師資
●個(gè)人簡(jiǎn)介
王子龍，南方科技大學(xué)醫(yī)學(xué)院助理教授，博士生導(dǎo)師。本科畢業(yè)于蘭州大學(xué)生物學(xué)人才培養(yǎng)基地，2017年獲得蘭州大學(xué)-杜克大學(xué)聯(lián)合培養(yǎng)博士學(xué)位。隨后在杜克大學(xué)進(jìn)行博士后研究。王子龍長(zhǎng)期致力于痛覺(jué)和癢覺(jué)的分子細(xì)胞和神經(jīng)機(jī)制研究，以及鎮(zhèn)痛或止癢藥物的研發(fā)。以第一或通訊作者（含共同）在Science Translational Medicine、Brain、Neuron、Gastroenterology、Science Advances、Cell Discovery、J Med Chem.、Anesthesiology等國(guó)際期刊上發(fā)表SCI 論文19篇，以合作作者在Nature、Neuron（3篇）、Journal of clinical investigation、Nature communications（2篇）等國(guó)際期刊上發(fā)表SCI 論文30篇，總共發(fā)表SCI論文49篇；被引大于1900次，H-index為23。以主要發(fā)明人申請(qǐng)國(guó)家發(fā)明專(zhuān)利8件（已授權(quán)5件），美國(guó)專(zhuān)利2件，國(guó)際專(zhuān)利PCT 3件。
●教育背景
2007.09 – 2011.06，蘭州大學(xué)學(xué)士，生物科學(xué)
2011.09 – 2017.06，蘭州大學(xué)，博士，生物化學(xué)與分子生物學(xué)
2016.01 – 2017.01，杜克大學(xué)，聯(lián)合培養(yǎng)博士，神經(jīng)學(xué)系
●工作經(jīng)歷
2017.01 – 2017.10，杜克大學(xué)醫(yī)學(xué)院，訪問(wèn)學(xué)生，麻醉學(xué)系
2017.10 – 2021.01，杜克大學(xué)醫(yī)學(xué)院，博士后研究員，麻醉學(xué)系
2021.03 –至今， 南方科技大學(xué)醫(yī)學(xué)院，助理教授、博士生導(dǎo)師
●研究領(lǐng)域
痛覺(jué)和癢覺(jué)的分子細(xì)胞和神經(jīng)機(jī)制研究，以及鎮(zhèn)痛或止癢藥物的研發(fā)。
（1）阿片類(lèi)藥物鎮(zhèn)痛及其副作用的細(xì)胞分子以及神經(jīng)環(huán)路機(jī)制；
（2）鎮(zhèn)痛或止癢藥物研發(fā)。
（3）痛覺(jué)及癢覺(jué)的神經(jīng)機(jī)制及新靶點(diǎn)的發(fā)現(xiàn)；
（4）免疫-神經(jīng)相互作用；
（5）病理性疼痛的細(xì)胞分子機(jī)制研究及其臨床治療新藥新技術(shù)研發(fā)；
●獲獎(jiǎng)情況及榮譽(yù)
2015年 國(guó)家獎(jiǎng)學(xué)金
2017年 蘭州大學(xué)優(yōu)秀畢業(yè)生
雜志編委會(huì)成員
2017 - present 會(huì)員Member, 美國(guó)神經(jīng)科學(xué)學(xué)會(huì)Society for Neuroscience
審稿人：Trend in Neuroscience, British journal of pharmacology, Biomedicine & Pharmacotherapy, Acta Dermato-Venereologica，Experimental and Therapeutic Medicine, Journal of Zhejiang University-SCIENCE B, Neuronscience letters, Molecular pain, Acta Biochimica et Biophysica Sinica, Neuroscience Bulletin, nutrients, Journal of Nutritional Health & Food Science, Synapse等雜志審稿人。
近年代表文章
#co-first author, *corresponding author.
2024
49. Ximin Chi#*, Yiming Chen#, Yaning Li#, Lu Dai#, Yuanyuan Zhang, Yaping Shen, Yun Chen, Tianhao Shi, Haonan Yang, Zilong Wang*, Renhong Yan*. Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism. Science Advances, 2024, 10, eadl3685
48. Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahan, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, and Ru-Rong Ji*. Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. The Journal of Clinical Investigation, 2024, 134(9):e173537.
