師資
個人簡介
曹惠玲，南方科技大學醫(yī)學院生物化學系副教授(研究員），博導，國家優(yōu)青，深圳市海外高層次人才。
長期從事骨骼發(fā)育與穩(wěn)態(tài)調節(jié)及骨相關疾病研究。國際華人骨科研究協(xié)會（ICMRS）終身會員，國際華人骨科研究協(xié)會（ICMRS）青委會主席，中國免疫學會廣東省免疫學會血液免疫學專業(yè)委員會委員，中華醫(yī)學會骨科學分會第十一屆委員會創(chuàng)新與轉化學組青年委員會副組長，廣東省醫(yī)師協(xié)會運動損傷委員會基礎研究和醫(yī)工結合學組副組長。
擔任《Signal Transduction and Targeted Therapy 》、《Bone Research》、 《Aging Cell》、《Acta Pharmacol Sin》、《Cellular & Molecular Immunology 》、《Acta Pharmaceutica Sinica B 》、《Advanced Science》、《International Journal of Biological Sciences》等雜志審稿人 。國自然基金委函評（優(yōu)青、重點、面上等）、會評（面上、地方、青年、區(qū)域聯(lián)合重點等）專家。廣東省及湖南省杰青、優(yōu)青等項目評審專家。
主持或參與國家重點研發(fā)計劃、國自然重點項目、重大項目、優(yōu)秀青年基金項目、面上項目及青年基金、科技部重大專項、廣東省重點實驗室、深圳市科創(chuàng)委基礎研究項目等。
相關研究成果在《Journal of Clinical Investigation》、《Nature Communications》、 《Nature Aging》 、《Cell Reports Medicine》、《Protein & cell》、《Molecular Therapy》、《Signal Transduction and Targeted Therapy》、《Acta Pharmaceutica Sinica B》、《Diabetes》、《Bone Research》 、《Journal of Biological Chemistry》、《 JCI Insight》等國際一流雜志上發(fā)表文章40余篇，參編專著兩部，獲批發(fā)明專利6項。H指數(shù)=27。
此外，指導的博士生、碩士生多次獲得國家獎學金；指導的博士生獲得國自然博士生項目（青年學生基礎研究項目 (博士研究生)），博士后獲得國自然青年項目、博士后基金等。
研究領域
（1）研究生理病理條件下，骨骼發(fā)育及穩(wěn)態(tài)維持過程中調節(jié)成骨細胞、破骨細胞、軟骨細胞分化的機制；
（2）研究局部黏附蛋白（如 Kindlin-2、Migfilin、Pinch1/2）在骨骼發(fā)育與穩(wěn)態(tài)中的作用；
（3）糖、脂代謝的調節(jié)機制研究；
（4）骨-骨外組織、器官對話機制研究。
工作經(jīng)歷
2021/04- 至今 南方科技大學 醫(yī)學院 研究員
2020/03-2021/03 南方科技大學 醫(yī)學院 研究副教授（副研究員）
2017/01-2020/02 南方科技大學 生物系 研究副教授（副研究員）
2014/11-2016/12 南方科技大學 生物系 講師
2010/07-2011/08 美國匹茲堡大學 醫(yī)學院 博士后
學習經(jīng)歷
2004-09-2010-07 天津醫(yī)科大學-美國匹茲堡大學聯(lián)合培養(yǎng) 免疫學 博士
1999-09-2004-07 天津醫(yī)科大學 醫(yī)學檢驗 學士
所獲榮譽
2016 ASBMR Young Investigator Travel Grant, 2016 Plenary Poster，ASBMR 2016 Annual Meeting, September 16-19, 2016, Atlanta, Georgia, USA
2012 Chinese National Excellent Doctoral Dissertation nomination（2012 年全國優(yōu)秀博士學位論文提名論文）（Only 278 dissertations were nominated in 2012） “Activating transcription factor 4 regulates osteoclast differentiation in mice”, Chinese Ministry of Education, 2012
2012 Excellent Doctoral Dissertation Award （2012 年天津市優(yōu)秀博士學位論文） Tianjin city, China, 2012
2011 ASBMR Young Investigator Award, 2011（青年研究員獎） ASBMR (American Society for Bone and Mineral Research) annual meeting, 2011, San Diego, California, USA
2011 Young Investigator Award（青年研究員獎） 9th International Conference on Bone and Mineral Research (ICBMR) & 11th International Osteoporosis Symposium, 2011, Nanjing, China
2010 Excellent PhD Graduate Award（2010 年天津醫(yī)科大學優(yōu)秀博士畢業(yè)生） Tianjin medical university, China, 2010
學術成果
科研論文:
1. Yu S., Franceschi R.T., Luo M., Fan J., Jiang D., Cao H., Kwon T.G., Lai Y., Zhang J., Patrene K., Hankenson K., Roodman G.D., and Xiao G., Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. PLoS One, 2009. 4(10): p. e7583. PMCID: PMC2762317
2. Cao H.#, Yu S.#, Yao Z., Galson D.L., Jiang Y., Zhang X., Fan J., Lu B., Guan Y., Luo M., Lai Y., Zhu Y., Kurihara N., Patrene K., Roodman G.D., and Xiao G., Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest, 2010. 120(8): p. 2755-66. PMCID: PMC2912190
3. Yang S., Xu H., Yu S., Cao H., Fan J., Ge C., Fransceschi R.T., Dong H.H., and Xiao G., Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem, 2011. 286(21): p. 19149-58. PMID: 21471200.
