師資
個(gè)人簡(jiǎn)介：
覃剛健，南方科技大學(xué)醫(yī)學(xué)院講席教授，博士生導(dǎo)師。畢業(yè)于武漢同濟(jì)醫(yī)科大學(xué)，獲醫(yī)學(xué)學(xué)士（1981-1986）和碩士（1986-1989）學(xué)位；畢業(yè)后留校附屬協(xié)和醫(yī)院兒科，歷任住院醫(yī)生、主治醫(yī)師和醫(yī)學(xué)講師（1989-1995）。后赴意大利國(guó)際遺傳工程和生物技術(shù)中心（1995–1998）和美國(guó)伊利諾伊大學(xué)芝加哥校區(qū)（1998–2001）接受博士后研究訓(xùn)練。此后，曾在波士頓塔夫茨大學(xué)圣伊麗莎白醫(yī)學(xué)中心任醫(yī)學(xué)講師、助理教授（2001–2006），芝加哥西北大學(xué)芬伯格醫(yī)學(xué)院心血管研究所、心內(nèi)科任助理教授、副教授（2007–2016），阿拉巴馬大學(xué)（伯明翰）任教授，分子心臟病學(xué)主任，生物醫(yī)學(xué)工程系副主任（2016–2022）。 覃教授多年來從事心血管系統(tǒng)發(fā)育、干細(xì)胞生物學(xué)、和缺血性心臟病的病理生理學(xué)研究，并致力于心肌和血管損傷的發(fā)生機(jī)理，以及組織保護(hù)、修復(fù)、和再生的治療策略探索。在該領(lǐng)域完成了一系列原創(chuàng)性工作并取得重要研究成果，包括揭示E2F家族轉(zhuǎn)錄因子在血管形成和血壓穩(wěn)態(tài)中的作用；分離鑒定獨(dú)特的心臟干細(xì)胞群；揭示CXCR4介導(dǎo)的骨髓干細(xì)胞微環(huán)境的信號(hào)機(jī)制，并建立內(nèi)源性干細(xì)胞在缺血組織修復(fù)中的重要性，以及氧化代謝在其分化中的關(guān)鍵作用；實(shí)現(xiàn)體內(nèi)示蹤和分離組織特異外泌體，并揭示缺血心肌外泌體的全身系統(tǒng)性作用；建立Sam68在能量穩(wěn)態(tài)、糖脂代謝、肥胖和2型糖尿病的重要調(diào)節(jié)作用。 覃教授在主流學(xué)術(shù)期刊上發(fā)表原創(chuàng)性論文130余篇，主持多項(xiàng)美國(guó)國(guó)立衛(wèi)生研究院（NIH）、心臟病協(xié)會(huì)（AHA）、和糖尿病協(xié)會(huì) (ADA) 項(xiàng)目。此外，覃教授還先后受聘為Circulation Research等10余種SCI期刊的編委，以及包括NIH、AHA、退伍軍人事務(wù)（VA）在內(nèi)的多個(gè)美國(guó)、和國(guó)際基金組織的評(píng)審委員或主持，并在美國(guó)心臟協(xié)會(huì)基礎(chǔ)學(xué)會(huì)（BCVS）、心血管放射學(xué)和干預(yù)委員會(huì)（CVRI）等專業(yè)協(xié)會(huì)擔(dān)任學(xué)術(shù)領(lǐng)導(dǎo)工作。在過去的18年里，覃教授成功培養(yǎng)了50多名不同職業(yè)階段的科研人員。
教育背景：
1981.09–1981.07 同濟(jì)醫(yī)科大學(xué)（現(xiàn)華中科技大學(xué)同濟(jì)醫(yī)學(xué)院）兒科系；獲醫(yī)學(xué)學(xué)士學(xué)位
1986.09–1989.12 同濟(jì)醫(yī)科大學(xué)兒科學(xué)新生兒專業(yè)；獲醫(yī)學(xué)碩士學(xué)位
工作經(jīng)歷：
1989.12–1992.08 住院醫(yī)生；同濟(jì)醫(yī)科大學(xué)附屬協(xié)和醫(yī)院兒科
1992.09–1995.10 主治醫(yī)師，醫(yī)學(xué)講師；同濟(jì)醫(yī)科大學(xué)附屬協(xié)和醫(yī)院兒科
1995.10–1998.08 博士后；意大利國(guó)際遺傳工程和生物技術(shù)中心，分子醫(yī)學(xué)組
1998.10–2001.04 博士后；美國(guó)伊利諾伊大學(xué)（芝加哥），血液/腫瘤科
2001.04–2004.08 醫(yī)學(xué)講師；美國(guó)塔夫茨大學(xué)附屬圣伊麗莎白醫(yī)學(xué)中心（波士頓），心血管科
2004.09–2006.12 助理教授；美國(guó)塔夫茨大學(xué)附屬圣伊麗莎白醫(yī)學(xué)中心（波士頓），心血管科
2007.01–2012.08 助理教授；美國(guó)西北大學(xué)芬伯格醫(yī)學(xué)院（芝加哥），心內(nèi)科，心血管研究所
2012.09–2016.06 副教授；美國(guó)西北大學(xué)芬伯格醫(yī)學(xué)院（芝加哥），心內(nèi)科，心血管研究所
2016.07–2022.09 教授，分子心臟病主任，生物醫(yī)學(xué)工程系副主任（自2017年11月）；美國(guó)阿拉巴馬州立大學(xué)醫(yī)學(xué)院，工程學(xué)院（伯明翰）
2022.09–至今 講席教授；南方科技大學(xué)醫(yī)學(xué)院（深圳）
獲獎(jiǎng)情況及榮譽(yù)：
2004 美國(guó)心臟協(xié)會(huì)Melvin Marcus 心血管科學(xué)青年研究員獎(jiǎng) (Melvin Marcus Young Investigator Award in Cardiovascular Sciences, Finalist)
2007 西北大學(xué)范伯格醫(yī)學(xué)院研究人員學(xué)術(shù)獎(jiǎng) (Investigators Developing Excellence in Academics Award)
2007 西北大學(xué)Searle教學(xué)獎(jiǎng) (Searle Fellow for Teaching Excellence)
2010 美國(guó)心臟協(xié)會(huì)榮譽(yù)會(huì)員（FAHA）
