師資
個(gè)人簡(jiǎn)介：
南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系副教授、博士生導(dǎo)師。
2006年在德國馬克斯普朗克分子遺傳所獲得功能基因組學(xué)博士學(xué)位，07年于同所建立獨(dú)立實(shí)驗(yàn)室。2009年任德國馬科斯德爾布呂克國家分子醫(yī)學(xué)中心/柏林系統(tǒng)生物醫(yī)學(xué)研究所高級(jí)研究員。2016年8月加入南方科技大學(xué)。
長期從事功能基因組、藥理學(xué)、化學(xué)生物學(xué)領(lǐng)域的研究，在新藥研發(fā)方面也富有經(jīng)驗(yàn)。聚焦功能基因組學(xué)領(lǐng)域的研究，曾建立基于細(xì)胞芯片技術(shù)的包括蛋白質(zhì)亞細(xì)胞定位，誘導(dǎo)細(xì)胞凋亡，蛋白質(zhì)－蛋白質(zhì)交互作用等多項(xiàng)高通量基因功能研究平臺(tái)。近年來，致力于發(fā)展適用于藥理學(xué)的系統(tǒng)生物學(xué)手段，特別是結(jié)合高通量測(cè)序、單細(xì)胞測(cè)序技術(shù)、空間轉(zhuǎn)錄組學(xué)技術(shù)、CRISPR基因編輯技術(shù)、蛋白組學(xué)、代謝組學(xué)等的前沿技術(shù)。已在Genome biology, Oncogene, EMBO Molecular medicine，Developmental cell等期刊, 發(fā)表40余篇研究論文，總引用近2000次，近5年引用數(shù)超1000次。H-指數(shù)18，i10-指數(shù)22。已申請(qǐng)抗腫瘤、抗新冠的天然化合物，單細(xì)胞技術(shù)等發(fā)明專利8項(xiàng)。已承擔(dān)國家和省市項(xiàng)目4項(xiàng)，總科研經(jīng)費(fèi)超560萬元。
深圳市孔雀團(tuán)隊(duì)核心成員，深圳市基因調(diào)控與系統(tǒng)生物學(xué)重點(diǎn)實(shí)驗(yàn)室核心PI?，F(xiàn)任中國藥理學(xué)會(huì)抗炎免疫專委會(huì)委員、廣東省藥理學(xué)會(huì)理事、抗炎免疫專委會(huì)主任委員。廣東歐美同學(xué)會(huì)常務(wù)理事。
教育背景：
2002.09-2006.06 德國馬普分子遺傳學(xué)研究所，功能基因組學(xué)，博士
1998.09-2001.06 華西醫(yī)科大學(xué)（后四川大學(xué)），藥學(xué)院，生藥學(xué)，碩士
1990.09-1994.06 成都中醫(yī)藥大學(xué)，中藥學(xué)，學(xué)士
工作經(jīng)歷：
2022.03-至今 南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系，副教授、研究員
2016.08-2022.03 南方科技大學(xué)生物系，獨(dú)立PI, 研究副教授，博士生導(dǎo)師
2009-2016 德國馬科斯?德爾布呂克國家分子醫(yī)學(xué)中心，高級(jí)研究員
2007-2009 德國馬普分子遺傳學(xué)研究所，青年科學(xué)家小組（化學(xué)及藥物基因組學(xué)）組長
2006-2007 德國馬普分子遺傳學(xué)研究所，博士后
2002.1-2002.10 香港浸會(huì)大學(xué)，訪問學(xué)者
1994-2002 華西醫(yī)科大學(xué)（2001年并入四川大學(xué)）藥學(xué)院，助教，講師（1999起)
獲獎(jiǎng)情況及榮譽(yù)：
2021年 深圳市產(chǎn)業(yè)發(fā)展與創(chuàng)新人才獎(jiǎng)
2020年 南方科技大學(xué)校優(yōu)秀專利獎(jiǎng)
研究領(lǐng)域：
1.基于功能基因組，特別是結(jié)合高通量測(cè)序、單細(xì)胞時(shí)空組學(xué)、CRISPR基因編輯技術(shù)的藥物功能和分子機(jī)制研究。
2. 基于精準(zhǔn)醫(yī)療的腫瘤基因組學(xué)和化學(xué)基因組學(xué)，致力于癌癥的耐藥逆轉(zhuǎn)、早期檢測(cè)和分類靶向治療。
3.結(jié)合組學(xué)、化學(xué)生物學(xué)的細(xì)胞生物學(xué)研究。尤以化合物誘導(dǎo)的細(xì)胞焦亡、線粒體功能異常、DNA損傷和修復(fù)，及其在表觀遺傳學(xué)的改變?yōu)橹饕芯糠较颉?/p>
4. 基于新作用機(jī)理的化合物（含天然產(chǎn)物）臨床前新藥研發(fā)。
學(xué)術(shù)任職：
1、 擔(dān)任中國藥理學(xué)會(huì)抗炎免疫專委會(huì)委員；
2、 擔(dān)任廣東省藥理學(xué)會(huì)理事
3、擔(dān)任廣東省藥理學(xué)會(huì)抗炎免疫專委會(huì)副主任委員；
