師資
基本概況
南方科技大學(xué)公共衛(wèi)生及應(yīng)急管理學(xué)院副教授、研究員、博士生導(dǎo)師、應(yīng)急管理研究中心執(zhí)行主任。北京大學(xué)全球健康發(fā)展研究院兼職研究員。曾任哈佛大學(xué)醫(yī)學(xué)院講師、美國退伍軍人事務(wù)部波士頓榮軍醫(yī)院資深科學(xué)家。累計(jì)發(fā)表SCI論文100余篇，H-指數(shù)56，總引用超過2萬次，其中包括在《自然》、《自然通訊》、《血液》、《核酸研究》、《生物信息》等國際一流雜志上發(fā)表的第一作者文章。國家自然科學(xué)基金面上項(xiàng)目（2025-2027）“基于全球多人群數(shù)據(jù)的中國心腦血管疾病多基因風(fēng)險(xiǎn)智能評估研究” 項(xiàng)目負(fù)責(zé)人，國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目（2023-2025）“健康預(yù)期壽命及其價(jià)值的測算技術(shù)和影響因素與應(yīng)用研究” 課題負(fù)責(zé)人，中國民用航空局民航安全能力建設(shè)項(xiàng)目（2023）“新冠病毒新變異株疫情下的中國民航國際航線動態(tài)防控策略研究” 項(xiàng)目負(fù)責(zé)人，深圳市疾病預(yù)防控制中心 “十四五” 規(guī)劃撰稿人。2018年出版科普著作《基因的名義》（高等教育出版社），同年入選“中華優(yōu)秀科普圖書榜”。2022年出版科普著作《核酸的前世今生》（北京大學(xué)出版社）。
科研
四個Ji【基因與疾病、急救、機(jī)場】：
1. 面向常見病【心腦血管疾病】的多組學(xué)和AI數(shù)字孿生方法研究
2. 面向非常見病【如自閉癥】的多組學(xué)研究
3. 基于國際機(jī)場和機(jī)艙內(nèi)空氣及廢水采樣的疫情預(yù)警研究
4. 基于急救中心120數(shù)據(jù)的疾病譜研究
關(guān)鍵詞：全球健康，生物信息學(xué)，健康醫(yī)療大數(shù)據(jù)，人工智能
招生方向：公共衛(wèi)生與預(yù)防醫(yī)學(xué)【100401 流行病與衛(wèi)生統(tǒng)計(jì)學(xué)】；生物學(xué)【071012 生物信息與計(jì)算生物學(xué)】；基礎(chǔ)醫(yī)學(xué)【100111 人類遺傳學(xué)，100117 系統(tǒng)生物醫(yī)學(xué)】
教學(xué)
1. 本科生通識選修課《大數(shù)據(jù)里的全球健康》
本課程從大數(shù)據(jù)分析的角度，講述全球衛(wèi)生與健康領(lǐng)域的重點(diǎn)知識。覆蓋的知識點(diǎn)既有全球重大慢性疾病相關(guān)的疾病負(fù)擔(dān)與健康預(yù)期壽命測算、疾病風(fēng)險(xiǎn)預(yù)測，也有以新冠肺炎疫情為主線的全球大流行性傳染病的防控理論和科研方法。
2. 研究生核心課《人類基因組與人工智能解析》
本課程以基因組和其它多組學(xué)的傳統(tǒng)大數(shù)據(jù)分析及最前沿的AI解析為主線。這不同于以軟件開發(fā)應(yīng)用為主線的生物信息學(xué)課程，也不同于以生物學(xué)技術(shù)和遺傳疾病為主線的醫(yī)學(xué)遺傳學(xué)課程。本課程以權(quán)威期刊發(fā)表的最新研究論文為主要學(xué)習(xí)參考資料，理論和實(shí)踐相結(jié)合，致力于提升學(xué)生提煉科學(xué)問題和理清科研分析思路的能力。教學(xué)內(nèi)容包括：人類基因組學(xué)概述及近年來諾獎成果解讀、人類基因組數(shù)據(jù)AI解析、人類蛋白組數(shù)據(jù)AI解析、 基于AI的老藥新用研發(fā)應(yīng)用示例、消費(fèi)級精準(zhǔn)健康與AI解析應(yīng)用示例，等。
代表性論文（#共同一作，*通訊作者）
1. Ran Zhao, Wenyan Xian, Yihao Ma, Valerio Napolioni, Patrick WC Lau, Xiao-Li Tian, Yann Le Guen, Andre Franke, Jie Huang*. Additive association of blood group A allele with 15 cardiometabolic diseases: a UK Biobank life-course study. Cardiovascular Diabetology 24, 113
2. J Huang#*, M Güllüo?lu, O D?ring, H Wang, J Li, Y Liu. Global infectious disease surveillance: bridge a 30-metre gap between the International Civil Aviation Organization and the World Anti-Doping Agency. Journal of Global Health 15, 03010
3. Wenyan Xian, Yifan Tao, Chong You, Ruinan Sun, Janice M Ranson, Valerio Napolioni, Patrick WC Lau, Jie Huang*. Brisk Walking Pace Offsets Venous Thromboembolism Risk Equivalent to Established Monogenic Mutations. Thrombosis and Haemostasis. 2025 Jan 16
4. Huang J#*, D?ring O, GG Liu. The world needs a “pandamic” solution for a pandemic problem. China CDC Weekly. 4 (52), 1183-1184
5. Huang J#, Huffman JE#, Huang Y#, Valle ID, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási A, Huang R, Hui Q, Nguyen XT, Ho YL, Djousse? L, Lynch JA, Vujkovic M, Tcheandjieu C, Tang H, Damrauer SM, Reaven PD, Miller D, Phillips LS, Ng MCY, Graff M, Haiman CA, Loos RJF, North KE, Yengo L, Smith GD, Saleheen D, Gaziano JM, Rader DJ, Tsao PS, Cho K, Chang KM, Wilson PWF, VA Million Veteran Program, Sun YV*, O’Donnell CJ. Genomics and phenomics of body mass index reveals a complex disease network. Nature Communications. 2022 Dec 29;13(1):7973.