2018–2020 美國(guó)心血管卓越研究院 (ACRE)，主席
2022 深圳市鵬城特聘 （A類）
研究領(lǐng)域：
缺血損傷，器官保護(hù)與修復(fù)
心肌再生
干細(xì)胞與干細(xì)胞產(chǎn)品的治療轉(zhuǎn)化
糖脂和能量代謝
學(xué)術(shù)任職：
2016–2020 美國(guó)心臟協(xié)會(huì)基礎(chǔ)學(xué)會(huì) (BCVS)：會(huì)員與國(guó)際交流管理委員會(huì)
2017–2021美國(guó)心臟協(xié)會(huì)心血管放射學(xué)和介入委員會(huì) (CVRI): CVRI和PVD血管成像和介入委員會(huì)
2020–2023 美國(guó)心臟協(xié)會(huì)基礎(chǔ)學(xué)會(huì) (BCVS)：學(xué)術(shù)管理委員會(huì)
發(fā)表論文：
Representative publications (from a total of 130)
Zentilin L.*, Qin G.*, Tafuro S., Dinauer M.C., Baum C., and Giacca M. Variegation of retroviral vector gene expression in myeloid cells. Gene Ther 2000 Jan; 7(2):153-66. doi: 10.1038/sj.gt.3301057. PMID: 10673720
Qin G., Takenaka T., Telsch K., Kelley L., Howard T., Levade T., Deans R., Howard B.H., Malech H.L., Brady R.O., and Medin J.A. Preselective gene therapy for Fabry disease. Proc Natl Acad Sci U S A 2001 Mar 13; 98(6):3428-33. doi: 10.1073/pnas.061020598. PMID: 11248095 PMCID: PMC30670
Yoon Y.S., Wecker A., Heyd L., Park J.S., Tkebuchava T., Kusano K., Hanley A., Scadova H., Qin G., Cha D.H., Johnson K.L., Aikawa R., Asahara T., and Losordo D.W. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 2005 Feb 1; 115(2):326-38. doi: 10.1172/JCI22326 PMID: 15690083 PMCID: PMC546424
Kishore R., Qin G., Luedemann C., Bord E., Hanley A., Silver M., Gavin M., Yoon Y.S., Goukassian D., and Losordo D.W., The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. J Clin Invest 2005 Jun 16; 115(7):1785-96. doi: 10.1172/JCI22849 PMID: 15965500 PMCID: PMC1150283
Ii M., Nishimura H., Kusano K.F., Qin G., Yoon Y.S., Wecker A., Asahara T., and Losordo D.W., Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy. Circulation 2005 Jul 5; 112(1):93-102. doi: 10.1161/CIRCULATIONAHA.104.511964 PMID: 15983249
Qin G., Ii M., Silver M., Wecker A., Bord E., Ma H., Gavin M., Goukassian D.A., Yoon Y.S., Papayannopoulou T., Asahara T., Kearney M., Thorne T., Curry C., Eaton L., Heyd L., Dinesh D., Kishore R., Zhu Y., and Losordo D.W., Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med 2006 Jan 23; 203(1):153-63. DOI: 10.1084/jem.20050459. PMID: 16401693 PMCID: PMC2118065
Iwakura A., Shastry S., Luedemann C., Hamada H., Kawamoto A., Kishore R., Zhu Y., Qin G., Silver M., Thorne T., Eaton L., Masuda H., Asahara T., and Losordo D.W., Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 2006 Mar 28; 113(12):1605-14. doi: 10.1161/CIRCULATIONAHA.105.553925 PMID: 16534014
Qin G., Kishore R., Dolan C.M., Silver M., Wecker A., Luedemann C.N., Thorne T., Hanley A., Curry C., Heyd L., Dinesh D., Kearney M., Martelli F., Murayama T., Goukassian D.A., Zhu Y., and Losordo D.W., Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A 2006 Jul 18; 103(29):11015-20. doi: 10.1073/pnas.0509533103. PMID: 16835303 PMCID: PMC1544166
