Faculty
SELF-INTRODUCTION：
I got my Ph.D from Northeast Normal University in 2013. My research interests focus on the molecular mechanism of tumor genesis and metastasis. EMT transcription factors (EMT-TFs) such as Snail1/Snail2, ZEB1/ZEB2, and Twist1/Twist2 have been shown to play a critical role in controlling EMT during embryogenesis and metastasis. Expression of EMT-TFs correlates with the tumor grade and nodal metastasis of many types of tumor and predicts a poor outcome in patients with metastatic cancer. We are employing biochemical, molecular, and cellular approaches to study the functional regulation of EMT-TFs in breast cancer and, by discovery dis-regulations, to identify molecules that may serve as the therapeutic targets for metastasis prevention.
EDUCATION:
2008-2013: Ph.D. in Cell Biology, School of Life Science, Northeast Normal University, Changchun, China;
2004-2008: B.Sc. in Biology, School of Life Science, LangFang Normal College, Langfang, China.
WOKRING EXPERIENCE:
2021.01-till now: Research Assistant Professor, Southern University of Science and Technology, School of medicine
2017.04-2020.12: Associate Investigator, Shenzhen University, Health Science Center;
2014.10-2017.04: Postdoctor/Assistant Investigator, Shenzhen Institutes of Advanced Technology;
2014.05-2014.09: Instructor, Xuzhou Medical College;
2013.09-2014.03: Visiting Fellow, National Cancer Insititute, Bethesda, USA;
HONORS AND AWARDS:
2017: The first prize of Science and Technology Award of Jilin Province (No. 4)
2015: Second prize of Natural Science Academic Achievements of Jilin Province (No. 4)
2015: Jilin province Excellent Doctoral Dissertation
2013: Doctoral scientific research first prize
2013: Excellent Graduated Graduate Student
2012-2013: Outstanding graduate student Scholarship, Northeast Normal University
2012-2013: Outstanding graduate student, Northeast Normal University
2012: Doctoral student National Scholarship, Ministry of Education
2011-2012: Outstanding graduate student Scholarship, Northeast Normal University
2009-2010: Outstanding graduate student Scholarship, Northeast Normal University
Research:
Molecular mechanism of tumor metastasis
PUBLICATIONS：
(1) Jianchao Zhang, Xinxin Lin, Liufeng Wu, Jia-Jia Huang, Wen-qi Jiang, Thomas Kipps, and Suping Zhang, Aurora B induces epithelial–mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis. Oncogene, 2020, 39(12):2550-2567.
(2) Jianchao Zhang, Ximing Shao, Haiyan Sun, Ke Liu, Zhihao Ding, Juntao Chen, Lijing Fang, Wu Su, Yang Hong, Huashun Li and Hongchang Li, NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget, 2016, 7(38):61036-53.
(3) Jianchao Zhang, Qian Liang, Yang Lei, Min Yao, Lili Li, Xiaoge Gao, Jingxin Feng, Yu Zhang, Hongwen Gao, Dong-Xu Liu, Jun Lu, and Baiqu Huang, SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. Cancer Research, 2012, 72(17):4597-608.
(4) Jianchao Zhang, Yang Lei, Xiaoge Gao, Qian Liang, Lili Li, Jingxin Feng, Yu Zhang, Baiqu Huang, and Jun Lu, p53 attenuates the oncogenic ras-induced epithelial-mesenchymal transition in human mammary epithelial cells. Biochemical and Biophysical Research Communications, 2013, 434(3):606-13.
(5) Suping Zhang, Han Zhang, Emanuela M. Ghia, Jiajia Huang, Liufeng Wu, Jianchao Zhang, Sharon Lam, Yang Lei, Jinsong He, Bing Cui, George F. Widhopf II, Jian Yu, Richard Schwab, Karen Messer, Wenqi Jiang, Barbara A. Parker, Dennis A. Carson, and Thomas J. Kipps, Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. Proc Natl Acad Sci U S A, 2019, 116(4):1370-1377.
(6) Ximing Shao, Yi Liu, Qian Yu, Zhihao Ding, Wenyu Qian, Lei Zhang, Jianchao Zhang, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang Li and Huashun Li, Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Research, 2016, 26(5):593-612.
(7) Qian Liang, Lili Li, Jianchao Zhang, Yang Lei, Liping Wang, Dong-Xu Liu, Jingxin Feng, Pingfu Hou, Ruosi Yao, Yu Zhang, Baiqu Huang, and Jun Lu, CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Scientific Reports. 2013, 14;3:2932.
(8) Jingxin Feng, Guiying Xu, Jiwei Liu, Na Zhang, Lili Li, Jiafei Ji, Jianchao Zhang, Lian Zhang, Guannan Wang, Xiuli Wang, Jiang Tan, Baiqu Huang, Jun Lu, Yu Zhang, Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer. Breast Cancer Research and Treatment. 2016, 159(3):443-56.
(9) Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei Wu, Xiaoqi Liu, Huashun Li, Rui Wang, Wu Su, and Hongchang Li, Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo. Molecular Cancer Therapeutics, 2018, 17(5):988-1002.
(10) Ke Liu, Run Lei, Qiong Li, Xin-Xin Wang, Qian Wu, Peng An, Jianchao Zhang, Minyan Zhu, Zhiheng Xu, Yang Hong, Fudi Wang, Ying Shen, Hongchang Li, and Huashun Li, Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Scientific Reports. 2016, 16;6:21019.
(11) Ke Liu, Quan Lin, Yanxia Wei, Renbing He, Ximing Shao, Zhihao Ding, Jianchao Zhang, Minyan Zhu, Lee S. Weinstein, Yang Hong, Hongchang Li, Huashun Li, Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neuroscience Letters. 2015, 597:97-103.
(12) Yu Zhang, Yanyan Gao, Guoping Zhang, Shuyan Huang, Zhixiong Dong, Chenfei Kong, Dongmei Su, Juan Du, Shan Zhu, Qian Liang, Jianchao Zhang, Jun Lu and Baiqu Huang, DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. International Journal of Cancer, 2011, 128:551-61.
(13) Dongmei Su, Xiue Peng, Shan Zhu, Ying Huang, Zhixiong Dong, Yu Zhang, Jianchao Zhang, Qian Liang, Jun Lu, Baiqu Huang, Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung cancer cells. Biochemical Journal, 2010, 433(2):333-43.
(14) Hanqing Shi, Hui Huang, Xitao Zhang, Jianchao Zhang, Xiutan Luo, Xiue Peng, Baiqu Huang, Jun Lu, c-Myc attenuates the ability of doxorubicin to reduce the colony formation partially through regulating Nbs1 in U2OS cells. Progress in Biochemistry and Biophysics, 2010, 37(8):855-63.