Faculty
Self-introduction:
Dr Xiaotian Liu obtained his B.S. degree from USTC and Ph.D degree from HKUST.
He joined SUSTech since Sep. 2020, worked as Research Assistant Professor in Prof. Mingjie Zhang’s group in School of Life Science.
His research interest mainly focus on the structural and molecular basis of biological condensation formation.
Research Interests:
◆ Structural and functional study of protein machinery
◆ Molecular mechanism of biomolecular self-assembly
◆ Decoding and reprograming biological condensation formation
Educational Background：
Ph.D. in Bioengineering, Hong Kong University of Science and Technology 2015-2019
M.Phil. in Biochemistry, Hong Kong University of Science and Technology 2013-2015
B.Sc. in Biotechnology, University of Science and Technology of China 2003-2008
Honors & Awards：
Hong Kong Technology Talent Scheme Postdoctoral Hub for ITF 2020
Chan Tak Kei & Wong Kwai Ying Bioengineering Student Research Award 2019
HKJEBN Scholarship for Talents 2016-2019
Selected Publication：
1. Xinlin Hu#, Ping Yang#, Changdong Chai, Jia Liu, Huanhuan Sun, Yanan Wu, Mingjie Zhang, Min Zhang*, Xiaotian Liu* & Hongjun Yu*. (2023) “Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1” Nature. 616(7955):190-198.
2. Shuang Fu#, Wei Shi#, Tingdan Luo, Yingchuan He, Lulu Zhou, Jie Yang, Zhichao Yang, Jiadong Liu, Xiaotian Liu, Zhiyong Guo, Chengyu Yang, Chao Liu, Zhen-li Huang, Jonas Ries, Mingjie Zhang, Peng Xi, Dayong Jin & Yiming Li*. (2023) “Field-dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging” Nat Methods. 20(3):459-468.
3. Yanan Wu#, Min Zhang#, Yizheng Yang#, Xuyang Ding, Ping Yang, Kai Huang, Xinlin Hu, Mingjie Zhang, Xiaotian Liu* & Hongjun Yu*. (2022) “Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z” Cell Discov. 8(1): 129.
4. Bojing Jiang#, Xiaotian Liu#, Chao Yang#, Zhongguang Yang, Jiren Luo, Songzi Kou, Kai Liu, and Fei Sun*. (2020) “Injectable, photoresponsive hydrogels for axon regeneration enabled by metal-directed protein assembly” Science Advances. v. 6 (41): eabc4824.
5. Songzi Kou, Xin Yang, Zhongguang Yang, Xiaotian Liu, SV Wegner, Fei Sun*. (2019) “Cobalt-Cross-Linked, Redox-Responsive Spy Network Protein Hydrogels” ACS Macro Letters. 8(7):773-778.
6. Xiaotian Liu, Xin Yang, Zhongguang Yang, Jiren Luo, X Tian, Kai Liu, Songzi Kou, Fei Sun*. (2018) “Versatile engineered protein hydrogels enabling decoupled mechanical and biochemical tuning for cell adhesion and neurite growth” ACS Applied Nano Materials. 1(4):1579-1585.
7. A Tyagi, Xiaotian Liu, I Abidi, Z Gao, B Park, X Zeng, X Ou, A Cagang, M Zhuang, M Hossain, K Zhang, L Weng, F Sun, Z Luo*. (2018) “Modular functionalization of crystalline graphene by recombinant proteins: a nanoplatform for probing biomolecules” Nanoscale. 10(47):22572-22582.
8. Jiren Luo, Xiaotian Liu, Zhongguang Yang, Fei Sun*. (2018) “Synthesis of Entirely Protein-Based Hydrogels by Enzymatic Oxidation Enabling Water-Resistant Bioadhesion and Stem Cell Encapsulation”. ACS Applied Bio Materials. 1(5):1735-1740.
9. Wei Zhiyi#, Xu Zhiwen#, Liu Xiaotian, Lo WS, Ye F, Lau CF, Wang F, Zhou JJ, Nangle LA, Yang XL, Zhang Mingjie*, Schimmel P*. (2016) “Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase” Nucleic Acids Res. 44(3):1247-55.
10. Wei Zhiyi#, Liu Xiaotian#, Yu Cong, Zhang Mingjie*. (2013) “Structural basis of cargo recognitions for class V myosins” PNAS. 110(28):11314-9.
11. Wu Minhao#, Tao Yue#, Liu Xiaotian, Zang Jianye*. (2013) “Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli” JBC. 288(22):15878-87.
12. Liu Xiaotian, Wu Minhao, Sun Demeng, Zang Jianye*. (2010) “Cloning, purification, crystallization and preliminary crystallographic analysis of LsrR from Escherichia coli” Acta F. 66(Pt 8):913-5.
#Co-first author, *Correspondence