Hamada H., Kim M.K., Iwakura A., Ii M., Thorne T., Qin G., Asai J., Tsutsumi Y., Sekiguchi H., Silver M., Wecker A., Bord E., Zhu Y., Kishore R., and Losordo D.W., Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction. Circulation 2006 Nov 21; 114(21):2261-70. doi: 10.1161/CIRCULATIONAHA.106.631465. PMID: 17088460
Goukassian D.A., Qin G., Dolan C., Murayama T., Silver M., Curry C., Eaton E., Luedemann C., Ma H., Asahara T., Zak V., Mehta S., Burg A., Thorne T., Kishore R., and Losordo D.W., Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation 2007 Feb 13; 115(6):752-62. doi: 10.1161/CIRCULATIONAHA.106.647255. PMID: 17261656
Rajasingh J., Bord E., Hamada H., Lambers E., Qin G., Losordo D.W., and Kishore R., STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction. Circ Res 2007 Oct 26; 101(9):910-8. doi: 10.1161/CIRCRESAHA.107.156786. PMID: 17823373
Cho H.J., Lee N., Lee J.Y., Choi Y.J., Ii M., Wecker A., Jeong J.O., Curry C., Qin G., and Yoon Y.S., Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med 2007 Dec 24; 204(13):3257-69. doi: 10.1084/jem.20070166. PMID: 18070934 PMCID: PMC2150988
Rajasingh J., Lambers E., Hamada H., Bord E., Thorne T., Goukassian I., Krishnamurthy P., Rosen K.M., Ahluwalia D., Zhu Y., Qin G., Losordo D.W., and Kishore R., Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair. Circ Res 2008 Jun 6; 102(11):e107-17. doi: 10.1161/CIRCRESAHA.108.176115. PMID: 18483406 PMCID: PMC2435186
Krishnamurthy P., Rajasingh J., Lambers E., Qin G., Losordo D.W., and Kishore R. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res 2009 Jan 30; 104(2):e9-18. doi: 10.1161/CIRCRESAHA.108.188243. PMID: 19096025 PMCID: PMC2774810
Tang Y.L., Zhu W., Cheng M., Chen L., Zhang J., Sun T., Kishore R., Phillips M.I., Losordo D.W., and Qin G. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res 2009 May 22; 104(10):1209-16 (Editorial commended). doi: 10.1161/CIRCRESAHA.109.197723. PMCID: PMC2756190
Zhou J., Zhu Y., Cheng M., Dinesh D., Thorne T., Poh K.K., Liu D., Botros C., Tang Y.L., Reisdorph N., Kishore R., Losordo D.W., and Qin G., Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation 2009 Sep 29; 120(13):1213-21. doi: 10.1161/CIRCULATIONAHA.109.859207. PMCID: PMC2785027. (Editors pick)
Cheng M., Zhou J., Wu M., Boriboun C., Thorne T., Liu T., Xiang Z., Zeng Q., Tanaka T., Tang Y.L., Kishore R., Tomasson M.H., Miller R.J., Losordo D.W., and Qin G., CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 2010 Oct 29; 107(9):1083-93 doi: 10.1161/CIRCRESAHA.110.220970. PMID: 20847314 PMCID: PMC2966940 (Cover featured; Editors pick)
