師資
任歡，南方科技大學(xué)醫(yī)學(xué)院教學(xué)教授，博士生導(dǎo)師。1991年獲醫(yī)學(xué)學(xué)士學(xué)位，1997年獲免疫學(xué)碩士學(xué)位。2001-2005年在英國(guó)利物浦大學(xué)醫(yī)學(xué)院工作并獲得博士學(xué)位，2009年哈爾濱醫(yī)科大學(xué)藥學(xué)博士后出站。2006-2018年在哈爾濱醫(yī)科大學(xué)擔(dān)任免疫學(xué)教研室主任、教授、博士生導(dǎo)師，省級(jí)領(lǐng)軍人才梯隊(duì)學(xué)術(shù)帶頭人。目前擔(dān)任中國(guó)免疫學(xué)會(huì)理事，中華醫(yī)學(xué)核心期刊《國(guó)際免疫學(xué)》副主編；國(guó)家自然基金、波蘭國(guó)家自然基金、教育部學(xué)位點(diǎn)論文評(píng)審專家。多年來(lái)一直從事醫(yī)學(xué)免疫學(xué)教學(xué)和科研工作。主講本科生與研究生課程《醫(yī)學(xué)免疫學(xué)》、《腫瘤免疫學(xué)》、《臨床免疫及診斷》《分子免疫學(xué)及進(jìn)展》、《Medical Immunology》等。作為主編、副主編或參編醫(yī)學(xué)免疫學(xué)教材和參考書十余部；主編或參編中英文學(xué)術(shù)專著9部。主持完成多項(xiàng)國(guó)家自然基金面上項(xiàng)目以及重大研究計(jì)劃培育項(xiàng)目等科研課題，獲得教育部提名科技進(jìn)步一等獎(jiǎng)、黑龍江省科技進(jìn)步二等獎(jiǎng)、世界衛(wèi)生組織獎(jiǎng)學(xué)金等獎(jiǎng)勵(lì)。任歡課題組采用生物醫(yī)學(xué)實(shí)驗(yàn)、生物信息學(xué)、臨床醫(yī)學(xué)、生物物理及數(shù)學(xué)模型等多學(xué)科研究方法，以腫瘤生物免疫與靶向治療基礎(chǔ)與應(yīng)用研究為主要方向。重點(diǎn)關(guān)注惡性腫瘤多分子靶標(biāo)診斷、腫瘤免疫微環(huán)境在診療中的作用，以及建立體外藥物篩選檢測(cè)平臺(tái)和腫瘤疫苗研發(fā)等。近年來(lái)在國(guó)際學(xué)術(shù)期刊包括 Nuclear Acid Research, Neuro-oncology, Cell Death & Differentiation, Mol Cancer Ther, Oncotarget, BMC Immuology 等發(fā)表論文60多篇。
主要工作經(jīng)歷:
1991.06-1994.09 哈爾濱市第一醫(yī)院神經(jīng)內(nèi)科 臨床護(hù)師
1997.06-2019.01 哈爾濱醫(yī)科大學(xué) 基礎(chǔ)醫(yī)學(xué)院免疫學(xué)教研室講師、副教授（2002年）、教授（2005年）
2001.04-2001.10 英國(guó)牛津布魯克斯學(xué)院細(xì)胞生物學(xué)系，世界衛(wèi)生組織訪問(wèn)學(xué)者
2001.10-2004.11 英國(guó)利物浦大學(xué)醫(yī)學(xué)院神經(jīng)學(xué)系 兼職研究員
2006.06-2019.01 哈爾濱醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院免疫學(xué)教研室主任；黑龍江省級(jí)領(lǐng)軍人才梯隊(duì)（免疫學(xué)）帶頭人（2008-2019）
2007.12-2009.12 哈爾濱醫(yī)科大學(xué) 藥理學(xué)博士后工作流動(dòng)站 博士后（楊寶峰院士）
2015.04-2015.10 美國(guó)加州大學(xué)圣地亞哥分校 訪問(wèn)教授
2019.01-至今 南方科技大學(xué) 醫(yī)學(xué)院 教學(xué)教授 博士生導(dǎo)師
教育背景：
1986.09-1991.06 中國(guó)醫(yī)科大學(xué) 醫(yī)學(xué)士學(xué)位
1994.09-1997.06 哈爾濱醫(yī)科大學(xué) 免疫學(xué)碩士學(xué)位 （田景先教授）
2000.09-2003.06 哈爾濱醫(yī)科大學(xué) 免疫學(xué)博士學(xué)位 （李殿俊教授）
2001.09-2005.12 英國(guó)利物浦大學(xué)醫(yī)學(xué)院 神經(jīng)學(xué)博士學(xué)位 （Dr. Nikolai Rainov）
主要學(xué)術(shù)兼職:
中國(guó)免疫學(xué)會(huì) 第六屆、第七屆理事
黑龍江省生物信息學(xué)會(huì) 監(jiān)事（2019-）
《國(guó)際免疫學(xué)雜志》 第七屆、第八屆副總編輯
《哈爾濱醫(yī)科大學(xué)學(xué)報(bào)》 編委（2008-2019）
《中國(guó)研究型雜志》編委（2020-）
Frontiers in Immunology, review editor (2020-)
《腫瘤防治研究》 編委
全國(guó)高校教師教學(xué)創(chuàng)新大賽廣東省賽區(qū)網(wǎng)絡(luò)評(píng)委（2020）
國(guó)家自然科學(xué)基金委員會(huì) 評(píng)審專家（2008-）
國(guó)家教育部學(xué)位與研究生教育評(píng)估中心 評(píng)審專家（2016-）
波蘭國(guó)家自然科學(xué)基金評(píng)審專家（2016-）
Neuro-oncology, PloS One, Cancer letters, BMC cancer, etc. 審稿專家
主持科研項(xiàng)目（2010年-）及主要科研獎(jiǎng)勵(lì):
科研項(xiàng)目：
1. 巨噬細(xì)胞M1/M2型極性轉(zhuǎn)化對(duì)肝轉(zhuǎn)移瘤微循環(huán)構(gòu)建的作用與機(jī)制；國(guó)家自然科學(xué)基金 面上項(xiàng)目（NSFC-81871993）2019-2022
