師資
基本概況：
葉建淮，南方科技大學(xué)環(huán)境科學(xué)與工程學(xué)院副教授（研究員、博士生導(dǎo)師），國家級青年人才。2017年博士畢業(yè)于多倫多大學(xué)，隨后于哈佛大學(xué)從事大氣化學(xué)博士后研究工作。主要研究方向包括大氣污染物排放特征表征、大氣污染形成機(jī)制及其環(huán)境氣候效應(yīng)、大氣污染物化學(xué)傳感器的開發(fā)與應(yīng)用等。發(fā)表論文50余篇，其中第一/通訊作者論文發(fā)表在PNAS、Nature Communications、Environmental Science & Technology、Geophysical Research Letters、Atmospheric Chemistry and Physics等大氣環(huán)境領(lǐng)域知名期刊。曾獲Atmosphere Young Investigator Award（2022）、 NSERC Postdoctoral Fellow（2020）、大氣化學(xué)研討會(huì)新興科學(xué)家（2019）、Camille & Henry Dreyfus Environmental Chemistry Postdoctoral Fellow（2017）等，主持國家自然科學(xué)基金青年、面上、深圳市自然科學(xué)基金面上等多項(xiàng)國家級和省市級項(xiàng)目。擔(dān)任ACS ES&T Air和《地球化學(xué)》青年編委、以及Frontiers in Forests and Global Change、Air Quality, Atmosphere & Health副主編。
工作經(jīng)歷：
2022.12–今 南方科技大學(xué)，副教授（研究員）
2021.06–2022.11 南方科技大學(xué)，助理教授（副研究員）
2017.08–2021.04 哈佛大學(xué)，博士后研究員
教育背景：
2013.09–2017.11 博士，多倫多大學(xué)（加拿大）
2010.10–2012.09 碩士，廣島大學(xué)（日本）
2006.09–2010.07 本科，北京化工大學(xué)
代表性項(xiàng)目：
1. 國家自然科學(xué)基金面上項(xiàng)目，大氣含氮有機(jī)氣溶膠生成及其理化性質(zhì)的環(huán)境因子調(diào)控機(jī)制研究，2024.01-2027.12，50萬，在研，主持
2. 國家自然科學(xué)基金青年科學(xué)基金項(xiàng)目，基于無人機(jī)技術(shù)對典型森林及城市大氣半揮發(fā)性有機(jī)物氣粒分配機(jī)制的觀測研究，2022.01-2024.12，30萬，在研，主持
3. 深圳市自然科學(xué)基金高等院校穩(wěn)定支持計(jì)劃面上項(xiàng)目，基于NO3自由基氧化的夜間大氣含氮有機(jī)氣溶膠生消機(jī)制研究，2022.10-2024.09，50萬，在研，主持
4. Green Tech Fund，Portable and low-cost sensors for the ambient air monitoring of BTEX and other volatile organic compounds，2022.04-2024.04，HK$569萬，在研，core member
教學(xué)情況：
地球科學(xué)概論（本科生課程）
研究方向：
1. 大氣污染物排放特征表征
2. 大氣污染形成機(jī)制及其環(huán)境氣候效應(yīng)
3. 大氣污染物化學(xué)傳感器的開發(fā)與應(yīng)用
學(xué)術(shù)成果：
(截止至2023年9月，#: 共同一作, *: 共同通訊)
1. Zhai, J.; Yu, G.; Zhang, J.; Shi, S.; Yuan, Y.; Jiang, S.; Xing, C.; Cai, B.; Zeng, Y.; Wang, Y.; Zhang, A.; Zhang, Y.; Fu, T.; Zhu, L.; Shen, H.; Ye, J.; Wang, C.; Tao, S.; Li, M.; Zhang, Y.; Yang, X., Impact of Ship Emissions on Air Quality in the Greater Bay Area in China under the Latest Global Marine Fuel Regulation. Environmental Science & Technology, 2023, 57, 12341-12350
2. 賈天蛟, 葛艷麗, 劉奔, 孫嘉胤, 吳雯潞, 葉建淮, 吳晟, 黎永杰, 傅宗玫, 陳琦. 嶺南亞熱帶森林冠層大氣揮發(fā)性有機(jī)物污染特征及區(qū)域人為源的影響. 環(huán)境工程技術(shù)學(xué)報(bào), 2023, 13, 473-482
3. Zhai, J.; Yang, X.; Li, L.; Ye, X.; Chen, J.; Fu, T.-M.; Zhu, L.; Shen, H.; Ye, J.; Wang, C.; Tao, S., Direct Observation of the Transitional Stage of Mixing-State-Related Absorption Enhancement for Atmospheric Black Carbon. Geophysical Research Letters, 2022, 49, e2022GL101368.