Sahoo S, Klyachko E, Thorne T, Misener S, Shinnick K, Millay M, Ito A, Liu T, Kamide C, Agarwal H, Perlman H, Qin G.,Kishore R, Losordo DW. Exosomes from Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity. Circ Res 2011 Sep 16; 109(7):724-8. doi: 10.1161/CIRCRESAHA.111.253286. PMID: 21835908. PMCID: PMC3201702
Krishnamurthy P., Thal M., Verma S.K., Hoxha E., Lambers E., Ramirez V., Qin G., Losordo D.W., and Raj Kishore. IL-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium. Circ Res 2011 Nov 11; 109(11):1280-9. doi: 10.1161/CIRCRESAHA.111.248369. PMID: 21959218 PMCID: PMC3235675
Thal MA, Krishnamurthy P, Mackie AR, Hoxha E, Lambers E, Verma S, Ramirez V, Qin G, Losordo DW, Kishore R. Enhanced Angiogenic and Cardiomyocyte Differentiation Capacity of Epigenetically Reprogrammed Mouse and Human Endothelial Progenitor Cells Augments their Efficacy for Ischemic Myocardial Repair. Circ Res 2012 Jul 6; 111(2):180-90. doi: 10.1161/CIRCRESAHA.112.270462. PMID: 22589373 PMCID: PMC3406600
Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh A, Kishore R. IL-10 Treatment Attenuates Pressure Overload-Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3-dependent Inhibition of Nulcear Factor-kB. Circulation 2012 Jul 24; 126(4):418-29. doi: 10.1161/CIRCULATIONAHA.112.112185. PMID: 22705886 PMCID: PMC3422741
Cheng M. and Qin G., Progenitor cell mobilization and recruitment: SDF-1, CXCR4, a4-integrin, and c-kit, Prog Mol Biol Transl Sci. 2012; 111:243-64. PMID: 22917234. DOI: 10.1016/B978-0-12-398459-3.00011-3 PMCID: PMC3556394 (Invited Review)
Jujo K, Ii M, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault M-A, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, MD, Losordo DW. CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia/Reperfusion Injury via Endothelial Nitric Oxide Synthase–Dependent Mechanism. Circulation 2013 Jan 1; 127(1):63-73. doi: 10.1161/CIRCULATIONAHA.112.099242. PMID: 23204107 PMCID: PMC3560409
Zhou J, Cheng M, Liao Y, Hu Y, Wu M, Wang Q, Qin B, Hong W, Zhu Y, Gao YM, Goukassian D, Zhao TC, Tang YL, Raj Kishore, Qin G. Rosuvastatin enhances angiogenesis via eNOS–dependent mobilization of endothelial progenitor cells PLoS ONE 2013 May 21; 8(5):e63126:1-7. doi: 10.1371/journal.pone.0063126. PMID: 23704894 PMCID: PMC3660394
Zhou J, Xu S, Cheng M, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in cardiac neovascularization PLoS ONE 2013 Jun 14; 8(6): e65755. doi:10.1371/journal.pone.0065755. PMID: 23799044 PMCID: PMC3683051
Zhou J, Cheng M, Wu M, Boriboun C, Jujo K, Xu S, Zhou TC, Tang YL, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis J Mol Cell Cardiol 2013 Jul; 60:68-71. doi: 10.1016/j.yjmcc.2013.04.009. PMID: 23603666 PMCID: PMC3684263