47. Songqiang Huang#, Wanting Dong#, Xiaoqian Lin, Kangtai Xu, Kun Li, Siping Xiong, Zilong Wang, Xiaowei Nie, Jin-Song Bian1. Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. Immunity, 2024, in press.
46. Leyan Shan#, Kangtai Xu#, Luyao Ji#, Qian Zeng#, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang *, and Zilong Wang * . Injured sensory neurons-derived Galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain, Behavior, and Immunity, 2024, 117: 80-99
2023
45. Yaning Li#, Yiming Chen#, Yuanyuan Zhang#, Yaping Shen#, Kangtai Xu, Yaqi Liu, Zilong Wang* and Renhong Yan*, Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1. Cell Discovery, 2023, 9:93
44. Fabiana C Dias#, Zilong Wang#, Garrett Scapellato and Yong Chen*, Silencing of TRPV4-expressing sensory neurons attenuates temporomandibular disorders pain. Molecular Pain, 2023, 19: 1–6.
43. K. Xu, Y. Wu, Z. Tian, Y. Xu, C. Wu*, and Z. Wang*, Microglial Cannabinoid CB(2) Receptors in Pain Modulation. Int J Mol Sci, 2023. 24(3).
42. L. Li, P. Li, J. Guo, Y. Wu, Q. Zeng, N. Li, X. Huang, Y. He, W. Ai, W. Sun, T. Liu, D. Xiong, L. Xiao, Y. Sun, Q. Zhou, H. Kuang, Z. Wang*, and C. Jiang*, Up-regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy-induced neuropathic pain. Br J Pharmacol, 2023. 180(13): p. 1730-1747.
2022
41. Qiaojuan Zhang, Fabiana Dias, Quan Fang, Gwendolyn Henry, Zilong Wang, Abbie Suttle, and Yong Chen, Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours. Acta dermato-venereologica, 2022. 102: p. adv00651-adv00651.
40. Vivian Lei, Chelsea Handfield, Jeffery T. Kwock, Stephen J. Kirchner, Min Jin Lee, Margaret Coates, Kaiyuan Wang, Qingjian Han, Zilong Wang, Jennifer G. Powers, Sarah Wolfe, David L. Corcoran, Brian Fanelli, Manoj Dadlani, Ru-Rong Ji, Jennifer Y. Zhang, and Amanda S. MacLeod, Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response. The Journal of investigative dermatology, 2022.
2021
39. Junli Zhao, Alexus Roberts, Zilong Wang, Justin Savage, and Ru-Rong Ji, Emerging Role of PD-1 in the Central Nervous System and Brain Diseases. Neuroscience Bulletin, 2021. 37(8): p. 1188-1202.
38. Michele Yeo, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Sharat Chandra, Andrey Bortsov, Maria Lioudyno, Qian Zeng, Peng Wang, Zilong Wang, Jorge Busciglio, Ru-Rong Ji, and Wolfgang Liedtke, Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission. Nature Communications, 2021. 12(1).
37. Zilong Wang* and Zhen-Zhong Xu, The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain. Neuroscience Bulletin, 2021. 37(7): p. 1079-1081.
36. Zilong Wang#*, Changyu Jiang#, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Junli Zhao, Yul Huh, and Ru-Rong Ji, Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. Brain, 2021. 144: p. 665-681.
35. Xin Luo, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R. Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, and Ru-Rong Ji, IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. Neuron, 2021. 109(17): p. 2691-+.
34. Christopher R. Donnelly, Changyu Jiang, Amanda S. Andriessen, Kaiyuan Wang, Zilong Wang, Huiping Ding, Junli Zhao, Xin Luo, Michael S. Lee, Yu L. Lei, William Maixner, Mei-Chuan Ko, and Ru-Rong Ji, STING controls nociception via type I interferon signalling in sensory neurons. Nature, 2021. 591(7849): p. 275-+.
