師資
個(gè)人簡介
劉泉，醫(yī)學(xué)博士，南方科技大學(xué)醫(yī)學(xué)院聯(lián)合黨委副書記、醫(yī)學(xué)院聯(lián)合分工會(huì)主席、中國生物醫(yī)學(xué)工程學(xué)會(huì)免疫治療工程分會(huì)移植免疫專業(yè)委員會(huì)副主任委員、副教授、研究員、副主任醫(yī)師，博士生導(dǎo)師。劉泉博士于哈爾濱醫(yī)科大學(xué)獲醫(yī)學(xué)學(xué)士（2002）、碩士（2005）、博士（2011）學(xué)位。歷任哈爾濱醫(yī)科大學(xué)附屬第二醫(yī)院心臟大血管外科住院醫(yī)師、主治醫(yī)師、副主任醫(yī)師。2009年至2017年，在匹茲堡大學(xué)Thomas E. Starzl移植研究所從事移植免疫學(xué)、炎癥調(diào)控和IL-33免疫生物學(xué)等方面科學(xué)研究。2007和2008年兩次獲得黑龍江省科學(xué)技術(shù)二等獎(jiǎng)，2013年獲美國移植協(xié)會(huì)(AST)和美國移植外科醫(yī)生協(xié)會(huì)(ASTS)聯(lián)合頒發(fā)的青年科學(xué)家獎(jiǎng)。移植免疫學(xué)研究成果被寫入經(jīng)典免疫學(xué)教材Janeway’s Immunobiology (10th Ed, 2022)。
研究領(lǐng)域
1、腫瘤免疫及免疫治療。
2、神經(jīng)-免疫-代謝的相互作用，特別是上皮細(xì)胞因子（如IL-33）、神經(jīng)遞質(zhì)（如CGRP、NMU、NE等）等對ILC及Treg的免疫生物學(xué)作用；
3、移植免疫。
主要科學(xué)發(fā)現(xiàn)
1、以移植物內(nèi)供者樹突狀細(xì)胞為例，證明了供者細(xì)胞產(chǎn)生的外泌體是移植抗原提呈半直接途徑的物質(zhì)基礎(chǔ)。
2、發(fā)現(xiàn)了移植物內(nèi)受者來源的抗原提呈細(xì)胞維持移植排斥反應(yīng)的作用。
3、發(fā)現(xiàn)了急性肺損傷過程中Treg和IL-33對組織修復(fù)的調(diào)節(jié)作用。
科研成果
1、關(guān)于移植抗原提呈機(jī)制的研究成果，被寫入2022年7月出版的經(jīng)典免疫學(xué)教材Janeway’s Immunobiology, 10th Ed (Chapter 15 Autoimmunity and Transplantation, Section 21 Alloreactive T cells reject transplanted organs by direct and indirect allorecognition)。
2、論文發(fā)表：發(fā)表SCI論文22篇，其中IF>20的期刊收錄3篇，影響因子>10的期刊收錄6篇，Nature Index期刊收錄5篇。中文發(fā)表論文6篇。
3、基金項(xiàng)目：曾主持國家自然科學(xué)基金青年基金1項(xiàng)，已順利結(jié)題；現(xiàn)主持國家自然科學(xué)基金面上項(xiàng)目1項(xiàng)。
工作經(jīng)歷
2018.08-至今 副教授，南方科技大學(xué)醫(yī)學(xué)院
2014.03-2017.04 Research Associate
T.E. Starzl Transplantation Institute, University of Pittsburgh, USA
2014.09-2018.08 副主任醫(yī)師, 心血管外科，哈爾濱醫(yī)科大學(xué)附屬第二醫(yī)院
2008.09-2014.08 主治醫(yī)師, 心血管外科，哈爾濱醫(yī)科大學(xué)附屬第二醫(yī)院
2005.07-2008.08 住院醫(yī)師, 心血管外科，哈爾濱醫(yī)科大學(xué)附屬第二醫(yī)院
教育背景
1997.09-2002.06 臨床醫(yī)學(xué) 本科 哈爾濱醫(yī)科大學(xué)
2002.09-2005.06 外科學(xué)（胸心外） 碩士 哈爾濱醫(yī)科大學(xué)
2008.09-2011.12 外科學(xué)（胸心外） 博士 哈爾濱醫(yī)科大學(xué)
2009.02-2009.08 臨床心／肺移植觀摩
Presbyterian Hospital, University of Pittsburgh Medical Center, USA
2009.12-2012.03 Research fellow
T.E. Starzl Transplantation Institute, University of Pittsburgh, USA
2012.03-2014.02 博士后
T.E. Starzl Transplantation Institute, University of Pittsburgh, USA
已發(fā)表學(xué)術(shù)論文
論著
1. Li T, Zhang Z, Bartolacci JG, Dwyer GK , Liu Q, Mathews L, Velayutham M, Roessing A, Lee YC, Dai H, Shiva S, Oberbarnscheidt MH, Dziki JL, Mullett SJ, Wendell SG, Wilkinson JD, Webber SA, Wood-Trageser MA, Watkins SC, Demetris AJ, Hussey GS, Badylak SF, Turnquist HR. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. 2020;130:5397-5412.（Nature Index期刊，影響因子19.456）
2. Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A Geller. iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice. Mol Med. 2020;26:56.
