師資
個(gè)人簡介：
杜嘉木教授2003年本科畢業(yè)于復(fù)旦大學(xué)，2008年博士畢業(yè)于中科院上海生化細(xì)胞所，2009年赴美在紐約紀(jì)念斯隆凱特琳癌癥中心開始博士后研究；2014年回國，在中國科學(xué)院上海生命科學(xué)研究院植物逆境生物學(xué)研究中心組建獨(dú)立實(shí)驗(yàn)室，任研究員、課題組長、博士生導(dǎo)師；2019年2月調(diào)動(dòng)至南方科技大學(xué)生物系任教授、課題組長、博士生導(dǎo)師。2016年獲基金委優(yōu)秀青年科學(xué)基金的支持；2020年獲中國植物生理與植物分子生物學(xué)學(xué)會(huì)衛(wèi)志明青年創(chuàng)新獎(jiǎng)；2022年獲中國植物生理與植物分子生物學(xué)學(xué)會(huì)杰出青年科學(xué)家獎(jiǎng)；2023年獲基金委杰出青年科學(xué)基金支持。杜嘉木教授長期從事植物基因調(diào)控，特別是植物表觀遺傳調(diào)控的分子機(jī)制研究，在多個(gè)領(lǐng)域做出了杰出的貢獻(xiàn)，迄今共發(fā)表SCI論文67篇，其中多篇以通訊及共同通訊作者身份發(fā)表在Science、Nature Genetics、Nature Plants、Nature Chemical Biology、Nature Communications、Plant Cell、PNAS、J Integr Plant Biol等國際頂尖學(xué)術(shù)雜志上。
教育經(jīng)歷：
? 2003/09 – 2008/07，生物化學(xué)與分子生物學(xué)，博士
中國科學(xué)院上海生命科學(xué)研究院上海生物化學(xué)與細(xì)胞生物學(xué)研究所
（導(dǎo)師：丁建平研究員）
? 1999/09 –2003/07 生物學(xué)，學(xué)士 ，中國上海復(fù)旦大學(xué)
工作經(jīng)歷：
? 2019/02 – 至今，教授，南方科技大學(xué)生命科學(xué)學(xué)院生物系
? 2017/10 – 2019/01，青年研究骨干，中國科學(xué)院分子植物卓越創(chuàng)新研究中心；植物分子遺傳國家重點(diǎn)實(shí)驗(yàn)室
? 2014/09 – 2019/01，研究員，中國科學(xué)院上海生命科學(xué)研究院上海植物逆境生物學(xué)研究中心
? 2009/10 – 2014/08，博士后，紀(jì)念斯隆凱特琳癌癥中心（研究導(dǎo)師: Dinshaw J. Patel院士）
? 2008/07 – 2009/09，助理研究員，中國科學(xué)院上海生命科學(xué)研究院上海生物化學(xué)與細(xì)胞生物學(xué)研究所
榮譽(yù)及獎(jiǎng)勵(lì)：
? 2023年，國家自然科學(xué)基金委杰出青年科學(xué)基金
? 2022年，中國植物生理與植物分子生物學(xué)學(xué)會(huì)杰出青年科學(xué)家獎(jiǎng)
? 2022年，南方科技大學(xué)校長杰出科研獎(jiǎng)
? 2022年，南方科技大學(xué)優(yōu)秀研究生導(dǎo)師獎(jiǎng)
? 2020年，中國植物生理與植物分子生物學(xué)學(xué)會(huì)衛(wèi)志明青年創(chuàng)新獎(jiǎng)
? 2020年，中國科學(xué)院大學(xué)領(lǐng)雁銀獎(jiǎng)
? 2019年，中國科學(xué)院優(yōu)秀導(dǎo)師獎(jiǎng)
? 2018年，中國科學(xué)院優(yōu)秀導(dǎo)師獎(jiǎng)
? 2017年，國家自然科學(xué)基金委優(yōu)秀青年科學(xué)基金
? 2016年，科技部國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目首席科學(xué)家（青年）
雜志編輯
2018 – 至今，Biochemical Society Transactions，副編輯
雜志審稿人：
? Journal of Molecular Medicine ? PLoS One ? PNAS ? New Phytologist
? Trends in Plant Science ? Plant Cell ? Structure ? Molecular Plant
? Critical Reviews in Biochemistry & Molecular Biology ? Nature Communications
? Biochemistry and Biophysics Reports ?Journal of Molecular Biology
? Epigenetics & Chromatin
基金評(píng)審:
2018年，國家自然科學(xué)基金委青年項(xiàng)目、面上項(xiàng)目、地區(qū)科學(xué)基金項(xiàng)目
2017-2018年，中國博士后科學(xué)基金
代表文章：
(1) Xie, G#, Du, X#, Hu, H#, Li, S, Cao, X, Jacobsen, S.E, and Du, J. Structure and mechanism of the plant RNA polymerase V. Science. 2023, adf8231.