33. Yong Chen#, Zi-Long Wang#, Michele Yeo, Qiao-Juan Zhang, Ana E. Lopez-Romero, Hui-Ping Ding, Xin Zhang, Qian Zeng, Sara L. Morales-Lazaro, Carlene Moore, Ying-Ai Jin, Huang-He Yang, Johannes Morstein, Andrey Bortsov, Marcin Krawczyk, Frank Lammert, Manal Abdelmalek, Anna Mae Diehl, Piotr Milkiewicz, Andreas E. Kremer, Jennifer Y. Zhang, Andrea Nackley, Tony E. Reeves, Mei-Chuan Ko, Ru-Rong Ji, Tamara Rosenbaum, and Wolfgang Liedtke, Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. Gastroenterology, 2021. 161(1): p. 301-+.
32. Sangsu Bang, Christopher R. Donnelly, Xin Luo, Maria Toro-Moreno, Xueshu Tao, Zilong Wang, Sharat Chandra, Andrey V. Bortsov, Emily R. Derbyshire, and Ru-Rong Ji, Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. Nature Communications, 2021. 12(1).
2020
31. Biao Xu, Mengna Zhang, Xuerui Shi, Run Zhang, Dan Chen, Yong Chen, Zilong Wang, Yu Qiu, Ting Zhang, Kangtai Xu, Xiaoyu Zhang, Wolfgang Liedtke, Rui Wang, and Quan Fang, The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via mu- and kappa-opioid receptors. British Journal of Pharmacology, 2020. 177(1): p. 93-109.
30. Zilong Wang, Biao Xu, Changyu Jiang, Ting Zhang, Mengna Zhang, Ning Li, Qinqin Zhang, Kangtai Xu, Dan Chen, Jian Xiao, and Quan Fang, Spinal DN-9, a Peptidic Multifunctional Opioid/Neuropeptide FF Agonist Produced Potent Nontolerance Forming Analgesia With Limited Side Effects. Journal of Pain, 2020. 21(3-4): p. 477-493.
29. Zilong Wang#, Changyu Jiang#, Qianru He, Megumi Matsuda, Qingjian Han, Kaiyuan Wang, Sangsu Bang, Huiping Ding, Mei-Chuan Ko, and Ru-Rong Ji, Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. Science Translational Medicine, 2020. 12(531).
28. Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L. Hsu, Qianru He, Mario J. Borgnia, Ru-Rong Ji, and Seok-Yong Lee, Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 2020. 105(5): p. 882-+.
27. Changyu Jiang, Zilong Wang, Christopher R. Donnelly, Kaiyuan Wang, Amanda S. Andriessen, Xueshu Tao, Megumi Matsuda, Junli Zhao, and Ru-Rong Ji, PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia. Iscience, 2020. 23(10).
26. Sharat Chandra#, Zilong Wang#, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov, Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. Anesthesiology, 2020. 133(3): p. 611-627.
2019
25. Ting Zhang, Zhenglan Han, Xuerui Shi, Weidong Zhao, Zilong Wang, Run Zhang, Biao Xu, Mengna Zhang, Qinqin Zhang, Jian Xiao, Hanwen Zhu, Ting Zheng, and Quan Fang, Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation. Bioorganic & Medicinal Chemistry, 2019. 27(4): p. 630-643.
24. Zilong Wang, Christopher R. Donnelly, and Ru-Rong Ji, Scratching after Stroking and Poking: A Spinal Circuit Underlying Mechanical Itch. Neuron, 2019. 103(6): p. 952-954.
2018
23. Chao Chen, Biao Xu, Xuerui Shi, Mengna Zhang, Qinqin Zhang, Ting Zhang, Weidong Zhao, Run Zhang, Zilong Wang, Ning Li, and Quan Fang, GpTx-1 and Ala(5), Phe(6), Leu(26), Arg(28) GpTx-1, two peptide Na(V)1.7 inhibitors: analgesic and tolerance properties at the spinal level. British Journal of Pharmacology, 2018. 175(20): p. 3911-3927.
22. Sangsu Bang, Ya-Kai Xie, Zhi-Jun Zhang, Zilong Wang, Zhen-Zhong Xu, and Ru-Rong Ji, GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. Journal of Clinical Investigation, 2018. 128(8): p. 3568-3582.
