師資
Zhang Wenyong教授為南方科技大學(xué)醫(yī)學(xué)院副院長、教授，博士生導(dǎo)師。他畢業(yè)于美國Bowdoin College，獲生物化學(xué)學(xué)士學(xué)位。之后獲得美國國立衛(wèi)生院醫(yī)學(xué)科學(xué)家培養(yǎng)基金，進入著名的“康奈爾醫(yī)學(xué)院、洛克菲勒大學(xué)、斯隆凱特琳癌癥中心—三校MD-PhD Program”攻讀醫(yī)學(xué)博士和生物學(xué)博士雙學(xué)位，于2004年以優(yōu)異成績畢業(yè)，獲得The Herman L. Jacobius 病理學(xué)獎。在攻讀生物學(xué)博士期間，在何大一醫(yī)學(xué)博士實驗室，從事HIV DNA疫苗的研發(fā)工作，獲得Elizabeth Glaser Pediatric AIDS Foundation Student Award。醫(yī)學(xué)院畢業(yè)后他在康奈爾大學(xué)醫(yī)學(xué)院紐約長老會醫(yī)院病理系接受了病理學(xué)的住院醫(yī)師培訓(xùn)，并獲得了紐約州的行醫(yī)執(zhí)照。隨后他到休斯頓貝勒醫(yī)學(xué)院、MD安德森癌癥研究中心、德州兒童醫(yī)學(xué)中心進行了分子病理學(xué)的進修。他分別在西奈山醫(yī)學(xué)院任病理系分子病理實驗室副主任，及紐約醫(yī)學(xué)院附屬醫(yī)院病理系任分子病理實驗室主任。在分子病理學(xué)的研究成果發(fā)表在《Journal of Clinical Oncology》、《American Journal of Pathology》、《Modern Pathology》、《Blood》等雜志上。他有豐富的教學(xué)經(jīng)驗，在西奈山醫(yī)學(xué)院和紐約醫(yī)學(xué)院分別教授醫(yī)學(xué)院學(xué)生、病理系住院醫(yī)師、分子病理進修醫(yī)生不同層次的病理學(xué)課程，并負(fù)責(zé)指導(dǎo)分子病理進修醫(yī)生的科研工作。為深圳市孔雀計劃B類人才，國家科技庫專家、教育部科技管理信息系統(tǒng)專家?guī)鞂＜摇V東省科技廳專家、深圳市科創(chuàng)委重大項目評審專家、北京4P健康研究院理事及專家委員會委員等。
研究領(lǐng)域
1、分子病理學(xué)
2、衰老機制及干預(yù)手段研究
3、系統(tǒng)生物學(xué)與癌癥預(yù)防研究
4、人工智能在疾病診斷中的應(yīng)用
學(xué)術(shù)論文
ZHANG WENYONG教授證明了利用融合基因方法，使得抗原靶向進入樹突狀細(xì)胞可以增強HIV DNA疫苗的活性。他在AIDS領(lǐng)域的研究讓他獲得了Elizabeth Glaser Pediatric AIDS Foundation Student Award，研究發(fā)表在Science、Vaccine、JAIDS等雜志上。他研發(fā)了針對多個癌癥靶向基因的簡易、高效、精確的檢測方法，包括BRAFV600E, MPLW515L/K, EWSR1/ATF1, EWSR1/CREB1, JAK2V617F等。在分子病理學(xué)的研究成果發(fā)表在《Journal of Clinical Oncology》、《American Journal of Pathology》、《Modern Pathology》、《Blood》等雜志上。
目前他擔(dān)任Association for Molecular Pathology及American Society of Clinical Pathology學(xué)會會員，《American Journal of Pathology》、《Archive of Pathology》、《Journal of Molecular Pathology》等雜志審稿人。
代表性文章
Meng T., Lan Z., Zhao X., Niu L., Chen C., & Zhang W. Comprehensive bioinformatics analysis of functional molecules in colorectal cancer. Journal Of Gastrointestinal Oncology 2022, 13(1), 231-245.
Luan H, Gu W, Li H, Wang Z, Lu L, Ke M, Lu J, Chen W, Lan Z, Xiao Y, Xu J, Zhang Y, Cai Z, Liu S, Zhang W. Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients. J Transl Med. 2021 Dec 7;19(1):500.
Qin J, Shi X, Xu J, Yuan S, Zheng B, Zhang E, Huang G, Li G, Jiang G, Gao S, Tian C, Guo R, Fu Z, Huang Q, Yang R, Zhang W, Li S, Wu S. Characterization of the Genitourinary Microbiome of 1,165 Middle-Aged and Elderly Healthy Individuals. Front Microbiol. 2021 Aug 19;12:673969.
Zhao X, Li Z, Wang L, Lan Z, Lin F, Zhang W, Su Z. A Chinese family with Noonan syndrome caused by a heterozygous variant in LZTR1: a case report and literature review. BMC Endocr Disord. 2021 Jan 6;21(1):2.
Ying Liu, Zhangzhang Lan , Fang Zhao, Shuangchuan Zhang, Wenyong Zhang. Analysis of a Chinese pedigree with familial chylomicronemia syndrome reveals two novel LPL mutations by whole-exome sequencing. Frontiers in Genetics 2020 Jul 17;11:741.