4. Fan, F.; Feng, Y.; Feng, J.; Hu, M.; Ye, J.; Tian, M.; Chen, J.; Wang, S.; Fu, Q., Molecular Tracer Characterization during COVID-19 Pandemic in Shanghai: Changes in the Aerosol Aqueous Environment and Implications for Secondary Organic Aerosol Formation. ACS Earth and Space Chemistry, 2022, 6, 2812-2825
5. Chu, C-W.; Zhai, J.; Han, Y.; Ye, J.; Li, K.; Zaveri, R.; Scot, M.; Hung, H-M., New particle formation and growth dynamics for pinene ozonolysis in a smog chamber and implications for ambient environments. ACS Earth and Space Chemistry, 2022, 6, 2826-2835
6. Zhang, J.; Wang, J.; Sun, Y.L.; Li, J.; Ninneman, M.; Ye, J.; Li, K.; Crandall, B.; Mao, J.; Xu, W.; Schwab, M.; Li, W.; Ge, X.; Chen, M.; Ying, Q.; Zhang, Q.; Schwab, J., Insights from ozone and particulate matter pollution control in New York City applied to Beijing. npj Climate and Atmospheric Science, 2022, 5, s41612-022-00309-8
7. Ohno, P.; Wang, J.; Mahrt, F.; Varelas, J.G.; Aruff, E.; Ye, J.; Qin, Y.; Kiland, K.J.; Bertram, A.K.; Thomson, R.J.; Martin, S.T., Gas-particle uptake and hygroscopic growth by organosulfate particles. ACS Earth and Space Chemistry, 2022, 6, 2481-2490
8. Ye, J.; Batista, C.E.; Zhao, T.; Campos, J.; Ma, Y.; Guimar?es, P.; Ribeiro, I.O.; Medeiros, A.S.S.; Stewart, M.P.; Vilà-Guerau de Arellano, J.; Guenther, A.B.; Souza, R.A.F.; Martin, S.T., River winds and transport of forest volatiles in the Amazonian riparian ecoregion. Environmental Science & Technology, 2022, 56, 12667-12677 Journal cover
9. Long, X.; Fu, T.-M.; Yang, X.; Tang, Y.; Zheng, Y.; Zhu, L.; Shen, H.; Ye, J.; Wang, C.; Wang, T.; Li, B., Efficient atmospheric transport of microplastics over Asia and adjacent oceans. Environmental Science & Technology, 2022, 56, 6243-6252
10. Aruff, E.; Wang, J.; Ye, J.; Ohno, P.; Qin, Y.; Stewart, M.; McKinney, K.; Di Carlo, P.; Martin, S. T., Partitioning of organonitrates in the production of secondary organic aerosols from α-pinene photo-oxidation. Environmental Science & Technology, 2022, 56, 5421-5429
11. Qin, Y.; Ye, J.; Ohno, P.; Liu, P.; Wang, J.; Fu, P.; Zhou, L.; Li, Y. J.; Martin, S. T.; Chan, C. K., Assessing the nonlinear effect of atmospheric variables on primary and oxygenated organic aerosol concentration using machine learning. ACS Earth and Space Chemistry, 2022, 6, 1059-1066
12. Shrivastava, M.; Rasool, Q.; Zhao, B.; Octaviani, M.; Zaveri, R.; Zelenyuk, A.; Gaudet, B.; Liu, Y.; Shilling, J.; Schneider, J.; Schulz, C.; Z?ger, M.; Martin, S.; Ye, J.; Guenther, A.; Souza, R.; Wendisch, M.; P?schl, U., Tight coupling of surface and in-plant biochemistry and convection governs key fine particulate components over the Amazon Rainforest. ACS Earth and Space Chemistry, 2022, 6, 380-390 Journal cover