3. Xiao F, Lin L, Chao Z, Shao C, Chen Z, Wei Z, Lu J, Huang Y, Li L, Liu Q, Liang Y, Tian L. Organic Spherical Nucleic Acids for the Transport of a NIR-II-Emitting Dye Across the Blood–Brain Barrier. Angew Chem Int Ed Engl. 2020; 59:9702-9710. (Nature Index期刊，影響因子16.823)
4. Lin L, Li Y, Liu M, Li Q, Liu Q#, Li R#. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging. 2020;12:1685-1703. （#共同通訊作者，影響因子5.955）
5. Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR. IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury. JCI Insight. 2019;4(6). pii: 123919. （影響因子9.484）
6. Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016;126:2805-20. （Nature Index 期刊，影響因子19.456，高被引論文）
7. Zhuang Q*, Liu Q*, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016;7:12623. （*共同第一作者，Nature Index 期刊，影響因子17.694）
8. Liu Q, Wang Y, Nakao A, Zhang W, Gorantla V, Zheng XX. Heart allograft tolerance induced and maintained by vascularized hind-limb transplant in rats. Clin Dev Immunol. 2013; 2013:483856.
9. Matta BM, Reichenbach DK, Zhang X, Mathews L, Koehn BH, Dwyer GK, Lott JM, Uhl FM, Pfeifer D, Feser CJ, Smith MJ, Liu Q, Zeiser R, Blazar BR, Turnquist HR. Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GVHD. Blood. 2016;128:427-39. (影響因子25.476)
10. Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH1, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015;125:3183-92. (影響因子25.476)
11. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39. (影響因子12.067)
12. Rosborough BR, Ra?ch-Regué D, Liu Q, Venkataramanan R, Turnquist HR, Thomson AW. Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant. 2014;14:2173-80. (影響因子9.369)
13. Matta BM, Lott JM, Mathews LR, Liu Q, Rosborough BR, Blazar BR, Turnquist HR. IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J Immunol. 2014;193:4010-20. (影響因子5.426)
14. Rosborough BR, Mathews LR, Matta BM, Liu Q, Ra?ch-Regué D, Thomson AW, Turnquist HR.Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. J Immunol. 2014;192:3470-3. (影響因子5.426)
15. Du Q, Zhang X, Liu Q, Zhang X, Bartels C, Geller DA. Nitric Oxide Production Upregulates Wnt/β-catenin Signaling By Inhibiting Dickkopf-1. Cancer Res. 2013; 73: 6526-37. （Nature Index 期刊, 影響因子13.312）
16. Cheng L, Guo H, Qiao X, Liu Q, Nie J, Li J, Wang J, Jiang K. T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading. Diagn Pathol. 2013;8:168.
17. Zhang D, Shen M, Mikita A, Zhang W, Liu Y, Liu Q, Dai Y, Zhang C, Zheng S, Zheng XX. Targeting uncoupling protein-2 improves islet graft function. Cell Transplant. 2011;20:421-9.
18. Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Stolz DB, Zheng XX, Demetris AJ, Liew FY, Wood KJ, Thomson AW. IL-33 expands suppressive CD11b+ Gr-1int and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol. 2011; 187: 4598-610. (影響因子5.426)
19. Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010; 116: 2694-705. (影響因子25.476)
20. 刁力為,劉大勇,葉明,劉泉,亓峰,孫振東,陳子道,姚志發(fā),吳乃石.熱休克預(yù)適應(yīng)對心臟移植供心保護(hù)作用的實(shí)驗(yàn)研究[J].哈爾濱醫(yī)科大學(xué)學(xué)報(bào),2010,44(05):443-446.
21. 吳乃石,刁力為,劉泉,趙林,亓鋒,劉大勇.托拉塞米在重癥心臟聯(lián)合瓣膜置換病人圍手術(shù)期中的應(yīng)用[J].中國新藥與臨床雜志,2006(10):753-755.
22. 劉泉,吳乃石,孫露,趙林林,刁力為,陳子道,杜金榮.嬰兒多發(fā)性心臟橫紋肌瘤一例[J].中華外科雜志,2006(06):368.
23. 劉泉,臧旺福,田海.一種新的大鼠同種主動(dòng)脈瓣異位移植模型[J].中華實(shí)驗(yàn)外科雜志,2005(10):114-115.
綜述與述評
24. Liu Q, Turnquist HR. Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant. 2016;21:45-52.
25. Liu Q, Turnquist HR. Implications for Interleukin-33 in solid organ transplantation. Cytokine. 2013;62:183-94.
26. 劉泉,楊木清,代賀龍.匹茲堡大學(xué)Starzl移植研究所學(xué)習(xí)期間的見聞與思考[J].實(shí)用器官移植電子雜志,2018,6(06):477-478.
27. 劉泉,齊忠權(quán).移植免疫與器官再生的研究進(jìn)展[J].實(shí)用器官移植電子雜志,2018,6(02):90-92.