21. Ting Zhang, Nan Zhang, Run Zhang, Weidong Zhao, Yong Chen, Zilong Wang, Biao Xu, Mengna Zhang, Xuerui Shi, Qinqin Zhang, Yuanyuan Guo, Jian Xiao, Dan Chen, and Quan Fang, Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. Journal of Neuroinflammation, 2018. 15.
20. Qingjian Han, Di Liu, Marino Convertino, Zilong Wang, Changyu Jiang, Yong Ho Kim, Xin Luo, Xin Zhang, Andrea Nackley, Nikolay V. Dokholyan, and Ru-Rong Ji, miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus. Neuron, 2018. 99(3): p. 449-+.
2017
19. Ting Zheng, Ting Zhang, Run Zhang, Zi-Long Wang, Zheng-Lan Han, Ning Li, Xu-Hui Li, Meng-Na Zhang, Biao Xu, Xiong-Li Yang, Quan Fang, and Rui Wang, Pharmacological characterization of rat VD-hemopressin(alpha), an alpha-hemoglobin-derived peptide exhibiting cannabinoid agonist-like effects in mice. Neuropeptides, 2017. 63: p. 83-90.
18. Run Zhang, Biao Xu, Meng-na Zhang, Ting Zhang, Zi-long Wang, Geng Zhao, Guang-hai Zhao, Ning Li, Quan Fang, and Rui Wang, Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model. European Journal of Pharmacology, 2017. 813: p. 122-129.
2016
17. Hong-ping Yu, Nan Zhang, Ting Zhang, Zi-long Wang, Ning Li, Hong-hai Tang, Run Zhang, Meng-na Zhang, Biao Xu, Quan Fang, and Rui Wang, Activation of NPFF2 receptor stimulates neurite outgrowth in Neuro 2A cells through activation of ERK signaling pathway. Peptides, 2016. 86: p. 24-32.
16. Zi-Long Wang, Jia-Xin Pan, Jing-Jing Song, Hong-Hai Tang, Hong-Ping Yu, Xu-Hui Li, Ning Li, Ting Zhang, Run Zhang, Meng-Na Zhang, Biao Xu, Quan Fang, and Rui Wang, Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities. Journal of Medicinal Chemistry, 2016. 59(22): p. 10198-10208.
15. Zi-long Wang#, Ning Li#, Pei Wang, Hong-hai Tang, Zheng-lan Han, Jing-jing Song, Xu-hui Li, Hong-ping Yu, Ting Zhang, Run Zhang, Biao Xu, Meng-na Zhang, Quan Fang, and Rui Wang, Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance. Neuropharmacology, 2016. 108: p. 364-372.
14. X. H. Li, M. L. Lin, Z. L. Wang, P. Wang, H. H. Tang, Y. Y. Lin, N. Li, Q. Fang, and R. Wang, Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice. Neurogastroenterology and Motility, 2016. 28(6): p. 891-899.
13. Ning Li, Zheng-lan Han, Zi-long Wang, Yan-hong Xing, Yu-long Sun, Xu-hui Li, Jing-jing Song, Ting Zhang, Run Zhang, Meng-na Zhang, Biao Xu, Quan Fang, and Rui Wang, BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice. British Journal of Pharmacology, 2016. 173(11): p. 1864-1880.
12. Yong Chen, Quan Fang, Zilong Wang, Jennifer Y. Zhang, Amanda S. MacLeod, Russell P. Hall, and Wolfgang B. Liedtke, Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. Journal of Biological Chemistry, 2016. 291(19): p. 10252-10262.
2015
11. Jia-Xin Pan#, Zi-Long Wang#, Ning Li, Nan Zhang, Pei Wang, Hong-Hai Tang, Ting Zhang, Hong-Ping Yu, Run Zhang, Ting Zheng, Quan Fang, and Rui Wang, Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice. European Journal of Pharmacology, 2015. 767: p. 119-125.