4. Xiao G.#*, Cheng H.#, Cao H.#, Chen K., Tu Y., Yu S., Jiao H., Yang S., Im H.J., Chen D., Chen J.*, and Wu C.*, Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem, 2012. 287(25): p. 21450-60. PMID: 2255642.
5. Teramachi J., Hiruma Y., Ishizuka S., Ishizuka H., Brown J.P., Michou L., Cao H., Galson D.L., Subler M.A., Zhou H., Dempster D.W., Windle J.J., Roodman G.D., and Kurihara N., Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget’s disease. J Bone Miner Res, 2013. 28(6): p. 1489-50. PMID:23426901
6. Zhu K., Jiao H., Li S., Cao H., Galson D.L., Zhao Z., Zhao X., Lai Y., Fan J., Im H.J., Chen D., and Xiao G., ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res, 2013. 28(9): p. 1870-1884. PMID:23649506
7. Cao H., Zhu K., Qiu L., Li S., Niu H., Hao M., Yang S., Zhao Z., Lai Y., Anderson J.L., Fan J., Im H.J., Chen D., Roodman G.D., and Xiao G., Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. J Biol Chem, 2013. 288(42): p. 30399-410. PMID:24005670
8. Qin T.T., Xu G.C., Qi J.W., Yang G.L., Zhang K., Liu H.L., Xu L.X., Xiang R., Xiao G., Cao H., Wei Y., Zhang Q.Z., and Li L.Y., Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol, 237(3): p. 307-18. PMID: 26096340
9. Wu C. #*, Jiao H.#, Lai Y.#, Zheng W., Chen K., Qu H., Deng W., Song P., Zhu K., Cao H., Galson D.L., Fan J., Im H.J., Liu Y., Chen J., Chen D., and Xiao G.*, Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis. Nat Commun, 2015. 6: p. 7531. PMID: 26151572
10. Yang X., Xia R., Yue C., Zhai W., Du W., Yang Q., Cao H., Chen X., Obando D., Zhu Y., Chen X., Chen J.J., Piganelli J., Wipf P., Jiang Y., Xiao G., Wu C., Jiang J., and Lu B., ATF4 Regulates CD4(+) T Cell Immune Responses through Metabolic Reprogramming. Cell Rep, 23(6): p. 1754-1766. PMID:29742431
11. Xu H, Cao H, Xiao G. Signaling via PINCH: functions, binding partners and implications in human diseases. Gene. 2016 Aug 30. PMID: 27590440
12. 曹惠玲, 楊瑋，肖國芝 (2018): 軟骨細胞.《骨發(fā)育與骨疾病的現(xiàn)代研究》(書號：ISBN 978-7-313-20582-7, Book chapter)
13. Gao H.#, Guo Y.#, Yan Q.#, Yang W., Li R., Lin S., Bai X., Liu C., Chen D., Cao H.*, and Xiao G.*, Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2. JCI Insight, 2019. 4(13). PMID:31292295
14. Cao H#*, Xiao G* (2018): Kindlin Signaling and Bone. 《Encyclopedia of Bone Biology 》(Book chapter) by Dr. Mone Zaidi et al. Available online 29 July 2019. ISBN 978-0-12-814081-9. https://doi.org/10.1016/B978-0-12-801238-3.11176-6
15. Wang Y., Yan Q., Zhao Y., Liu X., Lin S., Zhang P., Ma L., Lai Y., Bai X., Liu C., Wu C., Feng J.Q., Chen D., Cao H.*, and Xiao G.*, Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight, 2019. 4(22). PMID: 31723057
16. Cao H.#*, Yan Q.#, Wang D.#, Lai Y., Zhou B., Zhang Q., Jin W., Lin S., Lei Y., Ma L., Guo Y., Wang Y., Wang Y., Bai X., Liu C., Feng J.Q., Wu C., Chen D., Cao X., and Xiao G.*, Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Research, 2020. 8(1): p. 2. PMID: 31934494.
