師資
個人簡介：
賈寧，醫(yī)學院副教授，博士生導師。入選《麻省理工科技評論》“35歲以下科技創(chuàng)新35人”亞太區(qū)榜單（2022），美國布拉瓦尼克區(qū)域青年科學家化學獎獲得者（2020）。2016年于中國科學技術大學生命學院獲得博士學位， 隨后在美國紀念斯隆凱特琳癌癥中心從事博士后研究。2021年5月加入南方科技大學醫(yī)學院。長期聚焦于細菌抗噬菌體免疫機制研究，近年來以通訊作者身份發(fā)表論文15篇 (Science 2025a, 2025b；Nature Chemical Biology 2024；Molecular Cell 2023，2019a, 2019b, 2019c；Nature Communications, 2024a,b, 2022; Nature Reviews Molecular Cell Biology, 2021； Cell Research, 2024, 2022, 2020;等)。其中，Nature Communications, 2022 被世界學術組織“Faculty Opinions (原F1000Prime)”推薦；擔任Nature、Science、Nature Microbiology、Nature Catalysis、Nature Chemical Biology等雜志審稿人。加入Journal of Biological Chemistry (JBC)、mLife期刊作為Editorial Board member。主持國自然面上、省市基金多項。
教育背景：
2006-2010 中國海洋大學， 海洋生物資源與環(huán)境，學士
2010-2016 中國科學技術大學，生物化學與分子生物學，博士 （導師周叢照、陳宇星教授）
工作經(jīng)歷：
2022.06-至今 南方科技大學醫(yī)學院，副教授
2021.05-2022.05 南方科技大學醫(yī)學院，助理教授
2017-2021 美國紀念斯隆凱特琳癌癥中心，博士后 （導師：Dinshaw J. Patel）
獲獎情況及榮譽：
2024 入選Journal of Biological Chemistry (JBC)和mLife期刊的Editorial Board member
2022 入選《麻省理工科技評論》“35歲以下科技創(chuàng)新35人”亞太區(qū)榜單（2022）
2021 深圳海外高層次人才（孔雀B類）
2020 美國布拉瓦尼克區(qū)域青年科學家化學獎 (2020 Blavatnik Regional Awards for Young Scientists Winner in Chemistry)
2016 蔡司-斑馬魚科學研究獎
2010 山東省優(yōu)秀畢業(yè)生
2007，2009 國家獎學金
研究興趣：
1）課題組通過結(jié)合生物化學、分子生物學、微生物學及結(jié)構(gòu)生物學等手段，探究微生物與宿主免疫系統(tǒng)相互作用的分子機制，尤其關注細菌和古菌免疫防御系統(tǒng)（如CRISPR-Cas適應性免疫系統(tǒng)）抵御噬菌體侵染的分子機制。
2）基于微生物與宿主免疫系統(tǒng)相互作用分子機制的理解，開發(fā)相應的生物技術工具（如CRISPR-Cas基因編輯工具）。
學術任職：
Journal of Biological Chemistry (JBC)、mLife期刊的Editorial Board member
紐約科學學會（The New York Academy of Sciences）會員
發(fā)表論文：
（#第一作者; *通訊作者 ）
1. Song, X. Y.#; Xia, Y.#; Zhang, J. T.#; Liu, Y. J.; Qi, H.; Wei, X. Y.; Hu, H.;Xia, Y.; Liu, X.; Ma, Y.F.; Jia, N.* (2025). Bacterial reverse transcriptase synthesizes long polyA-rich cDNA for anti-phage defense, Science, 2025 May 1:eads4639. doi: 10.1126/science.ads4639.
2. Hayes, V. M. #; Zhang, J. T.#; Katz, M. A.; Li, Y.; Kocsis, B.; Jia, N.*; Meeske, A. J.* (2025). RNA-mediated CRISPR-Cas13 inhibition via crRNA structural mimicry. Science, 388(6745): 387-391
3. Zhang, J.T.; Wei, X.Y.; Cui, N.; Tian, R. & Jia, N. * (2024). Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nature Chemical Biology 20, 503-511 .
4. Cui, N.#; Zhang, J.T.#; Li, Z.; Wei, X.Y.; Wang, J. and Jia, N.* (2024). Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system. Nature Communications 15, 8610 .
