Faculty
SELF-INTRODUCTION：
Wang, Ying is now an Assistant Professor in the School of Medicine at SUSTech from 2022. Prior to joining to SUSTech, she was a postdoctoral research fellow at the University of California, Davis working on cardiac physiology and pathology using genetically encoded FRET-based biosensors, optical imaging and transgenetic mouse models. She completed her Bachelor in Pharmaceutical Engineering degree in Guizhou University (2008-2012) and Ph.D in Cardiovascular Pharmacology in the Fudan University (2012-2016). Over the years, Ying's work has led to a great track record of SCI publications, including the high-impact journal like Circulation Research (3 of 10, 2 first author, 1 middle author), and a patent. Additionally, she was awarded American heart association (AHA) Postdoctoral Fellowship (USD $140,752.00), multiple academic travel, presentation awards and a prestigious Chinese grant (2022). Ying is now serving as a reviewer editor and guest editor for several journals, including Advanced Science, Cells etc.
EDUCATION:
2008.09-2012.06 B.S in Pharmaceutical Engineering, Guizhou University
2012.09-2017.06 Ph.D. in Cardiovascular Pharmacology, Fudan University
WOKRING EXPERIENCE:
2017.10-2022.9 University of California at Davis, Postdoctoral Fellow
2022.9- 2022.11 Southern University of Science and Technology，Assistant Professor
2022.12- present Southern University of Science and Technology，Associate Professor
HONORS AND AWARDS:
2012 Outstanding Undergraduate Scholarship of Guizhou Province, China
2012 Doctoral Freshman Scholarship, Fudan University, China
2013 Cross-Disciplinary Outstanding Predoctoral Research Award, Fudan University, China
2014 Research Paper Award, 9th PharmSci@Asia Symposium, Shanghai
2015 Shanghai Pharmacology Youth Symposium, Outstanding Paper Award
2015 First Prize, Yangzte River Delta Bioscience and Human Health 2015 Conference, Wuhu, China
2016 Tony B. Academic Travel Award, SLAS 5th Annual Conference and Exhibition, San Diego, USA
2016 Graduate Scholarship, Fudan University
2017 Tony B. Academic Travel Award, SLAS 2017, 6th Annual Conference and Exhibition, Washington
2021 American Heart Association (AHA) Postdoctoral Fellowship Award
2022 Poster Competition Award, IX ACRE-APS symposium, 2022 AHA BCVS session, Chicago
2022 American Heart Association (AHA) New Investigator Travel Award
Research:
My lab focuses on the spatial compartmentalization and heterogeneity of GPCR signaling in cardiac physiology and pathology. I aim to define patient-specific therapeutic strategies for heart diseases targeting the spatiotemporal regulation of GPCR signaling and Ca2+ in diverse cardiac pathogenesis (e.g., heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, inflammation, etc.) and to provide innovative therapeutic strategies for cardiac diseases treatment. My current research topics include:
1、Targeting GPCR signaling nanodomains to regulate cardiac excitation-contraction coupling）
2、Ca2+ dysregulation in heart failure progression and arrhythmogenesis
3、Polypharmacology in the cardiovascular system
MANUSCRIPT REVIEWER AND EDITOR：
2022- Advanced Science (Guest reviewer)
2022- Frontiers in Immunology (Guest reviewer and topic coordinator)
2022- Cells, Guest editor
2022- American Heart Association (AHA) grant reviewer-in-training
2021- Frontiers in Microbiology (Guest reviewer)
2023 - British Journal of Pharmacology（reviewer）
PUBLICATIONS：
1. Xiang W, Lu H, Shen A, Ni H, Wang Y. Nuclear β-adrenergic signaling microdomain alleviates diabetic kidney fibrosis by YAP inactivation. British Journal of Pharmacology (In revision).
2. Wang Y, Zhao M, Liu XH, Xu B, Rivera G, Xiang YK. Nitric oxide synthase isoforms dictate a biased and compartmentalized adrenergic signaling to promote cardiac contractility. (In Revision. JACC: Basic to Translational Science (In revision).
3. Fu Q, Wang Y, Yan C, Xiang YK. Phosphodiesterases in heart and vessels- From Physiology to Diseases. Physiol Rev. 2023.