2. 抑癌基因缺失下EGFR活化通過(guò)調(diào)控微環(huán)境適變介導(dǎo)膠質(zhì)母細(xì)胞瘤惡性發(fā)展，國(guó)家自然科學(xué)基金面上項(xiàng)目（NSFC-81472367）2015-2018
3. EGFR 過(guò)表達(dá)協(xié)同PTEN 缺失介導(dǎo)的免疫炎性網(wǎng)絡(luò)促進(jìn)膠質(zhì)母細(xì)胞瘤惡性進(jìn)展的分子機(jī)制，國(guó)家自然科學(xué)基金重大研究計(jì)劃培育計(jì)劃（NSFC-91229112）2013-2015
4. 解析GBM 基于EGFR/PI3K 信號(hào)通路多模式靶向治療靶標(biāo)的研究，國(guó)家自然科學(xué)基金 面上項(xiàng)目（NSFC-30227738）2008-2010
5. 惡性腦腫瘤分子靶標(biāo)的確立及分子機(jī)制研究——惡性腦膠質(zhì)瘤分子亞型分類與靶向治療的基礎(chǔ)與臨床應(yīng)用研究，黑龍江省自然科學(xué)基金 重點(diǎn)項(xiàng)目（ZD200804-01）2009-2011
6. 基于EGFR/PI3K信號(hào)轉(zhuǎn)導(dǎo)通路惡性膠質(zhì)母細(xì)胞瘤靶向治療分子靶標(biāo)的研究，教育部科技發(fā)展中心高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金（20092307110006）2009-2011
7. 實(shí)驗(yàn)性自身免疫性葡萄膜視網(wǎng)膜炎（EAU）恢復(fù)期神經(jīng)組織-免疫細(xì)胞交互作用及其相關(guān)機(jī)制，教育部“春暉計(jì)劃”（ Z2010003）2011-2012
8. 惡性腦膠質(zhì)瘤基于EGFR/PI3K信號(hào)轉(zhuǎn)導(dǎo)通路分子亞型分類的研究，中國(guó)博士后 特別資助（200902417）2007-2010
科研獎(jiǎng)勵(lì)：
1. 腫瘤生物治療的基礎(chǔ)與應(yīng)用系列性研究。2006年教育部提名國(guó)家科技進(jìn)步一等獎(jiǎng)（自然科學(xué)類，第三）
2. 惡性腦膠質(zhì)瘤細(xì)胞PDGFR/EGFR信號(hào)轉(zhuǎn)導(dǎo)通路上抗腫瘤靶點(diǎn)的作用及相互作用。哈爾濱市科技進(jìn)步二等獎(jiǎng)（2010年第一）、黑龍江省科技進(jìn)步二等獎(jiǎng)（2011年第一）
3. CIK體外增殖及體內(nèi)外抗腫瘤活性的實(shí)驗(yàn)研究?！吨袊?guó)腫瘤生物治療》雜志創(chuàng)刊20周年優(yōu)秀論文一等獎(jiǎng)（2015年 第一作者）
4. CD11bintF4/80hi腫瘤相關(guān)巨噬細(xì)胞在小鼠肝轉(zhuǎn)移瘤內(nèi)分化及功能解析。2020級(jí)碩士研究生譙婷獲得南方科技大學(xué)校優(yōu)秀學(xué)位論文（2023碩士生導(dǎo)師）
已發(fā)表科研學(xué)術(shù)論文（按年代順序排列）*通訊作者；代表作
1) Qiao T, Huan Ren*. Targeting against highly plastic macrophage within tumor microenvironment reveals combinational targets at tumor transitions in mouse colorectal liver metastases. Gut 2023; 72 (Suppl 1): A44
2) Wang TT, Wei LY, Meng SH, Song WC, Chen YL, Li H, Zhao QQ, Jiang ZY, Liu DZ, Ren H*, Hong XP*. Coordinated priming of NKG2D pathway by IL-15 enhanced functional properties of cytotoxic CD4+CD28- T cells expanded in Systemic Lupus Erythematosus. Inflammation 2023; DOI: 10.1007/s10753-023-01860-z
3) Zhang XH, Wang GY, Gong YJ, Zhao LL, Song P, Zhang H, Zhang YR, Ju HY, Wang XY, Wang B, Ren H*, Zhu X*, Dong YC*. IGFBP3 induced by TGF-b/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma. iScience 2023; 26(5):106639
4) Qiao T, Yang WL, He XC, Song P, Chen X, Liu RJ, Xiao J, Li MQ, Gao YD, Chen GA, Lu Y, Zhang J*, Leng J*, Ren H*. Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis. Cell Death Dis. 2023; 14(2):117
5) Zhang XH, Zhao LL, Zhang H, Zhang YR, Ju HY, Wang XY, Ren H*, Zhua X*, Dong YC*. The immunosuppressive microenvironment and immunotherapy in human glioblastoma. Front Immunol. 2022; 13: 1003651. doi: 10.3389/fimmu.2022.1003651