5. Zhang, J.T.#; Liu, X. Y.#; Li, Z.#;Wei, X.Y.; Song, X.Y.; Cui, N.; Zhong, J.; Li, H.; Jia, N.* (2024). Structure and genome editing activity of the novel CRISPR-Cas12o1 effector. Cell research. 10.1038/s41422-024-01050-y.
6. Zhang, J.T.#; Liu, X.Y.#; Li, Z.L.#; Wei, X.Y.; Song, X.Y.; Cui, N.; Zhong, J.; Li, H. and Jia, N.* (2024). Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system. Nature Communications 15, 2797.
7. Cui, N.#; Zhang, J.T.#; Li, Y.; Liu, Y.; Liu, X.Y.; Wang, C.; Huang, H.* and Jia, N.* (2023). Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment. Molecular Cell 83, 2493-2508 e2495.
8. Duan, Z.#; Zhang, X.#; Zhang, J.T.; Li, S; Liu, R.; Sun, J.; Zhao, Q.; Jia, N.; Jia, N.* and Zhu, J.K.* (2023). Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05. Cell Discovery 9, 117. 10.1038/s41421-023-00612-5.
9. Cui, N.#; Zhang, J.T.#; Li, Z.; Liu, X.Y.;Wang, C.; Huang, H.* and Jia, N.* (2022). Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nature Communications 13, 7549.
10. Patel, D.J.*; Yu, Y. and Jia, N. (2022). Bacterial origins of cyclic nucleotide-activated antiviral immune signaling. Molecular Cell 82, 4591-4610.
11. Jia, N.* & Patel, D.J.* (2022). Structure-based evolutionary relationship between IscB and Cas9. Cell Research 32, 875-877.
12. Jia, N.*; Patel. D. J.* (2021). Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins. Nature reviews. Molecular Cell Biology 22, 563-579, doi:10.1038/s41580-021-00371-9.
13. Meeske A. J.#; Jia, N.#; Cassel A.K.; Kozlova A.; Liao J.; Wiedmann M.; Patel D. J.*; Marraffini L. A.* (2020). A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Science 369, 54-59.
14. Jia, N.*; Xie, W.; De La Cruz, J.M.; Eng, E.T.; Patel, D.J.* (2020). Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Research 30, 182-184.
15. Jia, N.*; Jones, R.; Yang, G.; Ouerfelli, O.; Patel, D.J.* (2019). CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity. Molecular Cell 75, 944-956 e946.
16. Jia, N.*; Jones, R.; Sukenick, G.; Patel, D.J.* (2019). Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Molecular Cell 75, 933-943 e936.
17. Jia, N.*; Mo, C.Y.;Wang, C.; Eng, E.T.; Marraffini, L.A.; Patel, D.J.* (2019). Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Molecular Cell 73, 264-277 e265.
18. Jia, N.#; Unciuleac, M.#; Xue C.; Greene E.C.; Patel, D.J.*; Shuman, S.* (2019). Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America 116, 24507-24516.
19. Jia, N.; Liu, N.; Cheng, W.; Jiang, Y.L.; Sun, H.; Chen, L.L.; Peng, J.; Zhang, Y.; Ding, Y.H.; Zhang, Z.H.; et al. (2016). Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO reports 17, 235-248.
20. Chen, L.L.; Xie, J.; Cao, D.D.; Jia, N.; Li, Y.J.; Sun, H.; Li, W.F.; Hu, B.; Chen, Y.; Zhou, C.Z. (2018). The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection. Dev Comp Immunol 82, 49-54.
21. Zhou, K.; Jia, N.; Hu, C.; Jiang, Y.L.; Yang, J.P.; Chen, Y.; Li, S.; Li, W.F.; Zhou, C.Z. (2014). Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins 82, 3224-3229.
22. Song, N.; Jia, N.; Yanagimoto, T.; Lin, L.; Gao, T. (2013). Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region. Mitochondrial DNA 24, 705-712.
23. He, Y.X.; Zhang, N.N.; Li, W.F.; Jia, N.; Chen, B.Y.; Zhou, K.; Zhang, J.; Chen, Y.; Zhou, C.Z. (2012). N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease. Journal of molecular biology 418, 197-207.