Faculty
Self-introduction:
Dr. Meizhen Zheng obtained her Ph.D. degree from Sun Yat-Sen University Cancer Center in 2007. Then she achieved well-training in 3D genome mapping technology at Genome Institute of Singapore (GIS) and The Jackson Laboratory for Genomic Medicine (JGM) respectively since 2010. Dr. Zheng joined Southern University of Science and Technology (SUSTech) as an Assistant Professor in 2019 and focusing on the development of 3D genome mapping technology with single-molecule precision in single nuclei.
Research Interests：
◆ Multiplex chromatin interaction analysis with single-molecule precision in single nuclei.
◆ Genome-wide protein factor mediated RNA-chromatin DNA interaction analysis.
◆ The interested RNA mediated 3D genome architecture and the transcription regulation mechanism.
Professional Experience：
◆2019 - Currently Assistant Professor Southern University of Science and Technology
◆2017- 2019 Associated Research Scientist The Jackson Laboratory for Genomic Medicine
◆2012-2017 Postdoc The Jackson Laboratory for Genomic Medicine
◆2010-2012 Postdoc Genome Institute of Singapore
◆2007-2009 Postdoc Donghua University
Educational Background：
◆ 2007 obtained Ph.D. degree at Sun Yat-Sen University Cancer Center
◆ 2004 obtained Master degree at Jinan University
◆ 2001 graduated from Tongji Medical College, Huazhong University of Science and Technology
Selected Publication：
First author research papers:
◆ Meizhen Zheng, Simon Zhongyuan Tian, Daniel Capurso, Minji Kim, Rahul Maurya, Byoungkoo Lee, Emaly Piecuch, Liang Gong, Jacqueline Jufen Zhu, Zhihui Li, Chee Hong Wong, Chew Yee Ngan, Ping Wang, Xiaoan Ruan, Chia-Lin Wei & Yijun Ruan. Multiplex Chromatin Interaction Analysis with Single-Molecule Precision. Nature. 2019, 556:558-562.
◆ M.Z. Zheng, L.M. Zheng and Y.X. Zeng. SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase. J Cancer Res Clin Oncol. 2008 Apr; 134(4): 453-62.
◆ Meizhen Zheng, Haide Qin, Ruhua Zhang, Xingjuan Yu, Lizhen Chen, Qisheng Feng, Yixin Zeng. Haplotype of gene Nedd4 binding protein 2 associated with sporadic Nasopharyngeal carcinoma in the Southern Chinese population. J Transl Med. 2007 Jul 13; 5:36.
◆ Zheng, MZ; Jiang, JW. Progress in unmethylated immunostimulatory oligodeoxynucletides. Progress In Biochemistry And Biophysics. 2003,30(2):190-193.
Co-author research papers:
◆ The 4D nucleome project. The 4D Nucleome Network, Nature. 2017 Sep 13; 549(7671): 219–226.
◆ Xingwang Li,Oscar Junhong Luo,Ping Wang, Meizhen Zheng, Danjuan Wang, Emaly Piecuch, Jacqueline Jufen Zhu,Simon Zhongyuan Tian,Zhonghui Tang,Guoliang Li & Yijun Ruan. Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions. Nature Protocol. 2017,12:899-915.
◆ Zhonghui Tang, Oscar Junhong Luo, Xingwang Li, Meizhen Zheng, Jacqueline Jufen Zhu, Przemyslaw Szalaj, Pawel Trzaskoma, Adriana Magalska, Jakub Wlodarczyk, Blazej Ruszczycki, Paul Michalski, Emaly Piecuch, Ping Wang, Danjuan Wang, Simon Zhongyuan Tian, May Penrad-Mobayed, Laurent M Sachs, Xiaoan Ruan, Chia-Lin Wei, Edison T Liu, Grzegorz M Wilczynski, Dariusz Plewczynski, Guoliang Li, Yijun Ruan. CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell.2015, 163:1611-1627.
◆ Guoliang Li, X. Ruan, K. A. Raymond, K. S. Sandhu, Meizhen Zheng, Ping Wang, Huay Mei Poh, Yufen Goh, Joanne Lim, Jingyao Zhang, Hui Shan Sim, Su Qin Peh, Fabianus Hendriyan Mulawadi, Chin Thing Ong, Yuriy L. Orlov, Shuzhen Hong, Zhizhuo Zhang, Steve Landt, Debasish Raha, Ghia Euskirchen, Chia-Lin Wei, Weihong Ge, Huaien Wang, Carrie Davis, Katherine Fisher, Ali Mortazavi, Mark Gerstein, Thomas Gingeras, Barbara Wold, Yi Sun, Melissa J. Fullwood, Edwin Cheung, Edison Liu, Wing-Kin Sung, Michael Snyder, Yijun Ruan. Extensive Promoter-centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation. Cell. 2012 Jan 20;148 (1- 2):84-98.
◆ ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Sep 6; 489(7414): 57-74.
Patent：
◆ Compositions for RNA-chromatin interaction analysis and uses thereof. Yijun Ruan, Meizhen ZHENG, Junhong Oscar LUO. US Patent 9938565.
◆ Multiplex Chromatin Interaction Analysis with Single Molecule Precision. Meizhen ZHENG, Yijun Ruan, Simon Zhongyuan Tian, Chia-Lin Wei. US Patent Application number 16233860.
Other Info：
We are on the stage of initiating our lab and warmly welcome you to join us to build an active, creative and passionate team together for exploring the new 3D genome era! Join our lab and start our dream!