6) Chun Yang, Jianhong Lin, Hongyan Liang, Li Xue, Ariel Kwart, Meng Jiang, Jianjun Zhao, Huan Ren*, Xiaofeng Jiang* and Nikhil C Munshi*. CD44 v5 domain inhibition represses the polarization of Th2 cells by interfering with the IL-4/IL-4R signaling pathway. Immunol Cell Biol. 2022; 100(1):21-32. Doi:10.1111/imcb.12491.
7) Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, Lu F, Liu N, Yu M, Peng S, Wang Y, Zhao D, Zhao Y, Ren H, Cheng Z, Dong S, Lu F, Zhang W. Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice. Am J Physiol Endocrinol Metab. 2019;317(2):E284-E297
8) Sun Q, Pei C, Li Q, Dong T, Dong Y, Xing W, Zhou P, Gong Y, Zhen Z, Gao Y, Xiao Y, Su J, Ren H*. Up-regulation of MSH6 is associated with temozolomide resistance in human glioblastoma. Biochem Biophys Res Commun. 2018; 496 (4): 1040-1046.
9) Sun CH, Zou MY, Li L, Li DX, Ma YJ, Xia W, Wu LJ*, Ren H* Association study between inwardly rectifying potassium channels 2.1 and 4.1 and autism spectrum disorders. Life Sciences 2018; 213: 183
10) Jiao H, Ren H* The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain–Barré syndrome Drug Des Devel Ther 2018 6;12: 3817
11) Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W. Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice. J Mol Med (Berl). 2018;96(3-4):281-299
12) Teng YQ, DongYC, Liu ZY, Zou Y, Xie H，Zhao Y，Su J，Cao FL, Jin H*, Ren H*. DNA methylation-mediated caspase-8 down-regulation is highly relevant to anti-apoptosis activity and human malignant glioma grade. Int J Mol Med 2017; 39: 725-733
13) He X, Ren H*. Non-inflammasome forming NLRC3 suppresses tumorigenesis in the gut. J Xiangya Med 2017; 2: 64 (Editorial invited)
14) Xing WJ, Xiao Y, Lu XL, Li X*, Karin M*, Ren H*. GFI1 down-regulation promotes inflammation linked-metastasis of colorectal cancer. Cell Death & Differentiation 2017; 24 (5): 729-743
15) Lijie Sun, Yan Li, Xiuzhi Jia, Qi Wang, Weihua Zhang, Jingtao Wang, Hongwei Xu, Lihua Wang*, Dekai Zhang* and Huan Ren* Neuroprotection by IFN-g via astrocyte-secreted IL-6 in acute neuroinflammation. Oncotarget 2017; 8(25):40065-40078
16) Junwei Han , Siyao Liu , Zeguo Sun , Yunpeng Zhang , Fan Zhang , Chunlong Zhang , Desi Shang , Haixiu Yang , Fei Su , Yanjun Xu , Chunquan Li , Huan Ren* and Xia Li*. LncRNAs2Pathways: Identifying the pathways influenced by a set of interested lncRNAs based on global network propagation method. Scientific Reports 2017; 7: 46566
17) Liu ZY, Han L, Dong YC, Tan YL, Li YS, Zhao ML, Xie H, Ju HY, Wang H, Zhao Y, Zheng QF, Wang QX, Su J, Fang C, Fu SB, Jiang T, Liu JR, Li X*, Kang CS*, Ren H*. EGFRvIII/integrin β3 interactions in hypoxic and vitronectin-enriching microenvironment promote GBM progression and metastasis. Oncotarget 2016 Jan 26; 7(4):4680-94.