4、擔(dān)任中藥全球化聯(lián)盟會(huì)員；
5、擔(dān)任國際化學(xué)生物學(xué)學(xué)會(huì)會(huì)員；
6、擔(dān)任德中分子醫(yī)學(xué)和分子藥學(xué)學(xué)會(huì)會(huì)員；
7、擔(dān)任廣東歐美同學(xué)會(huì)常務(wù)理事
發(fā)表論文：
1. Mingyue Wang, Qinan Hu, Tianhang Lv, Yuhang Wang, Qing Lan, Zhencheng Tu, Rong Xiang, Yanrong Wei, Kai Han, Yanru An, Mengnan Cheng, Jiangshan Xu, Miguel A.Esteban, Haorong Lu, Wangsheng Li, Shaofang Zhang, Ao Chen, Wei Chen, Yuxiang Li, Xiaoshan Wang, Xun Xu*, Yuhui Hu*, Longqi Liu*. High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae. Developmental cell，2022，Volume 57, Issue 10, Pages 1271-1283.e4
https://doi.org/10.1016/j.devcel.2022.04.006
2. Wencheng Wei, Yunfei Li, Chuanxi Wang, Sanxing Gao, Hao Wang, Yan Zhao, Ziying Gao, Yanxiang Jiang, Li Zhao, Hao Gao*, Xinsheng Yao, Yuhui Hu*. Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells. Pharmacological Research, 2022, Volume 182, 106285. https://doi.org/10.1016/j.phrs.2022.106285
3. Shuye Tian, Bin Zhang, Yuhao He, Zhiyuan Sun, Jun Li, Yisheng Li, Hongyang Yi, Yan Zhao, Xudong Zou, Yunfei Li, Huanhuan Cui, Liang Fang, Xin Gao, Yuhui Hu, Wei Chen*. CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference. Nucleic Acids Research, 2022, gkac108.
4. Weizheng Liang, Guipeng Li, Huanhuan Cui, Yukai Wang, Wencheng Wei, Siyue Sun, Diwen Gan, Rui Chen, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Wei Chen*. Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents, BMC Genomics, 2021 (in presss) DOI: 10.21203/rs.3.rs-511600/v1
5. Xudong Zou, Bernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, Liang Fang, Yuhui Hu, Wei Chen*. Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law. Life Science Alliance (2021) 5(4):e202101333.
6. Yan Zhao, Jing Sun, Yunfei Li, Zhengxuan Li, Yu Xie, Ruoqing Feng, Jincun Zhao*, Yuhui Hu*. The strand-biased transcription of SARS-CoV-2 and unbalanced inhibition by remdesivir. iScience (2021)24 (8): 102857. DOI: 10.1016/j.isci.2021.102857
7. Liang Fang, Guipeng Li, Zhiyuan Sun, Qionghua Zhu, Huanhuan Cui, Yunfei Li, Jingwen Zhang, Weizheng Liang, Wencheng Wei, Yuhui Hu & Wei Chen*. CASB: a concanavalin A‐based sample barcoding strategy for single cell Sequencing. Molecular systems biology (2021) 17 (4): e10060.
