, Chen D, Lu D, Liu J, Bai X. Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients. Cell Rep Med. 2024 Jun 18;5(6):101588. doi: 10.1016/j.xcrm.2024.101588. Epub 2024 May 22. PMID: 38781961.
173. Chen M, Li F, Qu M, Jin X, He T, He S, Yao Q, Wang L, Chen D, Wu X, Xiao G. Pip5k1g promotes anabolism of nucleus pulposus cells and intervertebral disc homeostasis by activating CaMKII-Ampk pathway in aged mice. Aging Cell. 2024 Jun 5:e14237. doi: 10.1111/acel.14237. Online ahead of print. PMID: 38840443
174. Lu K, Zhang M, Qin H, Shen S, Song H, Jiang H, Zhang C, Xiao G, Tong L, Jiang Q, Chen D. Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma. Acta Pharmaceutica Sinica B (APSB) 2024 Jul;14(7):2977-2991. doi: 10.1016/j.apsb.2024.03.013. Epub 2024 Mar 10. PMID: 39027231
175. Tao C, Lin S, Shi Y, Gong W, Chen M, Li J, Zhang P, Yao Q, Qian D, Ling Z, Xiao G. Loss of Tnfr attenuates age-related intervertebral disc degeneration in mice. JOR Spine. 2024 Oct 8;7(4):e70006. doi: 10.1002/jsp2.70006. eCollection 2024 Dec. PMID: 39391171
176. Huang C, Zeng B, Zhou B, Chen G, Zhang Q, Hou W, Xiao G, Duan L, Hong N, Jin W, Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis. Genes Dis. 2024 Feb 2;12(2):101241. doi: 10.1016/j.gendis.2024.101241. eCollection 2025 Mar. PMID: 39759119
177. Yi D., Xie R., Zeng D., Jun Xiao J, Xiao G, Jin H, Tong L, Chen D (2024). Loss of Axin1 in limb mesenchymal cells leads to multiple synostoses syndrome-like phenotype in mice. The Innovation Medicine2(1): 100053. https://doi.org/10.59717/j.xinn-med.2024.100053
178. Zeng D, Yu J, Lu K, Yi D, Qin L, Xiao G, Yang X, Tong L, Chen D. Runx2 controls osteogenic fate of growth plate chondrocytes. Genes Dis. 2024 Nov 9;12(3):101453. doi: 10.1016/j.gendis.2024.101453. eCollection 2025 May. PMID: 39872471
179. Wang H, Feng N, Liu C, Xie Y, Zhou Z, Zhao H, Xiao G, Yang D. Inhibition of CSPG-PTPσ Activates Autophagy Flux and Lysosome Fusion, Aids Axon and Synaptic Reorganization in Spinal Cord Injury. Mol Neurobiol. 2025 Jan;62(1):773-785. doi: 10.1007/s12035-024-04304-3. Epub 2024 Jun 20. PMID: 38900368.
180. Li F, Chen M, Zhang M, Chen S, Qu M, He S, Wang L, Wu X, Xiao G. Targeting Piezo1 channel to alleviate intervertebral disc degeneration. J Orthop Translat. 2025 Mar 8;51:145-158. doi: 10.1016/j.jot.2025.01.006. eCollection 2025 Mar. PMID: 40129609
181. Shen Z, Zhang R, Chen X, Yang G, Si Y, Yan T, Chen S, Cheng B, Wu X, Chen D, Zhang D, Xiao G, Zhu JK, Wang S. An atlas of early human mandibular endochondral and osteogenic paracrine signaling regions of Meckel's cartilage. Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420466122. doi: 10.1073/pnas.2420466122. Epub 2025 Mar 17. PMID: 40096606