18) Xie H, Yang JF, Xing WJ, Dong YC, Ren H*. Nuclear EGFRvIII Resists Hypoxic Microenvironment Induced Apoptosis via Recruiting ERK1/2 Nuclear Translocation. Biochem Biophys Res Commun. 2016; 5; 470 (2):466-72.
19) Ju H, Xing W, Yang J, Zheng Y, Jia X, Zhang B, Ren H*. An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model. BMC Immunol. 2016; 17 (1): 31
20) Liu CD, Wang Q, Zong DK, Pei SC, Yan Y, Yan ML, Sun LL, Hao YY, Mao M, Xing WJ, Ren H, Ai J. Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion. Neurobiol Aging. 2016;45:76-87.
21) Tian L, Li L, Xing W, Li R, Pei C, Dong X, Fu Y, Gu C, Guo X, Jia Y, Wang G, Wang J, Li B, Ren H*, Xu H*. IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition. Scientific Reports 2015 Jul 23; 5: 12357.
22) Yang J, Xu Z, Sui M, Han J, Sun L, Jia X, Zhang H, Han C, Jin X, Gao F, Liu Y, Li Y, Cao J, Ling H, Zhang F*, Ren H*. Co-Positivity for Anti-dsDNA, -Nucleosome and -Histone Antibodies in Lupus Nephritis Is Indicative of High Serum Levels and Severe Nephropathy. PLoS One. 2015 Oct 14; 10 (10): e0140441
23) Dong H, Tian L, Li R, Pei C, Fu Y, Dong X, Xia F, Wang C, Li W, Guo X, Gu C, Li B, Liu A, Ren H, Wang C, Xu H. IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy. Oncogene. 2015 Oct 16;34 (42):5363-71
24) Zheng QF , Han L , Dong YC , Tian J, Huang W, Liu ZY, Jia XZ, Jiang T, Zhang JN, Li X*, Kang CS* and Ren H*. JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma. Neuro-Oncol 2014; 16 (9):1229-43.
25) Chang L, Su J, Jia X, Ren H*. Treating malignant glioma in Chinese patients: update on temozolomide. Onco Targets Ther. 2014; 7:235-244 (invited review)
26) Jin H, Zhang X, Su J, Teng Y, Ren H*, Yang L*. RNA interference-mediated knockdown of translationally controlled tumor protein induces apoptosis and inhibits growth and invasion in glioma cells. Mol Med Rep. 2015 Nov;12(5):6617-25
27) Jia X, Li J, Shi D, Zhao Y, Dong Y, Ju H, Yang J, Sun J, Li X*, Ren H*. Grouping annotations on the subcellular layered interactome demonstrates enhanced autophagy activity in a recurrent experimental autoimmune uveitis T cell line. PLoS One. 2014; 9 (8):e104404.
28) Li Y, Xu J, Ju H, Xiao Y, Chen H, Lv J, Shao T, Bai J, Zhang Y, Wang L, Wang X, Ren H*, Li X* A network-based, integrative approach to identify genes with aberrant co-methylation in colorectal cancer. Mol Biosyst. 2014;10 (2):180- 90
29) Hu MH, Zheng QF, Jia XZ, Li Y, Dong YC, Wang CY, Lin QY, Zhang FY, Zhao RB, Xu HW, Zhou JH, Yuan HP, Zhang WH, Ren H*. Neuroprotection effect of Interleukin-17 secreted by reactive astrocytes is emerged from a high-level IL-17-containing environment during acute neuroinflammation. Clin Exp Immunol 2014;175 (2):268-84 (cover story)
30) Li Y, Xu J, Chen H, Bai J, Li S, Zhao Z, Shao T, Jiang T, Ren H*, Kang C*, Li X*. Comprehensive analysis of the functional microRNA–mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. Nucleic Acids Res. 2013 Dec 1; 41(22):e203
31) Wen-Jing Xing1, Yan Zou, Qing-Lian Han, Yu-Cui Dong, Zhen-Ling Deng, Xiao-Hong Lv, Tao Jiang, Huan Ren*. Effects of epidermal growth factor receptor and phosphatase and tensin homologue gene expression on the inhibition of U87MG glioblastoma cell proliferation induced by protein kinase inhibitors. Clin Exp Pharmacol Physiol 2013 Jan;40(1):13-21
32) Chunying Pei, Hui Chen, Xiuzhi Jia, Lei Yan, Yan Zou, Chuanlu Jiang, Hua Jin, Chunsheng Kang, Tao Jiang, Huan Ren*. A high frequency of MSH6 G268A polymorphism and survival association in glioblastoma. Int J Neurosci 2013 Feb;123(2):114-20
33) Sui M, Lin Q, Xu Z, Han X, Xie R, Jia X, Guo X, Zhang W, Guan X, Ren H*. Simultaneous positivity for anti-DNA, anti-nucleosome and anti-histone antibodies is a marker for more severe lupus nephritis. J Clin Immunol. 2013;33 (2):378-87
34) Xing WJ, Zou Y, Han QL, Dong YC, Deng ZL, Lv XH, Jiang T, Ren H*. Effects of EGFR and PTEN gene expressions on the inhibition of U87MG glioblastoma cell proliferation induced by protein kinase inhibitors. Clin Exp Pharmacol Physiol. 2013;40 (1):13-21
35) Pei C, Chen H, Jia X, Yan L, Zou Y, Jiang C, Jin H, Kang C, Jiang T, Ren H*. A high frequency of MSH6 G268A polymorphism and survival association in glioblastoma. Int J Neurosci 2013; 123 (2):114-20.