8. Zhongxiao Li, Yisheng Li, Bin Zhang, Yu Li, Yongkang Long, Juexiao Zhou, Xudong Zou, Min Zhang, Yuhui Hu*, Wei Chen*, Xin Gao*. DeeReCT-APA: Prediction of Alternative Polyadenylation Site Usage Through Deep Learning. Genomics Proteomics and Bioinformatics, (2021), In press. https://doi.org/10.1016/j.gpb.2020.05.004
9. Liang Fang*, Wen Wang, Guipeng Li, Li Zhang, Jun Li, Diwen Gan, Jiao Yang, Yisen Tang, Zewen Ding, Min Zhang, Wenhao Zhang, Daqi Deng, Zhengyu Song, Qionghua Zhu, Huanhuan Cui, Yuhui Hu and Wei Chen*. CIGAR‐seq, a CRISPR/Cas‐based method for unbiased screening of novel mRNA modification regulators. Mol Syst Biol (2020) 16:e10025.
10. Hongyang Yi, Guipeng Li, Yongkang Long, Weizheng Liang, Huanhuan Cui, Bin Zhang, Ying Tan, Yunfei Li, Luochen Shen, Daqi Deng, Yisen Tang, Chenyu Mao, Shuye Tian, Yunting Cai, Qionghua Zhu, Yuhui Hu*, Wei Chen* & Liang Fang*. Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT. Oncogene (2020)39:5152–5164. DOI: 10.1038/s41388-020-1351-z
11. Yisheng Li , Bernhard Schaefke* , Xudong Zou, Min Zhang, Florian Heyd, Wei Sun, Bin Zhang, Guipeng Li, Weizheng Liang, Yuhao He, Juexiao Zhou, Yunfei Li, Liang Fang, Yuhui Hu & Wei Chen*. Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation. Mol Syst Biol (2020) 16: e9367.
12. Xi Wang, Xintian You, Julian Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin Schuman, and Wei Chen. Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus. Nat Commun (2019) 10:5009.
13. Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty, Sebastian Fro hler, Clemens Grimm, Yuhui Hu, Bernhard Schaefke, Liang Fang, Min Zhang, Nadine Kraemer, Angela M. Kaindl*, Utz Fischer*, and Wei Chen*. A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLOS Genetics (2019) 15(10): e1008460.
14. Haiping Zhang, Linbu Liao, Yunting Cai, Yuhui Hu, Hao Wang*. IVS2vec: A tool of Inverse Virtual Screening based on word2vec and deep learning techniques, Methods (2019) 166:57–65.
15. Zhihao Xia, Yu Li , Bin Zhang, Zhongxiao Li, Yuhui Hu, Wei Chen*, and Xin Gao*. DeeReCT-PolyA: a robust and generic deep learning method for PAS identification. Bioinformatics (2019)35(14):2371–2379.
16. Wei Sun, Qingsong Gao, Bernhard Schaefke, Yuhui Hu, Wei Chen*. Pervasive allele-specific regulation on RNA decay in hybrid mice. Life science alliance (2018) 1 (2):e201800052.
17. Wang, Y., Gogol-D?ring, A., Hu, H., Fr?hler, S., Ma, Y., Jens, M., Maaskola, J., Murakawa, Y., Quedenau, C., Landthaler, M., Kalscheuer, V., Wieczorek, D., Wang, Y., Hu, Y.* and Chen, W.*. Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Mol Med. (2013) Sep;5(9):1431-42.
18. Mazin P, Xiong J, Liu X, Yan Z, Zhang X, Li M, He L, Somel M, Yuan Y, Phoebe Chen YP, Li N, Hu Y, Fu N, Ning Z, Zeng R, Yang H, Chen W*, Gelfand M*, Khaitovich P*. Widespread splicing changes in human brain development and aging. Mol Syst Biol. (2013); 9:633.
19. Li N, You X, Chen T, Mackowiak SD, Friedl?nder MR, Weigt M, Du H, Gogol-D?ring A, Chang Z, Dieterich C, Hu Y, Chen W*. Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery. Nucleic Acids Res. (2013) Apr 1;41(6):3619-34.
20. Thu-Hang Pham, Christopher Benner, Monika Lichtinger, Lucia Schwarzfischer, Yuhui Hu, Reinhard Andreesen, Wei Chen and Michael Rehli. Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states. Blood. (2012) Jun 14;119(24):e161-71.