13. Ma, Y.; Xin, J.; Wang, Z.; Tian, Y.; Wu, L.; Tang, G.; Zhang, W.; Vilà-Guerau de Arellano, J.; Zhao, D.; Jia, D.; Ren, Y.; Gao, Z.; Shen, P.; Ye, J.; Martin, S., How do aerosols above the residual layer affect the planetary boundary layer height? Science of the Total Environment, 2022, 814, 151953
14. Wang, J.; Ge, X.; Sonya, C.; Ye, J.; Lei, Y.; Chen, M.; Zhang, Q., Influence of regional emission controls on the chemical composition, sources, and size distributions of submicron aerosols: Insights from the 2014 Nanjing Youth Olympic Games. Science of the Total Environment, 2022, 807, 150869
15. Qin, Y.; Ye, J.; Ohno, P.; Nah, T.; Martin, S., Temperature-dependent viscosity of organic materials characterized by atomic force microscope. Atmosphere, 2021, 12, 1476
16. Zhao, T.; Ye, J.; Ribeiro, I.O.; Ma, Y.; Hung H.-M.; Batista, C.E.; Stewart, M.P.; Guimar?es, P.C.; Vilà-Guerau de Arellano, J.; Souza, R.; Martin, S.T., River winds and pollutant recirculation near the Manaus city in the central Amazon. Communications Earth & Environment, 2021, 2, 205
17. Qin, Y.; Ye, J.; Ohno, P.; Zhai, J.; Han, Y.; Liu, P.; Wang, J.; Zaveri, R.; Martin, S., Humidity dependence of the condensational growth of α-pinene secondary organic aerosol particles. Environmental Science & Technology, 2021, 55, 14360-14369
18. Liu, H.; Wang, Q.; Ye, J.; Su, X.; Zhang, T.; Zhang, Y.; Tian, J.; Dong, Y.; Chen, Y.; Zhu, C.; Han, Y.; Cao, J., Changes in source-specific black carbon aerosol and the induced radiative effects due to the COVID-19 lockdown. Geophysical Research Letters, 2021, 48, e2021GL092987.
19. Ohno, P. E.; Qin, Y.; Ye, J.; Wang, J.; Bertram, A. K.; Martin, S. T., Fluorescence aerosol flow tube spectroscopy to detect liquid–liquid phase separation. ACS Earth and Space Chemistry, 2021, 5, 1223-1232.
20. Liu, D.; Li, S.; Hu, D.; Kong, S.; Cheng, Y.; Wu, Y.; Ding, S.; Hu, K.; Zheng, S.; Yan, Q.; Zheng, H.; Zhao, D.; Tian, P.; Ye, J.; Huang, M.; Ding, D., Evolution of aerosol optical properties from wood smoke in real atmosphere influenced by burning phase and solar radiation. Environmental Science & Technology, 2021, 55, 5677-5688.
21. Li, S.; Liu, D.; Hu, D.; Kong, S.; Wu, Y.; Ding, S.; Cheng, Y.; Qiu, H.; Zheng, S.; Yan, Q.; Zheng, H.; Hu, K.; Zhang, J.; Zhao, D.; Liu, Q.; Sheng, J.; Ye, J.; He, H.; Ding, D., Evolution of organic aerosol from wood smoke influenced by burning phase and solar radiation. Journal of Geophysical Research: Atmospheres, 2021, 126, e2021JD034534.