36) Xiao Y, Fan H, Zhang Y, Xing W, Ping Y, Zhao H, Xu C, Li Y, Wang L, Li F, Hu J, Huang T, Lv Y, Ren H*, Li X*. Systematic identification of core transcription factors mediating dysregulated links bridging inflammatory bowel diseases and colorectal. PLoS One. 2013; 8 (12):e83495.
37) Jia X, Hu M, Lin Q, Ren H Association of the IRF5 rs2004640 polymorphism with rheumatoid arthritis: a meta-analysis. Rheumatol Int. 2013;33 (11):2757-61
38) Fang-Hao Lu 1, Song-Bin Fu, Xiaoning Leng, Xinying Zhang, Shiyun Dong, Ya-Jun Zhao, Huan Ren, Hulun Li, Xin Zhong, Chang-Qing Xu, Wei-Hua Zhang. Role of the calcium-sensing receptor in cardiomyocyte apoptosis via the sarcoplasmic reticulum and mitochondrial death pathway in cardiac hypertrophy and heart failure. Cell Physiol Biochem 2013; 31(4-5):728-43
39) Runtao Gan1, Guangxia Hu, Yajun Zhao, Hulun Li, Zhanfeng Jin, Huan Ren, Shiyun Dong, Xin Zhong, Hongzhu Li, Baofeng Yang, Changqing Xu, Fanghao Lu, Weihua Zhang. Post-conditioning protecting rat cardiomyocytes from apoptosis via attenuating calcium-sensing receptor-induced endo(sarco)plasmic reticulum stress. Mol Cell Biochem 2012 Feb;361(1-2):123-34
40) Shi M, Huang R, Pei C, Jia X, Jiang C, Ren H* TP53 codon 72 polymorphism and glioma risk: A meta-analysis, Oncology Letters. 2012; 3(3):599-606.
41) Dong Y, Han Q, Zou Y, Deng Z, Lu X, Wang X, Zhang W, Jin H, Su J, Jiang T, Ren H*. Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells. Mol Cell Biochem. 2012; 370 (1-2):89-102.
42) He S, Wang C, Dong H, Xia F, Zhou H, Jiang X, Pei C, Ren H, Li H, Li R, Xu H. Immune-related GTPase M1 (IRGM1) regulates neuronal autophagy in a mouse model of stroke. Autophagy 2012;8 (11):1621-7.
43) Xiao Y, Guan J, Ping Y, Xu C, Huang T, Zhao H, Fan H, Li Y, Lv Y, Zhao T, Dong Y, Ren H, Li X. Prioritizing cancer-related key miRNA-target interactions by integrative genomics. Nucleic Acids Res. 2012; 40 (16):7653-65.
44) Xu J, Li CX, Lv JY, Li YS, Xiao Y, Shao TT, Huo X, Li X, Zou Y, Han QL, Li X*, Wang LH*, Ren H*. Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA Target-Dysregulated Network: Case Study of Prostate Cancer. Mol Cancer Ther. 2011; 10 (10):1857-66.
45) Dong Y, Jia L, Wang X, Tan X, Xu J, Deng Z, Jiang T, Rainov NG, Li B, Ren H*. Selective inhibition on PDGFR by imatinib elicits sustained activation of ERK and downstream receptor signaling in malignant glioma cells. Int J Oncol. 2011; 38 (2):555-69.
46) Jia X, Hu M, Wang C, Wang C, Zhang F, Han Q, Zhao R, Huang Q, Xu H, Yuan H, Ren H*. Coordinated gene expression of Th17- and Treg-associated molecules correlated with resolution of the monophasic experimental autoimmune uveitis. Mol Vis. 2011; 7:1493-507.
47) Li X, Wang Q, Zheng Y, Lv S, Ning S, Sun J, Huang T, Zheng Q, Ren H, Xu J, Wang X, Li Y. Prioritizing human cancer microRNAs based on genes' functional consistency between microRNA and cancer. Nucleic Acids Res. 2011; 39 (22):e153.
48) Zheng H, Liu J, Liu C, Lu F, Zhao Y, Jin Z, Ren H, Leng X, Jia J, Hu G, Dong S, Zhong X, Li H, Yang B, Xu C, Zhang W. Calcium-sensing receptor activating phosphorylation of PKCδ translocation on mitochondria to induce cardiomyocyte apoptosis during ischemia/reperfusion. Mol Cell Biochem. 2011; 358 (1-2):335-43.