(2) Du X, Yang Z, Xie G, Wang C, Zhang L, Yan K, Yang M, Li S, Zhu JK, Du J. Molecular basis of the plant ROS1-mediated active DNA demethylation. Nat Plants. 2023, 9: 271-279.
(3) Zhang J#, Yuan J#, Lin J#, Chen L, You LY, Chen S, Peng L, Wang CH, Du J*, Duan CG*. Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants. Proc Natl Acad Sci U S A. 2023, 120: e2208525120.
(4) Leichter SM, Du J, Zhong X. Structure and Mechanism of Plant DNA Methyltransferases. Adv Exp Med Biol. 2022, 1389: 137-157.
(5) Zhou X#, Wei M#, Nie W#, Xi Y, Peng L, Zheng Q, Tang K, Satheesh V, Wang Y, Luo J, Du X, Liu R, Yang Z, La H, Zhong Y, Yang Y, Zhu JK, Du J*, Lei M*.The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis. J Integr Plant Biol. 2022, 64: 2385-2395.
(6) Du J*, Patel DJ*. Cofactor-assisted dicing: insights from structural snapshots. Cell Res. 2022 32: 965-966.
(7) Li S*, Du J*. Making a 6mA demethylase. Nat Chem Biol. 2022, 18: 683-684.
(8) Wang Q#, Xue Y#, Zhang L#, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris JC, Wu Z, Zhai J, Yang M, Li S*, Jacobsen SE*, Du J*. A SYBR Gold-based Label-free in vitro Dicing Assay. Bio Protoc. 2022, 12: e4382.
(9) Hu H, Du J*. Structure and mechanism of histone methylation dynamics in Arabidopsis. Curr Opin Plant Biol. 2022, 67:102211.
(10) Du X#, Yang Z#, Ariza AJF, Wang Q, Xie G, Li S, Du J*. Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell. 2022, 34: 2140-2149.
(11) Zeng X#, Lv X#, Liu R, He H, Liang S, Chen L, Zhang F, Chen L, He Y*, Du J*. Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation. J Integr Plant Biol. 2022, 64: 731-740.
(12) Wang Q#, Xue Y#, Zhang L#, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris CJ, Wu Z, Zhai J, Yang M, Li S*, Jacobsen SE*, Du J*. Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science. 2021, 374: 1152-1157
(13) Hu H#, Tian S#, Xie G, Liu R, Wang N, Li S, He Y*, Du J*. TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis. Proc Natl Acad Sci U S A. 2021, 118: e2103895118
(14) Wang Y#, Zhou X#, Luo J, Lv S, Liu R, Du X, Jia B, Yuan F, Zhang H, Du J*. Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2. J Integr Plant Biol. 2021, 63: 1091-1096.
(15) Niu Q#, Song Z#, Tang K, Chen L, Wang L, Ban T, Guo Z, Kim C, Zhang H, Duan CG, Zhang H, Zhu JK, Du J*, Lang Z*. A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation. Nat Commun. 2021, 12: 3367.
(16) Lv X, Zeng X, Hu H, Chen L, Zhang F, Liu R, Liu Y, Zhou X, Wang C, Wu Z, Kim C, He Y, Du J*. Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex. Plant Cell. 2021, 33: 1182-1195.
(17) Zhang YZ#, Yuan J#, Zhang L#, Chen C, Wang Y, Zhang G, Peng L, Xie SS, Jiang J, Zhu JK*, Du J*, Duan CG*.. Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis. Nat Commun. 2020, 11: 6212.
(18) Tan LM#, Liu R#, Gu BW, Zhang CJ, Luo J, Guo J, Wang Y, Chen L, Du X, Li S, Shao CR, Su YN, Cai XW, Lin RN, Li L, Chen S, Du J*, He XJ*. Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant Cell. 2020, 32: 2178-2195.
(19) Tao Z#, Hu H#, Luo X#, Jia B, Du J*, He Y*. Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants 2019, 5: 424-435.