22. Wang, J.#; Ye, J.#; Zhang, Q.; Zhao, J.; Wu, Y.; Li, J.; Liu, D.; Li, W.; Zhang, Y.; Wu, C.; Xie, C.; Qin, Y.; Lei, Y.; Guo, J.; Liu, P.; Li, Y.; Lee, H.C.; Hwang, S.; Zhang, J.; Liao, H.; Chen, M.; Sun, Y.; Ge, X.; Martin, S.T.; Jacob, D.J., Aqueous production of secondary organic aerosol from fossil fuel emissions in winter Beijing haze. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118, e2022179118 Highly cited article & hot paper
23. Ma, Y.#; Ye, J.*#; Ribeiro, I.O.; Vilà-Guerau de Arellano, J.; Xin, J.; Martin, S.T.*, Optimization and representativeness of atmospheric chemical sampling by hovering unmanned aerial vehicles over tropical forests. Earth and Space Science, 2021, 8, e2020EA001335
24. Wang, J.; Lei, Y.; Chen, Y.; Wu, Y.; Ge, X.; Shen, F.; Zhang, J.; Ye, J.; Nie, D.; Zhao, X.; Chen, M., Comparison of air pollutants and their health effects in two developed regions in China during the COVID-19 pandemic. Journal of Environmental Management, 2021, 287, 112296
25. Li, Y.; Liu, B.; Ye, J.; Jia, T.; Khuzestani, R.B.; Sun, J.Y.; Cheng, X.; Zheng, Y.; Wu, Cheng.; Xin, J.; Martin, S.T.; Li, Y.J.; Chen, Q., Unmanned aerial vehicle (UAV) measurements of volatile organic compounds over a subtropical forest in China and implications for emission heterogeneity. ACS Earth and Space Chemistry, 2021, 5, 247-256
26. Ye, J.*; Batista, C.E.; Guimar?es, P.C.; Ribeiro, I.O.; Vidoudez, C.; Barbosa, R.G.; Oliveria, R.L.; Ma, Y.; Jardin, K.J.; Surratt, J.D.; Guenther, A.B.; Souza, R.A.F.; Martin, S.T.*, Near-canopy horizontal concentration heterogeneity of semivolatile oxygenated organic compounds and implications for 2-methyltetrols primary emissions. Environmental Science: Atmospheres, 2021, 1, 8-20 Best paper 2021, journal cover, and highlighted by U.S. National Science Foundation
27. Wang, Q.; Liu, H.; Ye, J.; Tian, J.; Zhang, Y.; Wang, M.; Liu, S.; Cao, J., Estimating absorption ?ngstr?m exponent of black carbon aerosol by coupling multiwavelength absorption with chemical composition. Environmental Science & Technology Letters, 2020, 8, 121-127
28. Wang, Q.; Li, L.; Zhou, J.; Ye, J.; Liu, H.; Zhang, Y.; Zhang, R.; Tian, J.; Chen, Y.; Wu, Y.; Ran, W.; Cao, J., Measurement report: Evaluation of sources and mixing state of black carbon aerosol under the background of emission reduction in the North China Plain: implications for radiative effect. Atmospheric Chemistry and Physics, 2020, 20, 15427-15442
29. Guimar?es, P.; Ye, J.; Batista, C.; Barbosa, R.; Ribeiro, I.; Medeiros, A.; Zhao, T.; Hwang, W.-C.; Hung H.-M.; Souza, R.; Martin, S.T., Vertical profiles of atmospheric species concentrations and nighttime boundary layer structure in the dry season over an urban environment in the central Amazon collected by an unmanned aerial vehicle. Atmosphere, 2020, 11, 1371
30. Wang, J.; Ye, J.; Liu, D.; Wu, Y.; Zhao, J.; Xu, W.; Xie, C.; Shen, F.; Zhang, J.; Ohno, P.E.; Qin, Y.; Zhao, X.; Martin, S.T.; Lee, A.K.Y.; Fu, P.; Jacob, D.J.; Zhang, Q.; Sun, Y.; Chen, M.; Ge, X., Characterization of submicron organic particles in Beijing during summertime: comparison between SP-AMS and HR-AMS. Atmospheric Chemistry and Physics, 2020, 20, 14091-14102
31. Qin, Y.; Ye, J.; Ohno, P.E.; Lei, Y.; Wang, J.; Liu, P.; Thomson, R.; Martin, S.T., Synergistic uptake by acidic sulfate particles of gaseous mixtures of glyoxal and pinanediol. Environmental Science & Technology, 2020, 54, 11762-11770