Renault MA, Vandierdonck S, Chapouly C, Yu Y, Qin G, Metras A, Couffinhal T, Losordo DW, Yao Q, Reynaud A, Jaspard-Vinassa B, Belloc I, Desgranges C, Gadeau AP. Gli3-regulation of myogenesis is necessary for ischemia-induced angiogenesis. Circ Res 2013 Oct 25; 113(10):1148-58. doi: 10.1161/CIRCRESAHA.113.301546. PMID: 24044950 PMCID: PMC4339272
Tongers J, Webber MJ, Vaughan EE, Sleep E, Renault M-A, Roncalli JG, Klyachko E, Thorne T, Yu Y, Marquardt K-T, Kamide CE, Ito A, Misener S, Millay M, Liu T, Jujo K, Qin G, Losordo DW, Stupp SI, Kishore R. Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrix, J Mol Cell Cardiol 2014 Sep; 74:231-9. doi: 10.1016/j.yjmcc.2014.05.017. PMID: 25009075 PMCID: PMC4135436
Wu M., Zhou J., Cheng M., Boriboun C., Biyashev D., Wang H., Mackie A., Thorne T., Cho J., Wu Y., Chen Z., Yan H., Kishore R., Taylor R.N., Losordo D.W., Qin G. E2F1 Suppresses Cardiac Neovascularization by Downregulating VEGF and PlGF Expression. Cardiovasc Res 2014 Dec 1; 104(3):412-22. doi: 10.1093/cvr/cvu222. PMID: 25341896. PMCID: PMC4296109
Cheng M, Huang K, Zhou J, Tang Y-L, Zhao TC, Miller RJ, Kishore R, Losordo DW, and Qin G. A Critical Role of Src Family Kinase in SDF-1/CXCR4-Mediated Bone-Marrow Progenitor Cell Recruitment to the Ischemic Heart. J Mol Cell Cardiol 2015 Apr; 81:49-53. doi: 10.1016/j.yjmcc.2015.01.024. PMID: 25655934 PMCID: PMC4380859
Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao T, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol 2015 Jun; 225:181-9. doi: 10.1530/JOE-14-0727. PMID: 25934704 PMCID: PMC4482239
Khan M, Nickoloff E, Abramova T, Johnson J, Verma SK, Krishnamurthy P, Mackie AR, Vaughan E, Garikipati VNS, Benedict C, Ramirez V, Lambers E, Ito A, Gao E, Misener S, Qin G, Houser SR, Koch WJ, Kishore R. Embryonic Stem Cell-derived Exosomes promote Endogenous Repair Mechanisms and Enhance Cardiac Function following Myocardial Infarction. Circ Res 2015 Jun 19; 117(1):52-64 doi: 10.1161/CIRCRESAHA.117.305990. PMID: 25904597 PMCID: PMC4482130
Wang Y, Zhang L, Li Y, Chen L, Zhang X, Guo W, Zhang X, Qin G, He SH, Zimmerman A, Liu Y, Kim IM, Weintraub NL, Tang Y-L. Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. Int’l J Cardiol 2015 Aug 1; 192:61-69. doi: 10.1016/j.ijcard.2015.05.020. PMID: 26000464 PMCID: PMC4469495
Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom JA, Kume T. Foxc1 regulates early cardiomyogenesis and functional properties of embryonic stem cell derived cardiomyocytes. Stem Cells 2016 Jun; 34(6):1487-500. doi: 10.1002/stem.2301. PMID: 26824887