(20) Zheng S, Hu H, Ren H, Yang Z, Qiu Q, Qi W, Liu X, Chen X, Cui X, Li S, Zhou B, Sun D*, Cao X*, Du J*. The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor. Nat Commun. 2019 10: 1303.
(21) Harris CJ#, Scheibe M#, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, Wang Z, Wohlschlegel JA, Du J, Rothbart SB, Butter F*, Jacobsen SE*. A DNA methylation reader complex that enhances gene transcription. Science 2018; 362: 1182-1186.
(22) Zhang C#, Du X#, Tang K#, Yang Z, Pan L, Zhu P, Luo J, Jiang Y, Zhang H, Wan H, Wang X, Wu F, Tao WA, He XJ, Zhang H, Bressan RA, Du J*, Zhu JK*. Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin. Nat Commun. 2018b; 9: 4547. (* co-corresponding authors)
(23) Li X#, Harris CJ#, Zhong Z, Chen W, Liu R, Jia B, Wang Z, Li S, Jacobsen SE*, Du J*. Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context biased non-CG DNA methylation. Proc Natl Acad Sci U S A. 2018; 115: E8793-E8802. (* co-corresponding authors)
(24) Yang Z#, Qian S#, Scheid RN, Lu L, Chen X, Liu R, Du X, Lv X, Boersma MD, Scalf M, Smith LM, Denu JM, Du J*, Zhong X*. EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat Genet. 2018; 50: 1247-1253. (* co-corresponding authors)
(25) Qian S#, Lv X#, Scheid RN#, Lu L, Yang Z, Chen W, Liu R, Boersma MD, Denu JM, Zhong X*, Du J*. Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nat Commun. 2018; 9: 2425. (* co-corresponding authors)
(26) Yang Z, Qiu Q, Chen W, Jia B, Chen X, Hu H, He K, Deng X, Li S, Tao WA, Cao X*, Du J*. Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases. Plant Cell. 2018; 30: 167-177. (* co-corresponding authors)
(27) Liu R#, Li X#, Chen W, Du J*. Structure and mechanism of plant histone mark readers. Sci China Life Sci. 2018; 61: 170-177. Review Article.
(28) Du J*. Structure and Mechanism of Plant DNA Methyltransferases. Adv Exp Med Biol. 2016; 945: 173-92. Book Chapter.
(29) Yuan W, Luo X, Li Z, Yang W, Wang Y, Liu R, Du J, He Y. A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis. Nat Genet. 2016; 48:1527-34
(30) Li S, Yang Z, Du X, Liu R, Wilkinson AW, Gozani O, Jacobsen SE, Patel DJ, Du J*. Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette. Structure. 2016; 24: 486-94
(31) Du J#, Johnson LM#, Jacobsen SE, Patel DJ. DNA methylation pathways and their crosstalk with histone methylation. Nat Rev Mol Cell Biol. 2015; 1839: 519-32. (# co-first authors) Review Article
(32) Du J*, Patel DJ*. Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks. Biochim Biophys Acta (Gene Regulatory Mechanisms). 2014; 1839:719-27. (* co-corresponding authors) Review Article
(33) Du J#, Johnson LM#, Groth M, Feng S, Hale CJ, Li S, Vashisht AA, Gallego-Bartolome J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol Cell. 2014; 55, 495–504. (# co-first authors)
(34) Zhong X#, Du J#, Hale CJ, Gallego-Bartolome J, Feng S, Vashisht AA, Chory J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell. 2014; 157: 1050-60. (# co-first authors)
(35) Johnson LM#, Du J#, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2014; 507: 124-8. (# co-first authors)
(36) Stroud H, Do T, Du J, Zhong X, Feng S, Johnson L, Patel DJ, Jacobsen SE. Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. Nat Struct Mol Biol. 2014; 21: 64-72.
(37) Law JA#, Du J#, Hale CJ#, Feng S, Krajewski K, Palanca AM, Strahl BD, Patel DJ, Jacobsen SE. Polymerase-IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature. 2013; 498: 385-89. (# co-first authors)
(38) Du J#, Zhong X#, Bernatavichute YV, Stroud H, Feng S, Caro E, Vashisht AA, Terragni J, Chin HG, Tu A, Hetzel J, Wohlschlegel JA, Pradhan S, Patel DJ, Jacobsen SE. Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell. 2012; 151:167-80. (# co-first authors)