Faculty
SELF-INTRODUCTION：
Yangpo Cao is the assistant professor and Ph.D supervisor of the Department of Pharmacology, School of Medicine, Southern University of Science and Technology. He graduated from Peking University in 2020 with a Doctoral degree of Philosophy and got Postdoctoral training at Boston Children's Hospital of Harvard Medical School from 2020 to 2023. In June 2023, he joined the Department of Pharmacology, School of Medicine, Southern University of Science and Technology. Dr. Cao has published many papers as first author (including co-first) in prestigious journals, including Circulation, Circulation Research, PNAS, Dev Cell, Cardiovasc Res. His lab mainly focuses on transcriptional regulation of cardiac development and diseases. Combining cutting-edge technology in molecular biology, cell biology and epigenetics, his lab studies the molecular mechanism of cardiac physiology and pathophysiology (cardiac hypertrophy, heart failure, atrial fibrillation, etc.) and development new therapeutic targets for cardiac diseases.
EDUCATION:
2009.09-2014.06 Northwest A&F University, Bachelor of Science in Agriculture
2014.09-2020.01 Peking University, Doctor of Philosophy
WOKRING EXPERIENCE:
2020.01-2023.03 Harvard Medical School/Boston Children’s Hospital, Research Fellow
2023.06-2023.11 Southern University of Science and Technology, Assistant Professor
2023.12-now Southern University of Science and Technology, Assistant Professor，Associate professor
HONORS AND AWARDS:
2018 Academic Innovation Award in Peking University
2019 Academic New Talent Award of School of Basic Medical Sciences, Peking University
2020 Outstanding Graduates of Beijing City
2020 Outstanding Graduates of Peking University
2020 Excellent Doctoral Dissertation in Peking University
2023 Talent title of state
Academic Appointments:
1. American Heart Association，Member
2. International Society for Heart Research，Member
3. Clinical and Basic Research Branch of the Guangdong-Hong Kong-Macao Greater Bay Area Cardiology Association, China，committee member
Research:
1. Mechanism of American Heart Association
2. Mitochondrial quality control and cardiac pathophysiology
3. Development of high-throughput technology for analysis of genes and non-coding regions
PUBLICATIONS：
Guo Y#, Cao Y#, Jardin BD#, Mazumdar N, Guo C, Yang L, Lin J, Zhan C, Ma Q, Zhao M, Dong E, Pu WT. A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation. Sci China Life Sci.2023 Dec;66(12):2939-2942. doi: 10.1007/s11427-023-2385-x. Epub 2023 Aug 11.
Sweat ME#, Cao Y#, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Song MK, Trembley MA, Wang P, Lu F, Gianeselli M, Prondzynski M, Bortolin RH, Seidman JG, Seidman CE, Moskowitz IP, Pu WT. Tbx5 maintains atrial identity by regulating an atrial enhancer network. Nat Cardiovasc Res. 2023 Oct;2(10):881-898. doi: 10.1038/s44161-023-00334-7. Epub 2023 Oct 12.
Feng Xiao#,Xiaoran Zhang#,Sarah U Morton#,Seong Won Kim,Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson,Neil Mazumdar,Yangpo Cao, Jian Chen,Jacob Hagen,Xujie Liu,Pingzhu Zhou,Felix Richter,Yufeng Shen,Tarsha Ward,Bruce D Gelb,Jonathan G Seidman,Christine E Seidman*,William T Pu*.Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease.Nat Genet. 2024 Feb 20. doi: 10.1038/s41588-024-01669-y. Online ahead of print.