17. Qin Lei, Liu Wen. Cao Huiling*, Xiao Guozhi*. Molecular mechanosensors in osteocytes. Bone Res. 8, 23 (2020, Jun). https://doi.org/10.1038/s41413-020-0099-y.
18. Zhu K., Lai Y., Cao H., Bai X., Liu C., Yan Q., Ma L., Chen D., Kanaporis G., Wang J., Li L., Cheng T., Wang Y., Wu C.*, and Xiao G.*, Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun, 2020. 11(1): p. 484. PMID: 31980627
19. Chen S., Qin L., Wu X., Fu X., Lin S., Chen D., Xiao G., Shao Z.*, and Cao H.*, Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells. Front Cell Dev Biol, 2020. 8: p. 127. PMID: 32195253
20. Yiming Lei#, Xuekun Fu#, Pengyu Li#, Sixiong Lin, Qinnan Yan, Yumei Lai, Xin Liu, Yishu Wang, Xiaochun Bai, Chuanju Liu, Di Chen, Huiling Cao*, Guozhi Xiao*. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Research, Oct 13, 2020, 8(37). DOI:1038/s41413-020-00108-y.
21. Fu X.#, Zhou B.#, Yan Q.#, Tao C., Qin L., Wu X., Lin S., Chen S., Lai Y., Zou X., Shao Z., Wang M., Chen D., Jin W., Song Y., Cao H.*, Zhang G.*, Xiao G.*-, Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduct Target Ther. Dec 26, 2020, 5(1). DOI: 1038/s41392-020-00328-y.
22. Qin L, He T, Chen S, Cao H*, Xiao G*. Role of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Bone Res. 9:44 (2021, Oct) https://doi.org/10.1038/s41413-021-00168-8
23. Lei Qin, Xuekun Fu, Jing Ma, Manxia Lin, Peijun Zhang, Yishu Wang, Qingnan Yan, Chu Tao, Wen Liu, Bing Tang, Di Chen, Xiaochun Bai*, Huiling Cao*, Guozhi Xiao*. Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. Communications Biology, Mar 25, 2021,4(1). DOI: 10.1038/s42003-021-01950-4.
24. Lei Qin, Dazhi Yang, Weihong Yi*, Huiling Cao*, Guozhi Xiao*. Roles of leader and follower cells in the collective cell migration. Mol Biol Cell, Jul 1, 2021, 32(14). DOI: 1091/mbc. E20-10-0681.
25. Huanqing Gao#, Yiming Zhong#, Zhen Ding#, Sixiong Lin#, Xiaoting Hou, Wanze Tang, Xiaoqian Zhou, Xuenong Zou, Jie Shao, Fan Yang, Xiaochun Bai, Chuanju Liu, Huiling Cao*, Guozhi Xiao*. Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice. Diabetes, 2021 Nov;70(11):2492-2505. doi: 10.2337/db21-0392
26. Sheng Chen, Mingjue Chen, Xiaohao Wu, Sixiong Lin, Chu Tao, Huiling Cao*, Zengwu Shao*, Guozhi Xiao*. Global, regional and national burden of low back pain 1990-2019: a systematic analysis of the Global Burden of Disease Study J Orthop Translat. 2022, Jan.
27. Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, Xiaochun Bai, Sheng Liu, Yongchao Wu, Huiling Cao*, Zengwu Shao*, Guozhi Xiao*. Kindlin-2 inhibits NLRP3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone Res., Jan 10, 2022, 10 (5). Doi: 10.1038/s41413-021-00179-5
28. Xiaohao Wu, Yumei Lai, Sheng Chen, Chunlei Zhou, Chu Tao, Xuekun Fu, Jun Li, Jian Huang, Wei Tong, Hongtao Tian, Zengwu Shao, Chuanju Liu, Di Chen, Xiaochun Bai*, Huiling Cao*, Guozhi Xiao*. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nature Aging, Feb 10, 2022. https://doi.org/10.1038/s43587-021-00165-w
29. Lei Qin1#, Nian Liu1#, Chaolemeng Bao2#, Dazhi Yang1, Guixing Ma3, Weihong Yi1*, Guozhi Xiao3*, Huiling Cao3*, Mesenchymal Stem Cells in Fibrotic Diseases – the two sides of the same coin. Acta Pharmacologica Sinica (2022) 0:1–20; https://doi.org/10.1038/s41401-022-00952-0
30. Sorour Sadeghzade, Jingyi Liu, Huiru Wang, Xin Li, Jinrui Cao, Huiling Cao, BinTang, Hongyan Yuan. Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review). Materials Today Bio, Oct 25, 2022. https://doi.org/10.1016/j.mtbio.2022.100473
31. Huanqing Gao1#, Liang Zhou2#, Yiming Zhong1#, Zhen Ding1#, Sixiong Lin1,3, Xiaoting Hou1, Xiaoqian Zhou4, Jie Shao5, Fan Yang5, Xuenong Zou3, Huiling Cao1*, Guozhi Xiao1*, Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice, Nat Commun, Feb 23, 13:1025 | https://doi.org/10.1038/s41467-022-28692-z.
32. Zhengwei Liu1#, Wanze Tang1#, Jiayi Liu2#, Yingying Han1, Qinnan Yan1, Yuechao Dong1, Xiaomei Liu1a, Dazhi Yang3, Guixing Ma1*, Huiling Cao1*, A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound. Bioact Mater, volume 20, February 2023, Pages 610-626. https://doi.org/10.1016/j.bioactmat.2022.06.008
33. Huanqing Gao#, Yiming Zhong#, Liang Zhou#, Sixiong Lin#, Xiaoting Hou#, Zhen Ding, Yan Li, Qing Yao, Huiling Cao, Xuenong Zou, Di Chen, Xiaochun Bai, Guozhi Xiao. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. 2023 Jan 9;12:e81792. doi: 10.7554/eLife.81792.
34. Wanze Tang1#, Zhen Ding1#, Huanqing Gao1#, Qinnan Yan1#, Jingping Liu2, Yingying Han1, Xiaoting Hou1, Zhengwei Liu1, Litong Chen1, Dazhi Yang1*, Guixing Ma1*, Huiling Cao1*, Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting Fas/PPARγ/Fabp4 signaling in mice. Acta Pharmaceutica Sinica B. Jul 07, 2023. https://doi.org/10.1016/j.apsb.2023.07.001.
35. Yuechao DONG1#, Yangshan CHEN1#, Guixing MA1, Huiling CAO1*. The role of E3 ubiquitin ligases in bone homeostasis and related diseases. Acta Pharmaceutica Sinica B. Jul 06, 2023. doi: 10.1016/j.apsb.2023.06.016.
36. Yuechao DONG1#, Xiaoting HOU1#, Yingying HAN1, Zhen DING1, Wanze TANG1, Yangshan CHEN1, Kaosheng Lv1, Guixing Ma1* and Huiling CAO1*. Kindlin-2 controls angiogenesis through modulating Notch1 signaling.Cell Mol Life Sci. October 2023. 13(10): 3963-3987. doi: 10.1016/j.apsb.2023.06.016.
37. Xiaoting Hou1#, Yangshan Chen1#, Bo Zhou1, Wanze Tang1,1a, Zhen Ding1, Litong Chen1, Wei Pang1, Yun Wu2, Hongyu Yang2, Changzheng Du1, Dazhi Yang1a, Guixing Ma1*, and Huiling Cao1*. Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice. Cell Death & Disease, Oct 31, 2023. 14 (10) Pages 709-723, DOI: 10.1038/s41419-023-06235-8.
38. Tailin He1#, Bo Zhou1#, Guohuan Sun2#, Qinnan Yan1, Sixiong Lin3, Guixing Ma1, Qing Yao1, Xiaohao Wu1, Yiming Zhong1, Donghao Gan1, Shaochuan Huo4, Wenfei Jin5, Di Chen6, Xiaochun Bai7*, Tao Cheng2*, Huiling Cao1*, Guozhi Xiao1*. The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway. Cell Death & Differentiation. 2023 Dec 07. doi: 1038/s41418-023-01243-9.