Lizano P, Rashed E, Stoll S, Zhou N, Wen H, Hays TT, Qin G, Xie L-H, Depre C, Qiu H. The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo. Sci Rep 2017 Apr 20; 7:46324. doi: 10.1038/srep46324 PMID: 28425440 PMCID: PMC5397870
Arnone B, Chen JY, Qin G. Characterization and analysis of long noncoding rna (lncRNA) in In Vitro- and Ex Vivoderived cardiac progenitor cells. PLoS ONE 2017 Jun 22;12(6): e0180096. doi: 10.1371/journal.pone.0180096. PMID: 28640894 PMCID: PMC5481004
Wang H, Zhao YT, Zhang S, Dubielecka PM, Du J, Yano N, Chin YE, Zhuang S, Qin G, Zhao TC. Irisin Plays a Pivotal Role to Protect the Heart Against Ischemia and Reperfusion Injury. J Cell Physiol 2017 Dec; 232(12):3775-3785. doi: 10.1002/jcp.25857. PMID: 28181692 PMCID: PMC5550372
Xu S, Tao J, Yang L, Zhang E, Boriboun C, Zhou J, Sun T, Cheng M, Huang K, Dong N-G, Liu Q, Zhao TC, Qiu H, Harris RA, Chandel NS, Losordo DW, Qin G. E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells. Circ Res 2018 Mar 2; 122(5):701-11. doi: 10.1161/CIRCRESAHA.117.311814. PMID: 29358228 PMCID: PMC6021021
Zhu W, Zhang E, Zhao M, Chong Z, Fan C, Tang Y, Hunter JD, Borovjagin AV, Walcott GP, Chen JY, Qin G, and Zhang J. Regenerative Potential of Neonatal Porcine Hearts. Circulation 2018 Dec 11; 138(24):2809-2816. doi: 10.1161/CIRCULATIONAHA.118.034886. PMID: 30030418. PMCID: PMC6301098
Cheng M, Yang J, Zhao X, Zhang E, Zeng Q, Yu Y, Yang L, Wu B, Yi G, Mao X, Huang K, Dong N, Xie M, Limdi NA, Prabhu SD, Zhang J, and Qin G Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Commun 2019 Feb 27; 10(1):959 doi: 10.1038/s41467-019-08895-7. PMID: 30814518. PMCID: PMC6393447
Han S*, Xu Shiyue*, Zhou J, Qiao A, Boriboun C, Ma W, Li H, Diyashev D, Yang L, Zhang E, Liu Q, Jiang S, Zhao TC, Krishnamurthy P, Zhang C, Richard S, Qiu H, Zhang J, and Qin G. Sam68 impedes the recovery of arterial injury by augmenting inflammatory response. J Mol Cell Cardiol 2019 Dec; 137:82-92. doi: 10.1016/j.yjmcc.2019.10.003. PMID: 31639388 PMCID: PMC6889069
Berry JL, Zhu W, Tang Y, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang H-T, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res 2019 Jan 4; 124(1):161-169. PMID: 30605412. PMCID: PMC6350935 DOI: 10.1161/CIRCRESAHA.118.314216 (Invited Review)
Han D, Yang J, Zhang E, Liu Y, Boriboun C, Qiao A, Yu Y, Sun J, Xu S, Yang L, Yan W, Luo B, Lu D, Zhang C, Jie C, Mobley J, Zhang J, Qin G.. Analysis of mesenchymal stem cell proteome in situ in the infarcted heart. Theranostics 2020 Sep 14; 10(24):11324-38. doi: 10.7150/thno.47893. PMID: 33042285