32. Ma, Y.#; Ye, J.#; Xin, J.; Zhang, W.; Vilà-Guerau de Arellano, J.; Zhao, D.; Dai, L.; Wu, X.; Xia, X.; Tang, F.; Wand, Y.; Shen, P.; Lei, Y.; Martin, S.T., The stove, dome, and umbrella effects of atmospheric aerosol on the development of the planetary boundary layer in hazy regions. Geophysical Research Letters, 2020, 47, e2020GL087373
33. Wang, J.#; Li, J.#; Ye, J.#; Zhao, J.; Wu, Y.; Hu, J.; Liu, D.; Nie, D.; Shen, F.; Huang, X.; Huang, D.; Ji, D.; Sun, X.; Xu, W.; Guo, J.; Song, S.; Qin, Y.; Liu, P.; Liao, H.; Turner, J.R.; Martin, S.T.; Zhang, Q.; Chen, M.; Sun, Y.; Ge, X.; Jacob, D.J., Fast sulfate formation from oxidation of SO2 by NO2 and HONO observed in Beijing haze. Nature Communications, 2020, 11, 2844 Highly cited article
34. Ribeiro, I.O.; Santos, E.O.; Batista, C.E.; Fernandes, K.S.; Ye, J.; Medeiros, A.S.; Oliveira, R.L.; Sá, S.S.; Sousa, T.R.; Kayano, M.T.; Andreoli, R.V.; Machado, C.M.D.; Surratt, J.D.; Duvoisin Jr., S.; Martin, S.T.; Souza, R.A.F., Impact of biomass burning on a metropolitan area in the Amazon during the 2015 El Ni?o: The enhancement of carbon monoxide and levoglucosan concentrations. Environmental Pollution, 2020, 260, 114029
35. Wang, Y; Wang, Q.; Ye, J.; Li, L.; Zhou, J.; Ran, W.; Zhang, R.; Wu, Y.; Cao, J., Chemical composition and sources of submicron aerosols in winter at a regional site in Beijing-Tianjin-Hebei region: implication for the Joint Action Plan. Science of the Total Environment, 2020, 719, 137547
36. Liu, B.; Wu, C.; Ma, N.; Chen, Q.; Li, Y.; Ye, J.; Martin, S.T.; Li, Y.J., Vertical profiling of fine particulate matter and black carbon by using unmanned aerial vehicle in Macau, China. Science of the Total Environment, 2020, 709, 136109
37. Tian, J.; Wang, Q.; Han, Y.; Ye, J.; Wang, P.; Pongpiachan, S.; Ni, H.; Zhou, Y.; Wang, M.; Zhao, Y.; Cao, J., Contributions of aerosol composition and sources to particulate optical properties in a southern coastal city of China. Atmospheric Research, 2020, 235, 104744
38. Han, Y.; Gong, Z.; Ye, J.; Liu, P.; McKinney, K.A.; Martin, S.T., Quantifying the role of the relative-humidity dependent physical state of organic particulate matter on the uptake of semivolatile organic molecules. Environmental Science & Technology, 2019, 53, 13209-13218
39. Wang, Q.; Ye, J.; Wang, Y.; Zhang, T.; Ran, W.; Wu, Y.; Tian, J.; Li, L.; Zhou, Y.; Ho, S.S.H.; Dang, B.; Zhang, Q.; Zhang, R.; Chen, Y.; Zhu, C.; Cao, J., Winter brown carbon absorption from primary emissions and secondary formation at a regional background site in the north China plain. Environmental Science & Technology, 2019, 53, 12389-12397
40. Guimar?es, P.; Ye, J.; Batista, C.; Barbosa, R.; Ribeiro, I.; Medeiros, A.; Souza, R.; Martin, S.T., Vertical profiles of ozone concentration collected by an unmanned aerial vehicle and the mixing of the nighttime boundary layer over an Amazonian urban area. Atmosphere, 2019, 10, 599
41. Batista, C.E.#; Ye, J.*#; Ribeiro, I.O.; Guimar?es, P.C.; Medeiros, A.; Barbosa, R.G.; Oliveria, R.L.; Duvoisin Jr.S.; Jardin, K.J.; Gu, D.; Guenther, A.B.; McKinney, K.A.; Martins, L.D.; Souza, R.A.F.*; Martin, S.T.*, Intermediate-scale horizontal isoprene concentrations in the near-canopy forest atmosphere and implications for emission heterogeneity. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116, 19318-19323 Altmetric Top 5% High Attention, highlighted by Harvard News and other media outlets
42. Wang, S.; Zhou, S.; Tao, W.; Tsui, W.G.; Ye, J.; Yu, J.Z.; Murphy, J.G.; McNeil, V.F.; Abbatt, J.P.D.; Chan, A.W.H., Organic peroxides and sulfur dioxide in aerosol: source of particulate sulfate. Environmental Science & Technology, 2019, 53, 10695-10704