49) Xing WJ, Kong FJ, Li GW, Qiao K, Zhang WH, Zhang L, Bai SZ, Xi YH, Li HX, Tian Y, Ren H, Wu LY, Wang R, Xu CQ. Calcium-sensing receptors induce apoptosis during simulated ischaemia-reperfusion in Buffalo rat liver cells. Clin Exp Pharmacol Physiol. 2011; 38 (9):605-12.
50) Lu FH, Tian Z, Zhang WH, Zhao YJ, Li HL, Ren H, Zheng HS, Liu C, Hu GX, Tian Y, Yang BF, Wang R, Xu CQ. Calcium-sensing receptors regulate cardiomyocyte Ca2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation. J Biomed Sci. 2010;17; 17: 50.
51) Shiyun Dong1, Zongyan Teng, Fang-Hao Lu, Ya-Jun Zhao, Hulun Li, Huan Ren, He Chen, Zhen-Wei Pan, Yan-Jie Lv, Bao-Feng Yang, Ye Tian, Chang-Qing Xu, Wei-Hua Zhang.Post-conditioning protects cardiomyocytes from apoptosis via PKC(epsilon)-interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk. Mol Cell Biochem 2010 Aug;341(1-2):195-206.
52) Dong S, Teng Z, Lu FH, Zhao YJ, Li H, Ren H, Chen H, Pan ZW, Lv YJ, Yang BF, Tian Y, Xu CQ, Zhang WH. Post-conditioning protects cardiomyocytes from apoptosis via interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk. Mol Cell Biochem. 2010; 341(1-2):195-206.
53) Lu F, Tian Z, Zhang W, Zhao Y, Bai S, Ren H, Chen H, Yu X, Wang J, Wang L, Li H, Pan Z, Tian Y, Yang B, Wang R, Xu C. Calcium-sensing receptors induce apoptosis in rat cardiomyocytes via plasmic reticulum pathway during hypoxia/reoxygenation. Basic Clin Pharmacol Toxicol. 2010;106 (5):396-405.
54) Ren H*, Tan XQ, Dong YC, Giese A, Rainov NG. Differential effect of imatinib and synergism of combination treatment with chemotherapeutic agents in malignant glioma cells. Basic Clin Pharmacol Toxicol. 2009;104:241-252
55) Zhang Wei, Qiu Xiao-guang, Chen Bao-shi, Li Shou-wei, Cui Yun, Ren Huan and Jiang Tao. Antiangiogenic therapy with bevacizumab in recurrent malignant gliomas: analysis of the response and core pathway aberrations. Chin Med J 2009; 122 (11):1250-1254.
56) Li SW, Qiu XG, Chen BS, Zhang W, Ren H, Wang ZC, Jiang T. Prognostic factors influencing clinical outcomes of glioblastoma multiforme. Chin Med J 2009;122 (11):1245-9
57) Ren H*, Yang BF, Rainov NG. Receptor tyrosine kinases as therapeutic targets for malignant glioma. Rev Recent Clin Trials 2007; 2 (2) 87-101 (invited review)
58) Ren H, Giese A, Walker C, Pazmany L, Pelech S, Rainov NG Biological activity of the receptor tyrosine kinase inhibitor Imatinib mesylate (STI571) in malignant glioma. Neuro-Oncology 2004; 335: ET-20
59) Rainov NG, Ren H. Clinical trials with retrovirus mediated gene therapy--what have we learned? J Neurooncol. 2003 Dec; 65 (3): 227-36.
60) Rainov NG, Ren H. Gene therapy for human malignant brain tumors. Cancer J. 2003 May-Jun; 9 (3): 180-8.
61) Ren H, Boulikas T, Soling A, Warnke PC, Rainov NG. Immunogene therapy of recurrent glioblastoma multiforme with a liposomally encapsulated replication-incompetent Semliki forest virus vector carrying the human interleukin-12 gene--a phase I/II clinical protocol. J Neurooncol. 2003 Aug-Sep; 64(1-2): 147-54.
