個(gè)人簡(jiǎn)介：
現(xiàn)任南方科技大學(xué)生命科學(xué)學(xué)院教授。本科畢業(yè)于山東大學(xué)，博士畢業(yè)于加拿大麥克馬斯特大學(xué)，在哈佛大學(xué)醫(yī)學(xué)院進(jìn)行博士后研究并獲得加拿大班庭獎(jiǎng)學(xué)金。在加拿大卡爾加里大學(xué)先后任助理教授至終身正教授。曾獲得加拿大創(chuàng)新基金、健康研究基金和自然科學(xué)基金等總額300萬加元的資助，現(xiàn)主持國家自然基金重點(diǎn)項(xiàng)目和重點(diǎn)研發(fā)課題等多個(gè)項(xiàng)目。
（https://orcid.org/0000-0003-3557-1850）
研究領(lǐng)域：
研究方向包括病原細(xì)菌與宿主的相互作用、抗生素耐藥性機(jī)理、和蛋白質(zhì)VI型分泌系統(tǒng)（T6SS）的分泌機(jī)理、功能及菌群的調(diào)控等。
工作經(jīng)歷：
2011-2013 Harvard Medical School, Postdoctoral Fellow
2013-2021 University of Calgary, Assistant to Full Professor
2017-2021 Shanghai Jiao Tong University, Principle Investigator
學(xué)習(xí)經(jīng)歷：
1999-2003 Shandong University, BSc
2004-2010 McMaster University, PhD
所獲榮譽(yù)：
2012-2014 Banting Fellow
2014-2024 Canada Research Chair in Molecular Ecology of Waterborne Microbes
代表文章：
(1) Hersch, S. J.; Lam, L.; Dong, T. G. Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase. mBio 2021, 12 (4), 2021.05.11.443660. https://doi.org/10.1128/mBio.01115-21.
(2) Manera, K.; Caro, F.; Li, H.; Pei, T.-T.; Hersch, S. J.; Mekalanos, J. J.; Dong, T. G. Sensing of Intracellular Hcp Levels Controls T6SS Expression in Vibrio Cholerae. Proc. Natl. Acad. Sci. 2021, 118 (25), e2104813118. https://doi.org/10.1073/pnas.2104813118.
(3) Hersch, S. J.; Watanabe, N.; Stietz, M. S.; Manera, K.; Kamal, F.; Burkinshaw, B.; Lam, L.; Pun, A.; Li, M.; Savchenko, A.; Dong, T. G. Envelope Stress Responses Defend against Type Six Secretion System Attacks Independently of Immunity Proteins. Nat. Microbiol. 2020, 5 (5), 706–714. https://doi.org/10.1038/s41564-020-0672-6.
(4) Pei, T.-T.; Li, H.; Liang, X.; Wang, Z.-H.; Liu, G.; Wu, L.-L.; Kim, H.; Xie, Z.; Yu, M.; Lin, S.; Xu, P.; Dong, T. G. Intramolecular Chaperone-Mediated Secretion of an Rhs Effector Toxin by a Type VI Secretion System. Nat. Commun. 2020, 11 (1), 1865. https://doi.org/10.1038/s41467-020-15774-z.
(5) Stietz, M. S.; Liang, X.; Li, H.; Zhang, X.; Dong, T. G. TssA–TssM–TagA Interaction Modulates Type VI Secretion System Sheath-Tube Assembly in Vibrio Cholerae. Nat. Commun. 2020, 11 (1), 5065. https://doi.org/10.1038/s41467-020-18807-9.
(6) Liang, X.; Kamal, F.; Pei, T.-T.; Xu, P.; Mekalanos, J. J.; Dong, T. G. An Onboard Checking Mechanism Ensures Effector Delivery of the Type VI Secretion System in Vibrio Cholerae. Proc. Natl. Acad. Sci. 2019, 116 (46), 23292–23298. https://doi.org/10.1073/pnas.1914202116.
(7) Burkinshaw, B. J.; Liang, X.; Wong, M.; Le, A. N. H.; Lam, L.; Dong, T. G. A Type VI Secretion System Effector Delivery Mechanism Dependent on PAAR and a Chaperone–Co-Chaperone Complex. Nat. Microbiol. 2018, 3 (5), 632–640. https://doi.org/10.1038/s41564-018-0144-4.
(8) Liang, X.; Moore, R.; Wilton, M.; Wong, M. J. Q.; Lam, L.; Dong, T. G. Identification of Divergent Type VI Secretion Effectors Using a Conserved Chaperone Domain. Proc. Natl. Acad. Sci. 2015, 112 (29), 9106–9111. https://doi.org/10.1073/pnas.1505317112.