10. Zheng-lan Han, Zi-long Wang, Xu-hui Li, Ning Li, Jia-xin Pan, Ting Zheng, Quan Fang, and Rui Wang, Neuropeptide VF Enhances Cannabinoid Agonist WIN55,212-2-Induced Antinociception in Mice. Anesthesia and Analgesia, 2015. 121(5): p. 1360-1368.
2014
9. Wangsheng Sun, Liang Hong, Gongming Zhu, Zilong Wang, Xiaojin Wei, Jingman Ni, and Rui Wang, An Organocatalytic Michael-Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters. Organic Letters, 2014. 16(2): p. 544-547.
8. Jia-Xin Pan, Zi-Long Wang, Ning Li, Zheng-Lan Han, Xu-Hui Li, Hong-Hai Tang, Pei Wang, Ting Zheng, Quan Fang, and Rui Wang, Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(alpha) and WIN55,212-2 at the supraspinal level in mice. Neuroscience Letters, 2014. 578: p. 187-191.
7. Xu-hui Li, Ning Li, Zi-long Wang, Jia-xin Pan, Zheng-lan Han, Xue-mei Chang, Hong-hai Tang, Pei Wang, Rui Wang, and Quan Fang, The hypotensive effect of intrathecally injected (m) VD-hemopressin(alpha) in urethane-anesthetized rats. Peptides, 2014. 56: p. 45-51.
6. Zheng-lan Han#, Quan Fang#, Zi-long Wang, Xu-hui Li, Ning Li, Xue-mei Chang, Jia-xin Pan, Hong-zhu Tang, and Rui Wang, Antinociceptive Effects of Central Administration of the Endogenous Cannabinoid Receptor Type 1 Agonist VDPVNFKLLSH-OH (m)VD-hemopressin(alpha) , an N-Terminally Extended Hemopressin Peptide. Journal of Pharmacology and Experimental Therapeutics, 2014. 348(2): p. 316-323.
5. Zi-long Wang#, Quan Fang#, Zheng-lan Han, Jia-xin Pan, Xu-hui Li, Ning Li, Hong-hai Tang, Pei Wang, Ting Zheng, Xue-mei Chang, and Rui Wang, Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice. Plos One, 2014. 9(8).
2013
4. Zheng-lan Han, Zi-long Wang, Hong-zhu Tang, Ning Li, Quan Fang, Xu-hui Li, Xiong-li Yang, Xiao-yu Zhang, and Rui Wang, Neuropeptide FF attenuates the acquisition and the expression of conditioned place aversion to endomorphin-2 in mice. Behavioural Brain Research, 2013. 248: p. 51-56.
3. Xin Liu, Yuan Wang, Yanhong Xing, Jing Yu, Hong Ji, Ming Kai, Zilong Wang, Dan Wang, Yixin Zhang, Depeng Zhao, and Rui Wang, Design, Synthesis, and Pharmacological Characterization of Novel Endomorphin-1 Analogues as Extremely Potent mu-Opioid Agonists. Journal of Medicinal Chemistry, 2013. 56(7): p. 3102-3114.
2012
2. Ning Li, Zheng-lan Han, Quan Fang, Zi-long Wang, Hong-zhu Tang, Hui Ren, and Rui Wang, Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behavioural Brain Research, 2012. 233(2): p. 428-433.
1. Quan Fang, Zheng-Lan Han, Ning Li, Zi-Long Wang, Ning He, and Rui Wang, Effects of neuropeptide FF system on CB1 and CB2 receptors mediated antinociception in mice. Neuropharmacology, 2012. 62(2): p. 855-864.