21. Liu X, Somel M, Tang L, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y, Li N, Hu Y, Chen W, Qiu Z, P??bo S, Khaitovich P. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. (2012) Apr;22(4):611-22.
22. Somel M, Liu X, Tang L, Yan Z, Hu H, Guo S, Jiang X, Zhang X, Xu G, Xie G, Li N, Hu Y, Chen W, P??bo S, Khaitovich P. MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates. PLoS Biol. (2011) Dec;9(12):e1001214.
23. Zheng Yan, Hai Yang Hu, Xi Jiang, Vera Maierhofer, Elena Neb, Liu He, Yuhui Hu, Hao Hu, Na Li, Wei Chen, and Philipp Khaitovich. Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Res. (2011) Aug;39(15):6596-607.
24. Yuhui Hu and Michal Janitz. High-throughput subcellular protein localization using transfected-cell arrays. Methods Mol Biol. (2011);706:53-72.
25. Mehmet Somel, Song Guo, Ning Fu, Zheng Yan, Hai Yang Hu, Ying Xu, Yuan Yuan, Zhibin Ning, Yuhui Hu, Corinna Menzel, Hao Hu, Michael Lachmann, Rong Zeng, Wei Chen, and Philipp Khaitovich. MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Research (2010); 20:1207-1218.
26. Weimin Qiu, Yuhui Hu, Tom E. Andersen, Abbas Jafari, Na Li, Wei Chen, and Moustapha Kassem. Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical WNT signaling and C/EBP. J Biol Chem. (2010); 7;285(19):14438-49.
27. Yuhui Hu, Hans Lehrach and Michal Janitz. Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators. Molecular Biology Reports (2010); 37(7): 3381–3387.
28. Chen W, Ullmann R, Langnick C, Menzel C, Wotschofsky Z, Hu H, D?ring A, Hu Y, Kang H, Tzschach A, Hoeltzenbein M, Neitzel H, Markus S,Wiedersberg E, Kistner G, van Ravenswaaij-Arts CM, Kleefstra T, Kalscheuer VM, Ropers HH. Breakpoint analysis of balanced chromosome rearrangements by next-generation paired-end sequencing. Eur J Hum Genet. (2010) May;18(5):539-43.
29. Yuhui Hu, Hans Lehrach and Michal Janitz. Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods. Journal of Molecular Histology. (2009) Oct;40(5-6):343-52.
30. Fiebitz A, Nyarsik L, Haendler B, Hu YH, Wagner F, Thamm S, Lehrach H, Janitz M, Vanhecke D. High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays. BMC Genomics (2008), 9:68.
31. Y.H. Hu, H. J. Warnatz, D. Vanhecke, F. Wagner, A. Fiebitz, S. Thamm, P. Kahlem, H. Lehrach, M. L. Yaspo, and M. Janitz. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics (2006), 7:155.
32. Y.H. Hu, D. Vanhecke, M. Janitz. High-throughput subcellular protein localization using cell arrays. Biochemical Society Transaction. (2005) Dec;33(Pt 6):1407-8.
33. Liu L, Han L, Wong DYL, Yue PYK, Ha WY, Hu YH, Wang PX, Wong RNS. Effects of Si-Jun-Zi decoction polysaccharides on cell migration and gene expression in wounded rat intestinal epithelial cells. British Journal of Nutrition. (2005) 93, 21–29.
34. Hu Yuhui, ZHANG Hao, Zhang Zhi-Feng. Determine total flavonoids and scutellarin of Erigeron genus. Chin. J. Pharm. Anal. (2005) 25(1).
35. Hu Yuhui, ZHANG Hao. Chemical comparative study on the active compounds in 5 species of Erigeron. The journal of Chinese Traditional Patent Medicine (2004) Jan.
36. 張志鋒，張浩，胡宇慧，劉顯福。不同產(chǎn)地多舌飛蓬化學(xué)成分的含量測(cè)定?！吨袊褡迕耖g醫(yī)藥雜志》，2003年 2期
37. 胡宇慧，張浩等。歐洲兩地和中國西南山區(qū)飛蓬揮發(fā)油成份的比較。《華西藥學(xué)雜志》， 2001年16卷3期