6. Huang J#*, McLean GR, Dubee FC, Zheng Z. Two pandemics in China, One Health in Chinese. BMJ Global Health. 2022 Mar;7(3).
7. Huang J#*, Liang ZS, Pallotti S, Ranson JM, Llewellyn DJ, Zheng ZJ, King DA, Zhou Q, Zheng H, Napolioni V*. PAGEANT: personal access to genome and analysis of natural traits. Nucleic Acids Research.2022 Apr 22;50(7):e39.
8. Wang M, Huang J*, Wu T*, Qi L. Arterial Stiffness, Genetic Risk, and Type 2 Diabetes: A Prospective Cohort Study. Diabetes Care. 2022 Apr 1;45(4):957-964.
9. Huang J#, Liu J#, Tian R, Liu K, Zhuang P, Sherman HT, Budjan C, Fong M, Jeong MS, Kong XJ. A Next Generation Sequencing-Based Protocol for Screening of Variants of Concern in Autism Spectrum Disorder. Cells. 2021 Dec 21;11(1).
10. Huang J#*, Pallotti S, Zhou Q, Kleber M, Xin X, King DA, Napolioni V*. PERHAPS: Paired-End short Reads-based HAPlotyping from next-generation Sequencing data. Briefings in Bioinformatics. 2021 Jul 20;22(4).
11. You C, Zhou Z, Wen J, Li Y, Pang CH, Du H, Wang Z, Zhou XH, King DA, Liu CT, Huang J*. Polygenic Scores and Parental Predictors: An Adult Height Study Based on the United Kingdom Biobank and the Framingham Heart Study. Frontiers in Genetics. 2021;12:669441.
12. Du Y, Martin JS, McGee J, Yang Y, Liu EY, Sun Y, Geihs M, Kong X, Zhou EL, Li Y, Huang J*. A SNP panel and online tool for checking genotype concordance through comparing QR codes. PLoS One. 2017;12(9):e0182438.
13. Walter K#, Min JL#, Huang J#, Crooks L#, Memari Y, McCarthy S, Perry JR, Xu C, Futema M, Lawson D, Iotchkova V, Schiffels S, Hendricks AE, Danecek P, Li R, Floyd J, Wain LV, Barroso I, Humphries SE, Hurles ME, Zeggini E, Barrett JC, Plagnol V, Richards JB, Greenwood CM, Timpson NJ, Durbin R, Soranzo N. The UK10K project identifies rare variants in health and disease. Nature. 2015 Oct 1;526(7571):82-90.
14. Huang J#, Howie B, McCarthy S, Memari Y, Walter K, Min JL, Danecek P, Malerba G, Trabetti E, Zheng HF, Gambaro G, Richards JB, Durbin R, Timpson NJ, Marchini J, Soranzo N. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nature Communications. 2015 Sep 14;6:8111.
15. Huang J#, Huffman JE#, Yamakuchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégou?t DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, B?hm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA, Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP, Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, Marz W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O'Donnell CJ. Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). 2014 May;34(5):1093-101.
16. Huang J#, Liu EY, Welch R, Willer C, Hindorff LA, Li Y. WikiGWA: an open platform for collecting and using genome-wide association results. Eur J Hum Genet. 2013 Apr;21(4):471-3.
17. Huang J#, Sabater-Lleal M, Asselbergs FW, Tregouet D, Shin SY, Ding J, Baumert J, Oudot-Mellakh T, Folkersen L, Johnson AD, Smith NL, Williams SM, Ikram MA, Kleber ME, Becker DM, Truong V, Mychaleckyj JC, Tang W, Yang Q, Sennblad B, Moore JH, Williams FM, Dehghan A, Silbernagel G, Schrijvers EM, Smith S, Karakas M, Tofler GH, Silveira A, Navis GJ, Lohman K, Chen MH, Peters A, Goel A, Hopewell JC, Chambers JC, Saleheen D, Lundmark P, Psaty BM, Strawbridge RJ, Boehm BO, Carter AM, Meisinger C, Peden JF, Bis JC, McKnight B, ?hrvik J, Taylor K, Franzosi MG, Seedorf U, Collins R, Franco-Cereceda A, Syv?nen AC, Goodall AH, Yanek LR, Cushman M, Müller-Nurasyid M, Folsom AR, Basu S, Matijevic N, van Gilst WH, Kooner JS, Hofman A, Danesh J, Clarke R, Meigs JB, Kathiresan S, Reilly MP, Klopp N, Harris TB, Winkelmann BR, Grant PJ, Hillege HL, Watkins H, Spector TD, Becker LC, Tracy RP, M?rz W, Uitterlinden AG, Eriksson P, Cambien F, Morange PE, Koenig W, Soranzo N, van der Harst P, Liu Y, O'Donnell CJ, Hamsten A. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood. 2012 Dec 6;120(24):4873-81.
18. Huang J#, Ellinghaus D, Franke A, Howie B, Li Y. 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. Eur J Hum Genet. 2012 Jul;20(7):801-5.
19. Huang J#, Johnson AD, O'Donnell CJ. PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies. Bioinformatics. 2011 May 1;27(9):1201-6.
20. Huang J#, Perlis RH, Lee PH, Rush AJ, Fava M, Sachs GS, Lieberman J, Hamilton SP, Sullivan P, Sklar P, Purcell S, Smoller JW. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. American Journal of Psychiatry. 2010 Oct;167(10):1254-63.