· 專(zhuān)利成果
1. 王 銳，方 泉，韓政嵐，王子龍，李寧；“基于阿片肽Biphalin和神經(jīng)肽FF的嵌合肽及其合成和應(yīng)用”，國(guó)家發(fā)明專(zhuān)利，授權(quán)專(zhuān)利號(hào)：ZL201210098832.2，授權(quán)日期：2014年5月21日。已申請(qǐng)國(guó)際專(zhuān)利，PCT/CN2013/070611
2. 王 銳，方 泉，韓政嵐，王子龍，李寧，李旭輝；“內(nèi)源性大麻肽類(lèi)激動(dòng)劑(m)VD-Hpα在制備鎮(zhèn)痛藥物中的應(yīng)用”，國(guó)家發(fā)明專(zhuān)利，授權(quán)專(zhuān)利號(hào)：ZL201310087565.3，授權(quán)日期：2015年4月22日。
3. 王 銳，方 泉，李 寧，韓政嵐，王子龍；“基于內(nèi)嗎啡肽2和NPFF受體拮抗劑RF9的分叉型雜交肽及其合成方法和應(yīng)用”，國(guó)家發(fā)明專(zhuān)利，專(zhuān)利號(hào)： ZL201510123629.X，授權(quán)日期：2017年11月28日
4. 王 銳，方 泉，王 沛，張 婷，王子龍，李寧；“基于內(nèi)嗎啡肽2或Biphalin的棕櫚酰化修飾的阿片肽類(lèi)似物及其合成和應(yīng)用”， 國(guó)家發(fā)明專(zhuān)利，授權(quán)專(zhuān)利號(hào)： ZL201510619850.4，授權(quán)日期：2018年5月1日
5. 王 銳，方 泉，王子龍；“一類(lèi)阿片和神經(jīng)肽FF受體的多靶點(diǎn)肽類(lèi)分子及其制備和應(yīng)用”，國(guó)家發(fā)明專(zhuān)利，授權(quán)專(zhuān)利號(hào)： ZL201610252648.7，授權(quán)日期：2019年5月24日
6. 王 銳，方 泉，王子龍；“一種阿片和神經(jīng)肽FF受體的多靶點(diǎn)肽類(lèi)分子及其制備和應(yīng)用”，國(guó)家發(fā)明專(zhuān)利，專(zhuān)利申請(qǐng)?zhí)枺?01910194352.8，申請(qǐng)日期：2016年4月21日
7. 王 銳，方 泉，王子龍；“一類(lèi)阿片和神經(jīng)肽FF受體的多靶點(diǎn)肽類(lèi)分子及其制備和應(yīng)用”，國(guó)家發(fā)明專(zhuān)利，專(zhuān)利申請(qǐng)?zhí)枺?201910195051.7，申請(qǐng)日期：2016年4月21日
8. 王 銳，方 泉，韓政嵐，王子龍，李寧；“基于阿片肽Biphalin和神經(jīng)肽FF的嵌合肽及其合成和應(yīng)用”，國(guó)際專(zhuān)利，PCT/CN2013/070611，申請(qǐng)日期：2013年1月17日
9. 王 銳，方 泉，王子龍，許彪；“一類(lèi)阿片和神經(jīng)肽FF受體的多靶點(diǎn)肽類(lèi)分子及其制備方法和應(yīng)用”，國(guó)際專(zhuān)利，PCT/CN2017/080350，申請(qǐng)日期：2017年4月13日
10. Rui Wang, Quan Fang, Zilong Wang, Biao Xu. 專(zhuān)利名稱(chēng)（中文）：一類(lèi)阿片和神經(jīng)肽FF受體的多靶點(diǎn)肽類(lèi)分子及其制備方法和應(yīng)用；專(zhuān)利名稱(chēng)（英文）MULTI-TARGET PEPTIDE MOLECULES OF OPIOID AND NEUROPEPTIDE FF RECEPTOR, PREPARATION FOR MOLECULES, AND APPLICATIONS THEREOF；申請(qǐng)?zhí)枺║S Appl. No.）：US 16/343,873；國(guó)際申請(qǐng)日：2017.4.13；進(jìn)入美國(guó)日期：2019.4.22 （申請(qǐng)美國(guó)專(zhuān)利1件）
11. Ru-rong Ji, Gang Chen, Zilong Wang, Changyu Jiang, Kaiyuan Wang. METHODS AND KITS FOR TREATING PAIN. PCT. Application number: PCT / US2018 / 032475
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●Web of Science Researcher ID: AAB-4143-2019
●ORCID: 0000-0001-7473-0354
●ResearchGate: https://www.researchgate.net/profile/Zilong_Wang24/contributions
●Google Scholar: https://scholar.google.com/citations?user=Umxmd0gAAAAJ&hl=zh-CN