Faculty
Angela Qing Yao, who was born in Wuhan China, earned her Ph.D. degree in the Faculty of Medicine at the University of Hong Kong. She then went to Ann Arbor in U.S. and did her postdoctoral training in the School of Medicine at University of Michigan. Her research interests focus on skeletal development and diseases. She has perticular interests in cartilage development and chondrocyte metabolism; the role and mechanisms of hypoxia and Hypoxia Inducible factors (HIFs) in skeletal development; the metabolism of articular chondrocytes in osteoarthritis; the interplay between ER stress and hypoxia stress in chondrocytes. In recent 5 years, she has published her research articles in Developmental Cell, Bone Research etc. She was invited to give oral presentations of her work in ASBMR (American Society for Bone and Mineral Research) and The Frederick J. Fisher Pediatric Orthopaedic Lectureship and won the 2017 ASBMR Young Investigator Award.
EDUCATION:
Sep./2010-Feb./2015 Ph.D. The University of Hong Kong, Faculty of Medicine
Sep./2006-Jun./2009 M.Sc. Sun Yat-Sen University, School of Life Science
Sep./2002-Jun./2006 B.Sc. Central China Normal University, School of Life Science
B.A. School of Linguistics
WOKRING EXPERIENCE:
May/2015-Oct./2017 Orthopaedic Surgery Department, School of Medicine, University of Michigan, USA Postdoctoral Research Fellow
Jul./2009 -Aug./2010 Biotechnology Research Center, Sun Yat-Sen University Research Assistant of the Director
HONORS AND AWARDS:
Sep./2017 Young Investigator Award The American Society for Bone and Mineral Research (ASBMR)
GRANTS:
Oct./2016-Oct./2017 Focused Research Grant
Supported by Orthopaedic Surgery Department, School of Medicine, University of Michigan
09/2020-08/2022 Shenzhen science and technology innovations Committee General Project，Amounts：500,000.00RMB
Title：Study on the changes of metabolic programming of articular chondrocytes at early stage of post-traumatic osteoarthritis
01/2022-12/2025 NSFC General Project, Amounts：530,000.00RMB
Title：Role and mechanism of mitochondrial transcription factor A (TFAM) in regulating chondrocyte energy metabolism and terminal differentiation
MANUSCRIPT REVIEWER AND EDITOR：
Jun/2016 – present Medicine? Reviewer and Academic EditorJun/2018 - present Aging Reviewer
PUBLICATIONS：
1. Yao Q., Parvez Khan M, Schipani E. “In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes.” Bone, 2020, 140（115572）
2. Yao, Q., Parvez Khan M, Merceron C, LaGory E, Tata Z, Mangiavini L, Hu J, Vemulapalli K, Chandel NS, Giaccia AJ, Schipani E. “Suppressing mitochondrial respiration is critical for hypoxia tolerance in the fetal growth plate.” (2019) Developmental Cell,49:748-763 (Preview in the same issue of Developmental Cell; featured in the Editor’s Choice of Science Signaling 2019;12)
3. Merceron, C., Ranganathan, K., Wang, E., Tata, Z., Makkapati, S., Khan, M. P., Mangiavini, L., Yao, A. Q., Castellini, L., Levi, B., Giaccia, A. J., Schipani, E. “Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual.” (2019) Bone research, 7:7
4. Kudelko M., Chan C.W., Sharma R., Yao Q., Lau, E., Chu, I.K., Cheah, K.S.E., Tanner, J.A. and Chan, D. "Label-Free Quantitative Proteomics Reveals Survival Mechanisms developed by hypertrophic chondrocytes under ER stress." (2016) J.Proteome Res. 15(1):86-99
5. Pineault KM., Swinehart IT.,Garthus KN., Ho E., Yao Q., Schipani E., Kozloff KM.,Wellik DM. "Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation." (2015) Biol Open, 4(11),1538-1548
6. Zhang, Q. Q., H. Xu, M. B. Huang, L. M. Ma, Q. J. Huang, Yao, Q., H. Zhou, and L. H. Qu. "Microrna-195 Plays a Tumor-Suppressor Role in Human Glioblastoma Cells by Targeting Signaling Pathways Involved in Cellular Proliferation and Invasion." Neuro Oncol 14, no. 3 (2012): 278-87.
7. Yao, Q., H. Xu, Q. Q. Zhang, H. Zhou, and L. H. Qu. "Microrna-21 Promotes Cell Proliferation and Down-Regulates the Expression of Programmed Cell Death 4 (Pdcd4) in Hela Cervical Carcinoma Cells." Biochem Biophys Res Commun 388, no. 3 (2009): 539-42.
8. Zhang R, Yao Q, Peng JX, Hong HZ, (2006) “The Structure, Function and Evolution of Baculoviral Inhibitor of Apoptosis Gene.” Microbiology China. 0253-2654 (2006) 01-0128-05
9. Li JJ, Yao Q, Yang DY, Yu ZH, Chen XW, (2005) “Cloning and Expression of Ubiquitin Gene of Helicoverpa armigera Single-nucleocapsid Nucleopolyhedrovirus and its Antiserum Preparation.” Virologica Sinica. 20 (3): 298-302