師資
個(gè)人簡(jiǎn)介：
胡堅(jiān)楊博士，南方科技大學(xué)醫(yī)學(xué)院生物化學(xué)系研究助理教授，副研究員。于2020年博士畢業(yè)于香港城市大學(xué)，期間主要研究1）三陰性乳腺癌（TNBC）特異性超級(jí)增強(qiáng)子對(duì)關(guān)鍵轉(zhuǎn)錄因子的調(diào)控；2）TCOF1蛋白調(diào)控三陰性乳腺癌的細(xì)胞干性。于香港城市大學(xué)進(jìn)行博士后訓(xùn)練期間研究外泌體對(duì)三陰性乳腺癌轉(zhuǎn)移的影響。2021年7月加入南方科技大學(xué)醫(yī)學(xué)院洪鑫課題組，主要利用循環(huán)腫瘤細(xì)胞等模型研究腫瘤細(xì)胞的衰老、轉(zhuǎn)移。研究的總體目標(biāo)是為腫瘤的治療提供潛在的藥物靶點(diǎn)。目前已在 Nature communication，British Journal of Cancer，Biochemical Pharmacology等期刊發(fā)表13篇科技論文，總引用大于480，H-index為10。申請(qǐng)中國(guó)專利3項(xiàng)，美國(guó)專利2項(xiàng)。獲國(guó)家自然科學(xué)基金青年項(xiàng)目，深圳市科創(chuàng)委-優(yōu)秀科技創(chuàng)新人才培養(yǎng)項(xiàng)目（青年項(xiàng)目），中國(guó)博士后面上項(xiàng)目以及廣東省海外博士后人才支持項(xiàng)目資助。
教育背景：
2017.09-2020.10 博士，生物醫(yī)學(xué)，香港城市大學(xué)
2012.09-2015.06 碩士，藥理學(xué)， 暨南大學(xué)
2008.09-2012.06 學(xué)士，藥學(xué)， 廣州中醫(yī)藥大學(xué)
工作經(jīng)歷：
2023.08-今 研究助理教授，南方科技大學(xué) 醫(yī)學(xué)院
2021.07-2023.07 博士后， 南方科技大學(xué) 醫(yī)學(xué)院
2020.10-2021.06 博士后， 香港城市大學(xué) 生物醫(yī)學(xué)系
2017.02-2017.08 研究助理， 香港城市大學(xué) 生物醫(yī)學(xué)系
研究領(lǐng)域：
1）腫瘤細(xì)胞衰老調(diào)控
2）腫瘤轉(zhuǎn)移機(jī)制
3）腫瘤微環(huán)境中細(xì)胞間通訊，如外泌體介導(dǎo)的細(xì)胞間通訊
發(fā)表論文：
1. Huang H#, Hu JY#, Maryam A, Huang QH, Zhang YC, Ramakrishnan S, Li JY, Ma HY, Ma V, Cheuk W, So G, Wang W, Cho W, Zhang L, Chan KM, Wang X* & Chin YR*. Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling. Nature communications, 2021, 12:2242. (Co-first author, IF:17.694).
2. Hu JY, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma VW, Cheuk W, So GY, He Q, Lau CG, Zhang L, Cho WC, Chan KM, Wang X, Chin YR. TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumor growth, and correlates with poor prognosis. British Journal of Cancer, 2022, 126:57-71. IF:9.08.
3. Sun HY#, Ou T#, Hu JY#, Yang ZY, Lei QF, Li YQ, Wang G, Li YP, Wu K, Wang SP, Wu S. Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer. Biochemical Pharmacology, 2021, 190:114588. (# Co-first author, IF:6.1)
4. Zhuo ZZ#, Hu JY#, Chen MF, Lei XP, Deng LJ, Yao N, Peng QL, Chen ZS, Ye WC *, Zhang DM*. Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo. Scientific reports, 2015, 5: 16185. (# Co-first author, IF: 4.997)
5. Zhou M, Li WP, Li J, Xie LM, Wu RB, Wang L, Fu S, Su W, Hu JY, Li PL. Phase-separated condensate-aided enrichment of biomolecular interactions for high-throughput drug screening in test tubes. Journal of Biological Chemistry, 2020, 295(33): 11420-11434.
6. Liu JS., Huo CY, Cao HH, Fan CL, Hu JY, Deng LJ, ... Yu ZL. (2019). Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway. Phytomedicine, 2019, 61: 152843.
7. Sun HY, Huang MH, Yao N, HU JY, Li YJ, Chen LP, HU N, Ye WC, Tai WillamChi-Shing, Zhang DM, Chen SB. The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells. Biochemical Pharmacology, 2017, 146: 87-100.
8. Chen LP, Mai WQ, Chen MF, Hu JY, Zhuo ZZ, Lei XP, Deng LJ, Liu JS, Yao N, Huang MH, Peng YH, Ye WC, Zhang D. Arenobufagin inhibits prostate cancer epithelial-mesenchymal transition and metastasis by down-regulating β-catenin. Pharmacological research, 2017, 123: 130-142.
9. Chen MF, Lei XP, Shi CZ, Huang MH, Wu BJ, Li ZQ, Han WL, Du B, Hu JY, Nie QL, Mai WQ, Ma N, Xu NH, Zhang XY, Xia MH, Luo LP, Ma Ande, Li HS, Yu Q, Chen HRR, Zhang DM, Ye WC. Targeting tumor pericytes with a FAP-alpha-activated prodrug combats tumor resistance to vascular disrupting agents. Journal of Clinical Investigation, 2017, 127(10): 3689–3701.
10. Lei XP, Chen MF, Nie QL, Hu JY, Zhuo ZJ, Yiu A, Chen HR, Xu NH, Bai LL, Zhang DM*, Ye WC*. In vitro and in vivo antiangiogenic activity of desacetylvinblastine monohydrazide through inhibition of VEGFR2 and Axl pathways. American Journal of Cancer Research, 2016, 6(4):843-858.
11. Sun HY, Liu BB, Hu JY, Yang XL, Xu LJ, Chan SW, Chan CO, Daniel K.W. Mok, Zhang DM*, Ye WC*, Chen SB*. New cycloartane triterpenoid from Cimicifuga foetida induces mitochondrial apoptosis in human breast carcinoma MCF-7 cells via inhibiting Raf/MEK/ERK pathway and Akt phosphorylation. Chinese Medicine, 2016, 11(1): 1-11.
12. Zhang W, Huang XJ, Zhang SY, Zhang DM, Jiang RW, Hu JY, Zhang XQ, Wang L*, Ye WC*. Geleganidines A–C, Unusual Monoterpenoid Indole Alkaloids from Gelsemium elegans. Journal of natural products, 2015, 78(8): 2036-2044.
13. Hu JY, Chen MF, Lei XP, Zhuo ZJ, Sun HY, Chen ZS, Shi Z, Zhang DM*, Ye WC*. Bufalin induces apoptosis of MDA-MB-231 cell through activation of JNK/p53 pathway. Journal of Cancer Research Updates, 2015, 4(2): 47-53.