182. Chen S, Chen M, Chen C, Xie C, Yu Y, Shao Z, Xiao G. Evaluation of Osteoarthritis Disease Burden in China During 1990–2021. J Orthop Translat. 2025 Mar 17;51:218-226. doi: 10.1016/j.jot.2025.02.006. eCollection 2025 Mar. PMID: 40177637
183. He T, Qin L, Chen S, Huo S, Li J, Zhang F, Yi W, Mei Y, Xiao G. Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs. Bone Res. 2025 Apr 30;13(1):49. doi: 10.1038/s41413-025-00424-1. PMID: 40307216
184. Yang J, Yun X, Zheng W, Zhang H, Yan Z, Chen Y, Xue W, Mi S, Li Z, Sun H, Xiao G*, Dai Z*, Li S*, Huang W*. Nanoscale Engineered Exosomes for Dual Delivery of Sirtuin3 and Insulin to Ignite Mitochondrial Recovery in Myocardial Ischemia-reperfusion. J Nanobiotechnology. 2025 Jun 13;23(1):439. doi: 10.1186/s12951-025-03474-z. PMID: 40514650
185. Qin T, Shi M, Xie Y, Feng N, Liu C, Chen K, Chen Y, Zheng W, Zhu M, Peng S, Xiao G*, Long H*. Activation of LAMP1-mediated lipophagy by sulforaphane inhibits cellular senescence and intervertebral disc degeneration. J Orthop Translat. 2025 Jun 2; 53:12-25. doi: 10.1016/j.jot.2025.05.010. eCollection 2025 Jul. PMID: 40525097
186. Liao R, Li J, Xie C, Yan Q, Gan D, Xiao G*, Lin L*. Effects of tamoxifen on fetal cartilage development, adult cartilage metabolism and endochondral ossification in mice. Osteoarthritis Cartilage. 2025 Jun 13:S1063-4584(25)01054-4. doi: 10.1016/j.joca.2025.06.003. Online ahead of print. PMID: 40517943
187. Feng N, Liu C, Zhu Y, Cai S, Xie Y, Wang Z, Wang H, Xiao G*, Long H*, Peng S*. piENOX2 regulates ALKBH5-mediated Itga4 m6A modification to accelerate the progression of rheumatoid arthritis. Exp Mol Med. 2025 Jul;57(7):1579-1592. doi: 10.1038/s12276-025-01503-3. PMID: 40702135
Xiao Lab 光榮榜：
Xiaohao Wu, School of Medicine Dean’s Fellowship, Stanford University, $35,000, 2024；
Xiaohao Wu, Stanford Translational and Applied Medicine Pilot Grant, Stanford University, $20,000, 2024.
金小琬，南方科技大學(xué)2024年“藝術(shù)優(yōu)秀獎”研究生
金小琬，南方科技大學(xué)2024年“優(yōu)秀畢業(yè)研究生”
金小琬，南方科技大學(xué)2024年“優(yōu)秀碩士學(xué)位論文”
甘東浩，Postdoc, Yale University, 2024
河泰麟，南方科技大學(xué)2024年研究生“十佳畢業(yè)生”（博士研究生）候選人
鐘一鳴，首批國家自然科學(xué)基金青年學(xué)生基礎(chǔ)研究項目(博士研究生), 30萬, 2024
Talin He，The 5th ICMRC Presidential Award; oral presentation; the highest ranking abstract from about 600 abstracts, 2024
Jiaming Yang，The 5th ICMRC Young Investigator Award, 2024
陳明玨，南方科技大學(xué)醫(yī)學(xué)院第三屆“未來之星”論壇，三等獎, 2023
淘楚，南方科技大學(xué)醫(yī)學(xué)系統(tǒng)學(xué)術(shù)年會，三等獎， 2023
河泰麟，南方科技大學(xué)醫(yī)學(xué)系統(tǒng)學(xué)術(shù)年會，優(yōu)秀獎，2023
鐘一鳴，博士研究生國家獎學(xué)金, 2023