4. Bing Xu, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yu Zhang, Bingqing Deng, Zhenduo Zhu; Qiuyun Guan, Nipavan Chiamvimonvat, Qingtong Wang, and Yang K. Xiang. HFrEF and HFpEF model-specific remodeling of subcellular PKA signaling at the ryanodine receptors and SERCA2a. Journal of the American Heart Association (In revision).
5. Wenjing Xiang1*, Xingyun Wang1*, Lei Li1, Junhui Zeng1, Haocheng Lu1&, Ying Wang1&, Unveiling Catecholamine Dynamics in Cardiac Health and Disease: Mechanisms, Implications, and Future Perspectives. International Journal of Drug Discovery and Pharmacology 2023.
6. Xiang W, Zhou N, Li L, Chen F, Li L, Wang Y. βIV-Spectrin in Cardiac Fibroblasts: Implications for Fibrosis and Therapeutic Targeting in Cardiac Diseases. Comment on Nassal et al. Spectrin-Based Regulation of Cardiac Fibroblast Cell-Cell Communication. Cells 2023, 12, 748. Cells. 2023;12:2186.
7. Deng B, Zhang Y, Zhu C, Wang Y, Weatherford E, Xu B, Liu X, Conway SJ, Abel ED, Xiang YK. Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling. Circ Res. 2023;132:106–108.
8. Xiang W, Zhou N, Li L, Chen F, Li L, Wang Y. βIV-Spectrin in Cardiac Fibroblasts: Implications for Fibrosis and Therapeutic Targeting in Cardiac Diseases. Comment on Nassal et al. Spectrin-Based Regulation of Cardiac Fibroblast Cell-Cell Communication. Cells 2023, 12, 748. Cells. 2023;12:2186.
9. Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK. Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022;117:37.
10. Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK. Monoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure. Circ Res. 129 (10), 965-967.
11. Wang Y*, Shi Q*, Li M, Zhao M, Reddy GR, Teoh JP, Xu B, Zhu CQ, Ireton KE, Srinivasan S, Chen SL, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. Intracellular β1-Adrenergic eceptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2020 Nov; DOI: 10.1161/CIRCRESAHA.120.317452.
12. Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK. Carvedilol induces biased β1 adrenergic receptor-Nitric oxide synthase 3-cyclic guanylyl monophosphate signaling to promote cardiac contractility. Cardiovasc Res. 2020 Sep 21; doi: 10.1093/cvr/cvaa266.
13. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. GRK5 Controls SAP97-Dependent Cardiotoxic β1 adrenergic receptor-CaMKII signaling in heart failure. Circ Res. 2020 Aug 28;127(6):796-810. doi: 10.1161/CIRCRESAHA.119.316319.
14. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 Nov 5;150(11):1567-1582. doi: 10.1085/jgp.201812119.
15. Wang Y, Cao Y, Zhu Q, Gu X, Zhu YZ. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification. Sci Rep. 2016 Jul 22;6:29820.
16. Wang Y, Zhong L, Liu X, Zhu YZ. ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing nox4-derived ROS production and apoptosis. Molecules. 2017 Feb 21;22(2). doi: 10.3390/molecules22020331.
17. Wang Y, Zhang Q, Zhong L, Lin M, Luo X, Liu S, Xu P, Liu X, Zhu YZ. Apoptotic Protease activating factor-1 inhibitor mitigates myocardial ischemia injury via disturbing procaspase-9 recruitment by Apaf-1. Oxid Med Cell Longev. 2017;2017:9747296.
18. Zhang QY, Wang ZJ, Miao L, Wang Y, Chang LL, Guo W, Zhu YZ. Neuroprotective Effect of SCM-198 through stabilizing endothelial cell function. Oxid Med Cell Longev. 2019;2019:7850154.
19. Zhang QY, Wang ZJ, Sun DM, Wang Y, Xu P, Wu WJ, Liu XH, Zhu YZ. Novel Therapeutic effects of leonurine on ischemic stroke: New Mechanisms of BBB Integrity. Oxid Med Cell Longev. 2017;2017:7150376.
20. Xu B, Wang Y, Bahriz SMFM, Zhao M, Zhu C, Xiang YK. Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes. Cell Commun Signal. 2022 Sep 14;20(1):143.