Zhang E, Liu Y, Han C, Fan C, Wang L, Chen W, Du Y, Han D, Arnone B, Xu S, Wei Y, Mobley J, Qin G. Visualization and identification of bioorthogonally-labeled exosome proteins following systemic administration in mice. Front Cell Dev Biol 2021 Apr 7; 9:657456. doi: 10.3389/fcell.2021.657456. PMID: 33898459 PMCID: PMC8058422
Qiao A, Zhou J, Xu S, Ma W, Boriboun C, Kim T, Yan B, Deng J, Yang L, Zhang E, Song Y, Ma YC, Richard S, Zhang C, Qiu H, Habegger K, Zhang J, Qin G. Sam68 promotes hepatic gluconeogenesis via CRTC2. Nat Commun 2021 Jun 7; 12(1):3340. doi: 10.1038/s41467-021-23624-9. PMID: 34099657 PMCID: PMC8185084
Yang L, Deng J, Ma W, Qiao A, Xu S, Yu Y, Boriboun C, Kang X, Han D, Ernst P, Zhou L, Shi J, Zhang E, Li TS, Qiu H, Nakagawa S, Blackshaw S, Zhang J, Qin G. Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure. Theranostics 2021 Jul 6; 11(16):7995-8007. doi: 10.7150/thno.50990. PMID: 34335976 PMCID: PMC8315059
Qiao A, Ma W, Deng J, Zhou J, Han C, Zhang E, Boriboun C, Xu S, Zhang C, Jie C, Kim J, Habegger K, Qiu H, Zhao TC, Zhang J, Qin G. Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure FASEB J 2021 Aug; 35(8):e21772. doi: 10.1096/fj.202100021R. PMID: 34252225 PMCID: PMC8285032
Sun X, Zhou N, Ma B, Wu W, Stoll S, Lai L, Qin G, and Qiu H. Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model. Cells 2021 Oct 26; 10(11):2891. doi: 10.3390/cells10112891. PMID: 34831118 PMCID: PMC8616236
Patil M, Saheera S, Dubey PK, Kahn-Krell A, Govindappa PK, Singh S, Tousif S, Zhang Q, Lal H, Zhang J, Qin G, Krishnamurthy P. Novel mechanisms of exosome-mediated phagocytosis of dead cells in injured heart. Circ Res 2021 Nov 12; 129(11):1006-1020. doi: 10.1161/CIRCRESAHA.120.317900. PMID: 34623174 PMCID: PMC8595793
Qiao A, Ma W, Jiang Y, Han C, Yan B, Zhou J, Qin G. Hepatic Sam68 regulates systemic glucose homeostasis and insulin sensitivity. Int’l J Mol Sci 2022; 23(19): doi: 10.3390/ijms231911469. PMID:36232770
Han C, Yang J, Sun J, and Qin G. Extracellular Vesicles in Cardiovascular Disease: Biological Functions and Therapeutic Implications. Pharmacol Ther 2022 May; 233:108025. doi: 10.1016/j.pharmthera.2021.108025. PMID: 34687770 (Invited Review)
Han C and Qin G. Reporter systems for assessments of extracellular vesicle transfer. Front Cardiovasc Med 2022 Jun 1;9:922420. doi: 10.3389/fcvm.2022.922420. PMID: 35722089 PMCID: PMC9198260
Han C, Yang J, Zhang E, Jiang Y, Qiao A, Du Y, Zhang Q, An J, Sun J, Wang M, Nguyen T, Lal H, Krishnamurthy P, Zhang J, Qin G. Metabolic labeling of cardiomyocyte-derived small extracellular-vesicle (sEV) miRNAs identifies miR-208a in cardiac regulation of lung gene expression. J Extracell Vesicles 2022 Oct;11(10):e12246. doi: 10.1002/jev2.12246. PMID: 36250966 PMCID: PMC9575700