Min Li; Haitao Jia; Qiuqin Qian; Peng Wen; Chuan Chen; Yaqiong Hua; Kai Wang; Wenyong Zhang; Feng Shi. Genomic Characterization of High-Recurrence Risk Papillary Thyroid Carcinoma in Southern Chinese populations. Diagnostic Pathology 2020 15:49.
Luan H, Jiang X, Ji F, Lan Z, Cai Z, Zhang W. CPVA: a web-based metabolomic tool for chromatographic peak visualization and annotation. Bioinformatics. 2020 Mar 18. pii: btaa200.
Ou J, Yang C, Cui X, Chen C, Ye S, Zhang C, Wang K, Chen J, Zhang Q, Qian C, Fang G, Zhang W. Successful pregnancy after prenatal diagnosis by NGS for a carrier of complex chromosome rearrangements. Reprod Biol Endocrinol. 2020 Feb 29;18(1):15.
Geng Q, Cui X, Zhang Y, Zhang L, Zhang C, Wang K, Chen J, Zhu Q, Xie J, Xu Z, Liu Y, Zhang M, Ding L, Zhang W, Yang C. Screening of Triploid with Low-coverage Whole-genome Sequencing by A Single-nucleotide Polymorphism-based Test in Miscarriage Tissue J Assist Reprod Genet. 2019 Dec;36(12):2525-2531.
Luo A, Cheng D, Yuan S, Li H, Du J, Zhang Y, Yang C, Lin G, Zhang W, Tan YQ. Maternal interchromosomal insertional translocation leading to 1q43-q44 deletion and duplication in two siblings. Mol Cytogenet. 2018 Apr 4;11:24 (共同通訊作者).
T. Huang, J. Zhuge, W. Zhang. Sensitive detection of BRAF V600E mutation by Amplification Refractory Mutation System (ARMS)-PCR. Biomarker Research 2013; 1:3.
Li Z, Cai X, Cai CL, Wang J, Zhang W, Petersen BE, Yang FC, Xu M. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011 Oct 27;118(17):4509-18.
L. Varricchio, E. Masselli, E. Alfani, W. Zhang, R. Hoffman, AR Migliaccio. The dominant negative b isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells. Blood 2011, 118(2): 425-36.
J. Zhuge, W. Zhang. Sensitive detection of MPLW515L/K mutations by amplification refractory mutation system (ARMS)-PCR. Clinica Chimica Acta 2010; 411:122-123.
W. Zhang, D. Jones. Predictors of primary imatinib resistance in chronic myeloid leukemia are distinct from those in secondary resistance. J Clin Oncology. 2009; 27: 3642-3649.
W. Zhang, D. López-Terrada. Molecular monitoring of 8p11 myeloproliferative syndrome in an infant. J Pediatr Hematol Oncol 2009;31:879-883.
Wenyong W. Zhang, Jorge E. Cortes, Hui Yao, Li Zhang, Neelima G. Reddy, Elias Jabbour, Hagop M. Kantarjian, and Dan Jones. Predictors of Primary Imatinib Resistance in Chronic Myelogenous Leukemia Are Distinct From Those in Secondary Imatinib Resistance.J Clin Oncology. 2009 Aug 1;27(22):3642-9
W. Wang, E. Mayordomo, W. Zhang, V. S. Hernandez, D. Tuvin, L. Garcia, D. C. Lev, A. J. F. Lazar, D. López-Terrada. Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in Clear Cell Sarcoma (Melanoma of Soft Parts). Modern Pathology 2009; 22:1201-1209.
Z. Chen, W. Zhang, D. Ho. Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'. JAIDS 2008; 47: 412-421.
Y. Huang, Z. Chen, W. Zhang, D. Gurner, Y. Song, D. Gardiner, D. D. Ho. Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant. JAIDS 2008; 47: 403-411.
Y. Huang, A. Chen, X. Li, Z. Chen, W. Zhang, Y. Song, D. Gurner, D. Gardiner, S. Basu, D. D. Ho and M. Tsuji. Enhancement of HIV DNA vaccine immunogenicity by the NK T cell ligand, -galactosylceramide. Vaccine 2008; 26:1807-1816.
W. Zhang, J. Versalovic. Expanding the diagnostic capabilities of molecular microbiology by genomic methods. Journal of Molecular Diagnostics 2007; 9(5): 572-573.
W. Zhang, J. E. Dahlberg, W. Tam. MicroRNAs in tumorigenesis: a primer for pathologists. American Journal of Pathology 2007; 171(3):728-738.
W. Zhang, H. Syed. Mammary small cell carcinoma with dimorphic phenotype. Breast Journal 2007; 13(5): 529-530.
L. Zhang, W. Yu, T. He, J. Yu, R. E. Caffrey, E. A. Dalmasso, S. Fu, T. Pham, J. Mei, J. J. Ho, W. Zhang, P. Lopez, D. D. Ho. Contribution of human {alpha}-Defensin-1, -2 and -3 to the anti-HIV-1 activity of CD8 antiviral factor. Science 2002; 298:995-1000.
B. Stibrková, J. Majewski, I. Sebesta, W. Zhang, J. Ott, S. Kmoch. Familial juvenile hyperuricemic nephropathy: localization of the gene on chromosome 16p11.2-and evidence for genetic heterogeneity. Am. J. Human Genetics 2000; 66:1989-1994
論著
Zhuge, W. Zhang. Principles of molecular biology in Molecular Diagnosis of Skin Diseases (M. Murphy, ed). Humana Press (2011).