Faculty
Self-introduction
Dr. Yang SU is a Research Assistant Professor at School of Life Sciences, Southern University of Science and Technology. He did his Bachelor's at Jiangsu Ocean University and obtained a Ph.D. degree in biology at Nanjing Normal University. Then he moved to Shanghai Jiaotong University and Southern University of Science and Technology for post-doctorial studies. He is now interested in the functions of inositol phosphates and metabolic regulations of protein homeostasis. Dr. Su is supported by grants from the National Natural Science Foundation of China, the Department of Science and Technology of Guangdong Province, and the Shenzhen Science and Technology Innovation Commission. He has published several research papers in journals like Molecular Cell, mbio, and FEBS Journal as first or co-first authors.
Research Interests：
◆The Cullin-Ring ligases are the largest family of E3 enzymes that mediate 20% of proteasomal degradation. CRLs require neddylation, for optimal function and are tightly regulated by CSN deneddylase complex. Our group recently discovered a role for the glucose in assembling and disassembling CRL-CSN complexes. How such metabolite-dependent CRL regulation integrates into cellular physiology, is the emphasis.
Professional Experience：
◆ 2021.11~ Present, Research Assistant Professor, Department of neurobiology, SUSTech
◆ 2018.12~2021.07, Postdoctoral Fellow, Department of neurobiology, SUSTech
◆ 2016.07~2018.09, Postdoctoral Fellow, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine
Educational Background：
◆ 2011.09~2016.06 Ph. D., College of Life Sciences, Nanjing Normal University
◆ 2007.09~2011.06 Bachelor., College of Oceanography, Jiangsu Ocean University
Selected Publication：
◆ Yang Su(#), Yifan Luo(#), Peitao Zhang, Hong Lin, Weijie Pu, Hongyun Zhang, Huifang Wang, Yi Hao, Yihang Xiao, Xiaozhe Zhang, Xiayun Wei, Siyue Nie, Keren Zhang, Qiuyu Fu, Hao Chen, Niu Huang, Yan Ren, Mingxuan Wu, Billy Kwok Chong Chow, Xing Chen, Wenfei Jin, Fengchao Wang*, Li Zhao*, Feng Rao*, Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis, Molecular Cell, 2023 Jun 6;83(13):2316-2331.
◆ Yang Su(#), Jianhui Li(#), Wenting Zhang(#) , Jinjing Ni, Rui Huang, Zuoqiang Wang, Sen Cheng, Yue Wang, Zhixin Tian, Qiuxiang Zhou, Donghai Lin, Wenjuan Wu, Christoph M. Tang, Xiaoyun Liu*, Jie Lu*, Yu-Feng Yao*, Methylation of PhoP by CheR regulates Salmonella virulence, mBio. 2021 Sep 21; e0209921. doi: 10.1128/mBio.02099-21.
◆Su Y, Yang Y, Huang Y(*), Loss of ppr3, ppr4, ppr6 or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe, FEBS J, 2017, 284(2): 324-337.
◆ Su Y(#), Chen C(#), Huang L(#), Yan J, Huang Y(*), Schizosaccharomyces pombe Homologs of Human DJ-1 Are Stationary Phase Associated Proteins That Are Involved in Autophagy and Oxidative Stress Resistance, PloS One, 2015, 10(12): e0143888.
◆Zhao Q(#), Su Y(#), Wang Z(#), Chen C, Wu T, Huang Y(*), Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe, Bmc Evol Biol, 2014, 14: 86.
◆Su Y, Chen J, Huang Y(*), Disruption of ppr3, ppr4, ppr6, or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe, FEMS Microbiol Lett, 2018 Aug 1;365(16).
◆Ren J(#), Sang Y(#), Qin R, Su Y, Cui Z, Mang Z, Li H, Lu S, Zhang J, Cheng S, Liu X, Li J, Lu J, Wu W, Zhao GP, Shao F, Yao YF(*), Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation, Emerg Microbes Infect, 2019;8(1):55-69.
◆Rao F(*), Lin H, Su Y, Cullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and NewPhysiologic Players, Adv Exp Med Biol, 2020;1217:47-60.
◆Lin H(#), Zhang X(#), Liu L(#), Fu Q, Zang C, Ding Y, Su Y, Xu Z, He S, Yang X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T*, Rao F*, Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome, Proceedings of the National Academy of Sciences, 2020 Feb 25;117(8):4117-4124.
◆Xiaozhe Zhang, Shaodong Shi, Yang Su, Xiaoli Yang, Sining He, Jing Wu, Jian Zhang, Feng Rao*, Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat, J Biol Chem, 2020 Jun 3;jbc.RA120.014375.
◆Jianhui Li(#), Shuting Liu(#), Yang Su, Jie Ren, Yu Sang, Jinjing Ni, Jie Lu, Yu-Feng Yao*, Acetylation of PhoP K88 is involved in regulating Salmonella virulence, Infect Immun, 2020 Dec 14;IAI.00588-20.
◆Hong Lin(#), Yuan Yan(#), Yifan Luo(#), Wing Yan So(#), Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang & Feng Rao*, IP6 -assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion against hyperinsulinemia, Nature Communications, 2021 Apr 28;12(1):2461.
◆Yifan Luo, Yang Su & Feng Rao*, Role of NEDD8 and neddylation dynamics in DNA damage response, Genome Instability & Disease, 2021, volume 2, pages139–149.