Donghao Gan, ASBMR Young Investigator Award, 2023
Talin He，ICMRS Webster Jee Young Investigator Award, oral presentation, 2023
吳曉昊，Postdoc, Stanford University, 2023
吳曉昊，南方科技大學(xué)2023年研究生“十佳畢業(yè)生” (博士研究生)
吳曉昊，南方科技大學(xué)醫(yī)學(xué)院“院長獎”，2023
吳曉昊，2022年“廣東省生命健康研究生學(xué)術(shù)論壇”口頭報告一等獎, 2023
Donghao Gan, ICMRS Webster Jee Young Investigator Award, oral presentation, 2023
姚青, 國自然面上基金, 53萬，2022
河泰麟，南方科技大學(xué)醫(yī)學(xué)院，優(yōu)秀博士生，2022
陳明玨，南方科技大學(xué)醫(yī)學(xué)院，優(yōu)秀研究生，2022
鐘一鳴，南方科技大學(xué)醫(yī)學(xué)院“院長獎”，2022
河泰麟，南方科技大學(xué)醫(yī)學(xué)院2021度優(yōu)秀研究生，2022
鐘一鳴，南方科技大學(xué)校級碩士學(xué)位論文，2022
鐘一鳴，南方科技大學(xué)校級優(yōu)秀研究生畢業(yè)生，2022
鐘一鳴，南方科技大學(xué)2022年研究生“十佳畢業(yè)生”（碩士研究生）
甘東浩，教育部博士后基金, 8萬，2022
Mingjue Chen, ICMRS Webster Jee Young Investigator Award, oral presentation, 2022
陳明玨，碩士研究生國家獎學(xué)金, 2022
吳曉昊，博士研究生國家獎學(xué)金, 2022
陳明玨，南方科技大學(xué)醫(yī)學(xué)院第二屆“未來之星”論壇，二等獎, 2022
甘東浩，第二屆南方科技大學(xué)醫(yī)療系統(tǒng)學(xué)術(shù)年會, 二等獎, 2022
林嗣雄，第二屆南方科技大學(xué)醫(yī)療系統(tǒng)學(xué)術(shù)年會, 三等獎，2022
Lei Qin, ASBMR Young Investigator Award, oral presentation,, 2021
曹惠玲, 科技部重大專項, 67萬，2021
王依姝，教育部博士后基金, 8萬，2021
Xiaohao Wu, ASBMR Felix Bronner Young Investigator Award; the highest ranking abstract from more 1000 abstracts, 2021
鐘一鳴 南方科技大學(xué)生命科學(xué)學(xué)院第二屆“學(xué)術(shù)之星”論壇優(yōu)秀獎，2021
Xiaohao Wu, ICMRS Webster Jee Young Investigator Award, oral presentation,, 2021
陳明玨，研究生國家獎學(xué)金，2021
高煥慶，首屆南方科技大學(xué)醫(yī)學(xué)系統(tǒng)學(xué)術(shù)年會，一等獎， 2021
吳曉昊，首屆南方科技大學(xué)醫(yī)學(xué)系統(tǒng)學(xué)術(shù)年會，三等獎， 2021
陳勝，首屆南方科技大學(xué)醫(yī)學(xué)系統(tǒng)學(xué)術(shù)年會，優(yōu)秀獎，2021
郭禺熙, 生物系優(yōu)秀畢業(yè)生, 2020
李茹璇, 校十佳畢業(yè)生候選人, 校級優(yōu)秀畢業(yè)生, 2020
李鵬宇, 生物系優(yōu)秀畢業(yè)生, 2020
吳曉昊 南方科技大學(xué)生命科學(xué)學(xué)院首屆“學(xué)術(shù)之星”論壇三等獎，2020
秦雷，教育部博士后基金, 8萬，2020
姚青, 深圳市科創(chuàng)委穩(wěn)定支持，面上項目, 50萬，2020
曹惠玲, 國自然面上基金, 55萬，2020
曹惠玲, 國自然優(yōu)秀青年基金獲得者, 120萬, 2020
Yishu Wang, ASBMR Young Investigator Award, Oral Presentation, 2019
王依姝，博士研究生國家獎學(xué)金, 2019
Yiming Lei, ASBMR Education Emerging Country Young Investigator Award，2019
Yiming Lei, ICMRS, Third Young Investigator Prize, oral presentation, 2019
Lei Qin, ICMRS, First Young Investigator Prize, oral presentation, 2019
劉鑫, 校十佳畢業(yè)生候選人，校級優(yōu)秀畢業(yè)生, 2019
曹惠玲, 深圳市科創(chuàng)委自由探索基金, 50萬，2019
高煥慶, 深圳市科創(chuàng)委基金, 40萬，2019
Huiling Cao, ICMRS Webster Jee Travel Award, 2018
Xin Liu, ASBMR Travel Award, Plenary Poster, 2017
Xin Liu, ICMRS, First Young Investigator Prize, oral presentation, 2017
Huiling Cao, ICMRS, First Young Investigator Prize, oral presentation, 2017
Huiling Cao, ASBMR, Plenary Poster, 2017
Huiling Cao, ASBMR Travel Award, Plenary Poster, 2016
曹惠玲, 國自然青年基金, 21.16萬，2016