62) Rainov NG, Ren H. Oncolytic viruses for treatment of malignant brian tumors. Acta Neurochir Suppl. 2003; 88:113-23
63) Ren Huan, Xu Hongwei, Song Yinghui, Li Hulun, Zhong Zhaohua, Xing Shuxian, Tian jingxian. The proliferation of CIK cells and its cytotoxicity on tumor cells in vitro. 中國(guó)免疫學(xué)雜志（Chinese Journal of Immunology）, 1998, 14(6):406-40
64) Xu Hongwei,Wu Changyou,Li Bo, Ren Huan, Zhong Zhaohua, Li Hulun, Xing Shuxian, Tian Jingxian. Synergistic inducement of proliferation and antitumor activity of human PBMC by IL-12, IL-7 and IL-2 in vitro. 中國(guó)免疫學(xué)雜志（Chinese Journal of Immunology）, 1998, 14(5):338-341
# 另外發(fā)表會(huì)議論文和中文研究論文80篇（省略）
已出版免疫學(xué)等教材、學(xué)術(shù)專著；作為課題負(fù)責(zé)人主持教學(xué)改革課題及獲獎(jiǎng)等
1. 編者 《醫(yī)學(xué)免疫學(xué)》第二版 2023 高教出版社（高等學(xué)?！笆奈濉贬t(yī)學(xué)規(guī)劃新形態(tài)教材）ISBN-9787040589009；390000字
2. 副主編參加編寫《醫(yī)學(xué)免疫學(xué)-學(xué)習(xí)指導(dǎo)與實(shí)驗(yàn)指南》國(guó)家衛(wèi)生健康委員會(huì)“十四五”規(guī)劃教材《醫(yī)學(xué)免疫學(xué)》第5版配套教材；人民衛(wèi)生出版社 2022 ISBN 9787117295895
3. 副主編參加編寫國(guó)家級(jí)教材《醫(yī)學(xué)免疫學(xué)》案例版第三版；科學(xué)出版社2021；中國(guó)科學(xué)院教材建設(shè)專家委員會(huì)規(guī)劃教材ISBN-9787030667038
4. 副主編（數(shù)字課程）參與編寫《醫(yī)學(xué)免疫學(xué)》雙語(yǔ)版第四版（高教出版社2020，國(guó)家級(jí)“十二五”規(guī)劃教材；ISBN-978704054697）
5. 醫(yī)學(xué)顧問(wèn)參與編寫《醫(yī)學(xué)英語(yǔ)-術(shù)語(yǔ)實(shí)用教程》（主編孫慶祥 復(fù)旦大學(xué)出版社2020，醫(yī)學(xué)八年制醫(yī)學(xué)英語(yǔ)教材 ISBN-9787309150841）
6. 副主譯 《呼吸疾病臨床表現(xiàn)與評(píng)估》第六版 主審 王辰；主譯 陳宏；人民軍醫(yī)出版社 2019年；ISBN 9787509192399；原著者： Terry Des Jartins and George G Burtons
7. 主編 Tyrosine Kinases as Druggable Targets in Cancer; www.IntechOpen.com 2019; ISBN-978-1-78984-809-0 (原版eBook)
8. 編者 《免疫與疾病的戰(zhàn)爭(zhēng)》科技民生報(bào)告叢書 中國(guó)科學(xué)技術(shù)出版社 2019年ISBN-978-7-5046-8225-3
9. 編者《人體健康與免疫叢書》中年篇 陳麗華主編 人民衛(wèi)生出版社 2019 ISBN-978-7-117-28186-7
10. 編者：Receptor Tyrosine Kinase Interaction with the Tumor Microenvironment in Malignant Progression of Human Glioblastoma; In: Glioma- Contemporary Diagnostic and Therapeutic Approaches. IntechOpen 2018; ISBN-978-953-51-6182-0 (原版eBook)
11. 編者《人體健康與免疫叢書》常見(jiàn)問(wèn)題篇 曹雪濤主編 人民衛(wèi)生出版社 2017 ISBN-978-7-117-25784-8
12. 編者《醫(yī)學(xué)免疫學(xué)》雙語(yǔ)版（第三版）全國(guó)高等學(xué)校"十二五"醫(yī)學(xué)規(guī)劃教材；高等教育出版社 2016 ·iCourse 配套教材（副主編）ISBN-9787040444674 編寫：T淋巴細(xì)胞、B淋巴細(xì)胞兩章
13. 編者：《醫(yī)學(xué)免疫學(xué)》國(guó)家醫(yī)學(xué)電子書包；曹雪濤主編；人民軍醫(yī)電子出版社 2014年www.imed.org.cn；編寫：第十章 T淋巴細(xì)胞及其介導(dǎo)的細(xì)胞免疫應(yīng)答
14. 副主編，高等學(xué)校醫(yī)學(xué)規(guī)劃教材《醫(yī)學(xué)免疫學(xué)》第六版 呂昌龍等主編 高教出版社2008年ISBN-9787040216516；第七版 2012年ISBN-9787040347104；并編寫：抗體、細(xì)胞因子兩章
