Faculty
BIOGRAPHY:
Zheng Zhang is a professor of the 2nd Affiliated Hospital, South University of Science and Technology and the Director of Institute for Hepatology at Shenzhen Third People’s Hospital, Guangdong, China. He received his doctoral degree (M.D. and PhD) in Immunology and the Infectious Diseases from Beijing Academy of Military Medical Sciences, Beijing, China. Then he received his postdoc training from University of North Carolina at Chapel Hill (UNC-CH). He has focused on clinical immunology, pathogenesis and immune therapy in pathogen chronic infection including SARS-CoV-2, HBV, HIV-1 and Tb. He obtained the grants from the National Grand Program on Key Infectious Disease, National Key Basic Research Program of China and National Science Fund for Distinguished Young Scholars as well as National Natural Science Foundation of China, et al. He has published more than 90 papers as first/corresponding authors in Nature, Cell, Nat Med, Cell Res, Nat Commun, Sci Adv, J Clin Invest, Gastroenterology, Blood, Hepatology and so on.
RESEARCH FIELD:
The immune mechanisms and immune interaction for chronic pathogen infection
RESEARCH PUBLICATIONS：
1. Ju B#, Zhang Q#, Ge S, Wang R, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Ge J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Wang X, Zhang Z*, Zhang L*. Potent human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 2020, 584(7819):115-119.
2. Zhang Q#, Ju B#, Ge J#, Chan JF#, Cheng L#, Wang R#, Huang W#, Fang M, Chen P, Zhou B, Song S, Shan S, Yan B, Zhang S, Ge X, Yu J, Zhao J, Wang H, Liu L, Lv Q, Fu L, Shi X, Yuen KY, Liu L, Wang Y*, Chen Z*, Zhang L*, Wang X*, Zhang Z*. Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Communications, 2021, 12:4210.
3. Bost P#, Giladi A#, Liu Y#, Bendjelal Y, Xu G, David E, Blecher-Gonen R, Cohen M, Medaglia C, Zhang S, Schwikowski B*, Zhang Z*, Amit I*. Host-viral infection maps reveal signatures of severe COVID-19 patients. Cell, 2020, 181(7):1475-1488.
4. Xu G#, Li Y#, Zhang S#, Peng H#, Wang Y#, Li D, Jin T, He Z, Tong Y, Qi C, Wu G, Dong K, Gou J, Liu Y, Xiao T, Qu J, Li L*, Liu L*, Zhao P*, Zhang Z*, Yuan J*. SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. Cell Res, 2021, 0:1–14; https://doi.org/10.1038/s41422-021-00578-7
5. Liao M#, Liu Y#, Yuan J#, Wen Y, Xu G, Zhao J, Cheng L, Li J, Wang X, Wang F, Liu L*, Ido A*, Zhang S*, Zhang Z*. Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19. Nat Med, 2020, 26(6):842-844.
6. Zhao J#, Yuan Q#, Wang H#, Liu W#, Liao X#, Su Y#, Wang X, Yuan J, Li T, Li J, Qian S, Hong C, Wang F, Liu Y, Wang Z, He Q, Li Z, He B, Zhang T, Ge S*, Liu L*, Zhang J*, Xia N, Zhang Z*. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin Infect Dis, 2020, 71(16):2027-2034.
7. Tang X, Zhang S, Peng Q, Ling L, Shi H, Liu Y, Cheng L, Xu L, Cheng L, Chakrabarti LA, Chen Z, Wang H, Zhang Z*. Sustained IFN-I Stimulation Impairs MAIT Cell Responses to Bacteria by Inducing IL-10 during chronic HIV-1 Infection. Sci Adv, 2020,6(8):eaaz0374.
8. Zhang Z#*, Cheng L#, Zhao J#, Li G, Zhang L, Chen W, Nie W, Reszka-Blanco N, Wang FS*, Su L*. Plasmacytoid dendritic cells promote HIV-1-induced group-3 innate lymphoid cell depletion. J Clin Invest, 2015, 125(9):3692–3703.
9. Zhang Z#, Zhang S#, Zou Z#, Shi J, Zhao J, Fan R, Qin E, Li B, Li Z, Xu X, Fu J, Zhang J, Gao B, Tian Z,Wang FS*. Hyper–Cytolytic Activity of Hepatic Natural Killer Cells Correlates with Liver Injury in Chronic Hepatitis B Patients. Hepatology, 2011, 53(1): 73-85.
10. Zhang Z#, Zhang JY#, Wherry EJ, Jin B, Xu B, Zou, ZS, Zhang SY, Li BS, Wang HF, Wu H, Fu YX, Wang FS. Dynamic programmed death-1 expression on virus-specific CD8 T cells correlates with the outcome of acute hepatitis B. Gastroenterology, 2008, 134: 1938-1949.