39. Yun Wu, Huan Jing, Yicun Li, Mengqing Li, yating Zheng, Yuntao Lin, Guixing Ma, Huiling Cao*, Hongyu Yang*. NOR1 promotes the osteoblastic differentiation of human periodontal ligament stem cells via TGF-β signaling pathway. Cell Mol Life Sci.2024 Aug 9;81(1):338.
40. Yong Chen, Botao Guo, Guixing Ma*, Huiling Cao*. Sensory nerve regulation of bone homeostasis: emerging therapeutic opportunities for bone-related diseases. Ageing Res Rev. 2024 Jun 14:102372. doi: 10.1016/j.arr.2024.102372.
41. Zhen Ding#, Guixing Ma#*, Bo Zhou, Siyuan Cheng, Wanze Tang, Yingying Han, Litong Chen, Wei Pang, Yangshan Chen, Dazhi Yang, Huiling Cao*. Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells. Cell Reports Medicine. 2024 Aug 20;5(8):101665.
42. Guixing Ma1#*, Yingying Han1#, Wanze Tang1a, Bo Zhou1, Litong Chen1, Zhen Ding1, Siyuan Cheng1, Di Chen2*, Huiling Cao1*.Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis.Protein & cell. 2024 Dec 2:pwae066. doi: 10.1093/procel/pwae066.
43. Guixing Ma#, Siyuan Cheng#, Yingying Han#, Wanze Tang, Wei Pang, Litong Chen, Zhen Ding, Huiling Cao1*.The p53-miR17 family-Rankl axis bridges liver-bone communication. Molecular Therapy.2024, 33 (2), 631-648.
44. Bo Zhou#, Hongwen Huang#, Zhen Ding#, Kaiwen Luo, Yangshan Chen, Yingying Han, Wei Pang, Wanze Tang, Litong Chen, Wenfei Jin*, Guixing Ma*, Huiling Cao*.Unveiling two distinct osteolineage cell populations linked to age-related osteoporosis in adult mice through integrative single-cell analyses. Cellular and Molecular Life Sciences. 2025, 82.106.
發(fā)明專利:
1. 專利號：ZL 2017 1 0180991.X，發(fā)明專利，名稱：Kindlin-2蛋白作為靶點在制備治療糖尿病的藥物中的應用，發(fā)明人：肖國芝，曹惠玲，授權日期：2020-04-28，公告（公開）日期：2017-09-01。
2. 專利號：ZL 2017 1 0169753.9，發(fā)明專利，名稱：Kindlin-2蛋白作為靶點在制備治療腎炎的藥物中的應用，發(fā)明人：肖國芝，曹惠玲，授權日期：2020-07-31，公告（公開）日期：2017-09-08。
3. 專利號：ZL 2017 1 0170718.9，發(fā)明專利，名稱：Kindlin-2蛋白作為靶點在制備治療骨性關節(jié)炎的藥物中的應用，發(fā)明人：肖國芝，曹惠玲，授權日期：2020-07-31，公告（公開）日期：2017-09-08。
4. 專利申請?zhí)枺?021101129689，發(fā)明專利，名稱：抑制肝細胞中Kindlin-2蛋白表達量的試劑在制備治療脂肪肝產品中的應用，發(fā)明人：肖國芝，曹惠玲，高煥慶，實審階段，申請日期：2021/1/27。
5. 專利申請?zhí)枺?02210513385.6，發(fā)明專利，名稱：一種水凝膠噴霧及其制備方法與應用，發(fā)明人：曹惠玲，馬貴興，劉正偉，實審，申請日期：2022/05/12。
6. 專利號：ZL 2022 1 1211629.1，Kindlin-2作為靶點在皮膚創(chuàng)傷修復中的應用，發(fā)明人：曹惠玲，馬貴興，申請日期：2022-09-30，授權公告日：2023-12-01。
7. 專利申請?zhí)枺?02210877899X，Kindlin-2作為靶點在治療骨質疏松及預防癌癥骨轉移中的應用，發(fā)明人：曹惠玲，馬貴興，實審階段，申請日期：2022/07/25。
8. 專利申請?zhí)枺?02310435009.4，抑制脂肪細胞中 Kindlin-2 蛋白表達的試劑在制備治療關節(jié)炎產品中的應用，發(fā)明人：曹惠玲，馬貴興，實審階段，公告（公開）日期：2023-07-21。
聯(lián)系方式
深圳市南山區(qū)西麗學苑大道1088號南方科技大學 慧園5棟205郵編：518055
電子郵件：[email protected]