43. Wang, Q.; Han, Y.; Ye, J.; Liu, S.; Pongpiachan, S.; Zhang, N.; Han, Y.; Tian, J.; Wu, C.; Long, X.; Zhang, Q.; Zhang, W.; Zhao, Z.; Cao, J., High contribution of secondary brown carbon to aerosol light absorption in the southeastern margin of Tibetan Plateau. Geophysical Research Letters, 2019, 46, 4962-4970
44. Wang, Y.; Wang, Q.; Ye, J.; Yan, M.; Qin, Q.; Prév?t, A.; Cao, J., A Review of Aerosol Chemical Composition and Sources in Representative Regions of China during Wintertime. Atmosphere, 2019, 10, 277
45. McKinney, K.A.; Wang, D.; Ye, J.; de Fouchier, J.-B.; Batista, C.E.; Guimar?es, P.C.; Souza, R.A.F.; Alves, E.G.; Gu, D.; Guenther, A.B.; Martin, S.T., A sampler for atmospheric volatile organic compounds by copter unmanned aerial vehicles. Atmospheric Measurement Techniques, 2019, 12, 3123-3135. European Geosciences Union highlight article
46. Wang, Y.; Chen, J.; Wang, Q.; Qin, Q.; Ye, J.; Han, Y.; Li, L.; Zhen, W.; Zhi, Q.; Zhang, Y.; Cao, J., Increased secondary aerosol contribution and possible processing on polluted winter days in China. Environment International, 2019, 127, 78-84
47. Ye, J.; Van Rooy, P.; Adam, C. H.; Jeong, C-H; Urch B.; Cocker, D. R.; Evans, G. J.; Chan, A. W. H., Predicting secondary organic aerosol enhancement in the presence of atmospherically relevant organic particles. ACS Earth and Space Chemistry, 2018, 2, 1035-1046
48. Gong, Z.; Han, Y.; Liu, P.; Ye, J.; Keutsch, F. N.; McKinney, K.A.; Martin, S.T., Influence of particle physical state on the uptake of medium-sized organic molecules. Environmental Science & Technology, 2018, 52, 8381-8389
49. Ye, J.; Abbatt, J.P.D.; Chan, A.W.H., Novel pathway of SO2 oxidation in the atmosphere: reactions with monoterpene ozonolysis intermediates and secondary organic aerosol. Atmospheric Chemistry and Physics, 2018, 18, 5549-5565. European Geosciences Union highlight article
50. Wang, S.; Ye, J.; Soong, R.; Wu, B.; Yu, L.; Simpson, A.; Chan, A.W.H., Relationship between chemical composition and oxidative potential of secondary organic aerosol from polycyclic aromatic hydrocarbons. Atmospheric Chemistry and Physics, 2018, 18, 3987-4003
51. Ye, J.; Salehi, S.; North, M.L.; Portelli, A.M.; Chow, C-W.; Chan, A.W.H., Development of a novel simulation reactor for chronic exposure to atmospheric particulate matter. Scientific Reports, 2017, 7, 42317
52. Ye, J.; Gordon, C.A.; Chan, A.W.H., Enhancement in secondary organic aerosol formation in the presence of preexisting organic particle. Environmental Science & Technology, 2016, 50, 3572-3579
53. Ye, J.; Hatano, S.; Abe, M.; Kishi, R.; Murata, Y.; Nakano, M.; Adam, W., A puckered singlet cyclopentane-1, 3-diyl: detection of the third isomer in homolysis. Chemistry-A European Journal, 2016, 22, 2299-2306. Inside cover & hot paper
54. Gordon, C.A.; Ye, J.; Chan, A.W.H., Secondary organic aerosol formation enhanced by organic seeds of similar polarity at atmospherically relative humidity. STEM Fellowship Journal, 2015, 1, 6-10
55. Ye, J.; Fujiwara, Y.; Abe, M., Substituent effect on the energy barrier for σ-bond formation from π-single-bonded species, singlet 2, 2-dialkoxycyclopentane-1, 3-diyls. Beilstein Journal of Organic Chemistry, 2013, 9, 925-933
56. Abe, M.; Ye, J.; Mishima, M., The chemistry of localized singlet 1, 3-diradicals (biradicals): from putative intermediates to persistent species and unusual molecules with a π-single bonded character. Chemical Society Reviews, 2012, 41, 3808-3820