Chaoshan Han#,Junjie Yang#,Tingting Yin#,Junqing An,Aijun Qiao, Yangpo Cao, Yuliang Feng,Haocheng Lu,Ying Wang,Liang Yang, Gangjian Qin*.CD63-snorkel tagging for isolation of exosomes.ScienceDirect.2023 October 26.doi: 10.1016/j.vesic.2023.100031
Zhou P#, VanDusen NJ#, Zhang Y#, Cao Y#, Sethi I, Hu R, Zhang S, Wang G, Ye L, Mazumdar N, Chen J, Zhang X, Guo Y, Li B, Ma Q, Lee JY, Gu W, Yuan GC, Ren B, Chen K*, Pu WT*. Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Dev Cell. 2023 May 22;58(10):898-914.e7
Cao Y#, Zhang X#, Akerberg BN#, Yuan H, Sakamoto T, Xiao F, VanDusen NJ, Zhou P, Sweat ME, Wang Y, Prondzynski M, Chen J, Zhang Y, Wang P, Kelly DP, Pu WT. In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. Circulation. 2023 Mar 14;147(11):881-896
Zhou P#, Zhang Y#, Sethi I, Ye L, Trembley MA, Cao Y, Akerberg BN, Xiao F, Zhang X, Li K, Jardin BD, Mazumdar N, Ma Q, He A, Zhou B, Pu WT. GATA4 Regulates Developing Endocardium Through Interaction With ETS1. Circ Res. 2022 Nov 11;131(11):e152-e168
Liu R, Xu C, Zhang W, Cao Y, Ye J, Li B, Jia S, Weng L, Liu Y, Liu L, Zheng M. FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia. Cell Death Dis. 2022 Jul 21;13(7):634
Guo Y#, Cao Y#, Jardin BD#, Zhang X, Zhou P, Guatimosim S, Lin J, Chen Z, Zhang Y, Mazumdar N, Lu F, Ma Q, Lu YW, Zhao M, Wang DZ, Dong E, Pu WT. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2023 Mar 17;119(1):221-235
Xu C, Cao Y, Liu R, Liu L, Zhang W, Fang X, Jia S, Ye J, Liu Y, Weng L, Qiao X, Li B, Zheng M. Mitophagy-regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction. J Cell Mol Med. 2022 Feb;26(4):1315-1326
Li B, Ye J, Liu R, Weng L, Cao Y, Jia S, Xu C, Liu Y, Yan S, Zheng M. Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2. Life Sci. 2021 Nov 15;285:119918
Guo Y#, Cao Y#, Jardin BD#, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N, Trembley MA, Small EM, Yuan GC, Beggs AH, Pu WT. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2008861118
Cao Y, Xu C, Ye J, He Q, Zhang X, Jia S, Qiao X, Zhang C, Liu R, Weng L, Liu Y, Liu L, Zheng M. Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction. Circ Res. 2019 Sep 27;125(8):728-743. doi: 10.1161/CIRCRESAHA.119.315432
Hu H, Jiang M, Cao Y, Zhang Z, Jiang B, Tian F, Feng J, Dou Y, Gorospe M, Zheng M, Zheng L, Yang Z, Wang W. HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling. Cardiovasc Res. 2020 Apr 1;116(5):944-955
Cao YP, Zheng M. Mitochondrial dynamics and inter-mitochondrial communication in the heart. Arch Biochem Biophys. 2019 Mar 15;663:214-219
Ye J, Zheng Q, Jia S, Qiao X, Cao Y, Xu C, Weng L, Zhao L, Chen Y, Liu J, Wang T, Cheng H, Zheng M. Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2a Protein. Hypertension. 2018 Oct;72(4):889-901
Weng L, Jia S, Xu C, Ye J, Cao Y, Liu Y, Zheng M. Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca2+ leakage channel Sec61α in mouse hearts. Cell Death Dis. 2018 May 23;9(6):612
Zhang CL, Chen ZJ, Feng H, Zhao Q, Cao YP, Li L, Wang JY, Zhang Y, Wu LL. C1q/tumor necrosis factor-related protein-3 enhances the contractility of cardiomyocyte by increasing calcium sensitivity. Cell Calcium. 2017 Sep;66:90-97
Qiao X, Jia S, Ye J, Fang X, Zhang C, Cao Y, Xu C, Zhao L, Zhu Y, Wang L, Zheng M. PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction. Sci Rep. 2017 Mar 27;7:45379
Jia S, Qiao X, Ye J, Fang X, Xu C, Cao Y, Zheng M. Nogo-C regulates cardiomyocyte apoptosis during mouse myocardial infarction. Cell Death Dis. 2016 Oct 20;7(10):e2432