15. 主編：醫(yī)學(xué)免疫學(xué)復(fù)習(xí)指南和題集（高等學(xué)校醫(yī)學(xué)規(guī)劃教材配套用書）高等教育出版社2010年 ISBN-9787040288698
16. 主編：《醫(yī)學(xué)免疫學(xué)常用實(shí)驗(yàn)技術(shù)》 高等教育出版社；2011年 ISBN-9787040322255
17. 譯者：圖解免疫學(xué)（美）多恩等主編 呂昌龍 主譯 科學(xué)出版社；2011年 ISBN-9787030306531主譯：固有免疫細(xì)胞、移植免疫兩章
18. 編者：《醫(yī)學(xué)免疫學(xué)》第二版 高曉明 主編 高等教育出版社；2011；ISBN-9787040297706；編寫：主要組織相容性復(fù)合體（MHC）
19. 編者：醫(yī)學(xué)免疫學(xué)（雙語(yǔ)教學(xué)）“十一.五”規(guī)劃教材，孫汶生主編 高等教育出版社 2010；ISBN-704030262；編寫：T淋巴細(xì)胞、B淋巴細(xì)胞兩章
20. 編者：臨床免疫學(xué)(供基礎(chǔ)預(yù)防臨床口腔醫(yī)學(xué)類專業(yè)用全國(guó)高等醫(yī)藥院校教材) 王華民等主編 軍事醫(yī)學(xué)科學(xué)出版社 2010 ISBN-9787802454200；編寫：生殖免疫學(xué)、呼吸系統(tǒng)免疫性疾病兩章
21. 編者：醫(yī)學(xué)免疫學(xué)（“十一五”國(guó)家規(guī)劃教材）安云慶等主編 北京大學(xué)醫(yī)學(xué)出版社2009；ISBN-9787811167986；編寫細(xì)胞因子一章
22. 編者：醫(yī)學(xué)免疫學(xué)-復(fù)習(xí)考試指導(dǎo) 中國(guó)協(xié)和醫(yī)科大學(xué)出版社2009年ISBN-9787811360974
23. 編者：腦腫瘤的化學(xué)治療 江濤等主編 人民衛(wèi)生出版社 2008年ISBN-9787117104098編寫：腦膠質(zhì)瘤的分子靶向治療一章
24. 編者：生物化學(xué)與分子生物學(xué)（原理與應(yīng)用）臺(tái)灣 合記圖書出版社 2006年ISBN-9861262938
25. 譯者：SMITH人類先天性畸形圖譜 傅松濱主譯 人民衛(wèi)生出版社 2007年ISBN-9787117084895
26. 編者：Rainov NG, Ren H: Gene therapy for human malignant brain tumors. In: Glioblastoma multiforme (Markert J, DeVita Jr VT, Rosenberg SA, Hellman S, eds.), Jones & Bartlet Publ., 2004年 ISBN 0763726400, pp 249-265 (原版書)
27. 編者：Rainov NG, Ren H: Oncolytic viruses for treatment of malignant brain tumours. Acta Neurochir Suppl 88 (2003) (WestphaI M, Tonn JC, Ram Z eds. Local therapies for glioma. Present status and future developments. ISBN 3211403558, Springer Wien New York) (原版書)
28. 主持：免疫學(xué)課程教研室建設(shè)。廣東省高校教學(xué)質(zhì)量與教學(xué)改革工程項(xiàng)目（Y01411857）2024-2026
29. 主持：醫(yī)學(xué)免疫學(xué)線上線下混合式金課建設(shè)。廣東省本科高校教學(xué)質(zhì)量與教學(xué)改革工程項(xiàng)目（Y01411837）2021-2023
30. 主持：醫(yī)學(xué)免疫學(xué)混合式教學(xué)模式探索。南方科技大學(xué)校級(jí)教學(xué)改革課題，2019-2021 已結(jié)題
31. 主持：在醫(yī)學(xué)免疫學(xué)教學(xué)中整合基礎(chǔ)知識(shí)與臨床實(shí)踐、大班與個(gè)性化教學(xué)模式的新探索。黑龍江省高等教育學(xué)會(huì)“十二五”規(guī)劃課題（重點(diǎn)項(xiàng)目）2012-2016 已結(jié)題
32. 主持：在醫(yī)學(xué)免疫學(xué)教學(xué)體系中探索基于團(tuán)隊(duì)學(xué)習(xí)（TBL）教學(xué)模式的系列性研究。黑龍江省教育科學(xué)規(guī)劃課題， 2011-2013 已結(jié)題
33. 教學(xué)獎(jiǎng)：改革醫(yī)學(xué)免疫學(xué)教學(xué)模式，提高學(xué)生綜合素質(zhì)和創(chuàng)新能力的初步探索。教學(xué)改革研究課題2008年獲黑龍江省高等教育學(xué)會(huì)一等獎(jiǎng)（第一名）、2010年獲黑龍江省教委二等獎(jiǎng)（第一名）
主講課程（1997-）：
1.《醫(yī)學(xué)免疫學(xué)》本科生（哈爾濱醫(yī)科大學(xué)、南方科技大學(xué)）
2. 《生物醫(yī)學(xué)基礎(chǔ)》本科生（南方科技大學(xué)）
3. 《English for Medical Purposes》Clinical Medicine 本科生（南方科技大學(xué)）
4. 《腫瘤免疫學(xué)》研究生（哈爾濱醫(yī)科大學(xué)）
5. 《分子免疫學(xué)進(jìn)展》研究生（哈爾濱醫(yī)科大學(xué)）
6. 《科學(xué)寫作與交流》研究生（南方科技大學(xué)）