Faculty
Personal Profile
Wang Lin, male, M.D., is an associate professor, researcher, chief physician, doctoral supervisor of the School of Medicine of Southern University of Science and Technology, a B-grade talent of Shenzhen "Pengcheng Peacock Program", and a Research fellow of the Spine Surgery Center of Washington University School of Medicine in St. Louis, USA. He presided over 3 projects of National Natural Science Foundation, 1 project of Guangdong Natural Science Foundation and 1 project of Shenzhen Natural Science Foundation; Published 36 SCI papers and 42 core journal papers; It has been authorized 10 national invention patents and 4 utility model patents.
He has guided and trained nearly 20 doctoral and master's students in clinical medicine and biology, one of whom has been awarded the Changjiang Scholars of the Ministry of Education and many of whom have been funded by the National Natural Science Foundation. Served as academic tutor for nearly 20 undergraduate students majoring in clinical medicine and biomedical science, 2 of whom were funded by Shenzhen Medical Research Fund for Undergraduates, and many of whom were awarded national and provincial awards by the National College Students Basic Medical Innovation Research and Experimental Design Forum. Many of them were exempted from admission to Peking University Health Science Center, West China Medical College of Sichuan University, Xiangya Medical College of Central South University, Qilu Medical College of Shandong University and other well-known medical colleges in China for further study.
He is a well-known young and middle-aged expert in the field of spinal surgery and spinal deformities in China, and is good at the accurate surgical correction of complex spinal deformities in children and adults. In China, PVCR technology was used earlier to cure severe scoliosis and kyphosis, and the surgical correction rate, safety and long-term efficacy have reached the international advanced level. Long-term commitment to the clinical application of intelligent and digital technologies such as 3D printing, mixed reality navigation, surgical robots, and take the lead in exploring surgical practice: He has completed the first Mazor Renaissance robotic cervical spine surgery in China (2014), the first O-arm assisted Tianguet robotic spinal surgery in China (2019), and the first mixed reality (MR) navigated spinal surgery in the world (2019). He has successively served as a member of the Spine Surgery Expert Working Committee of the Orthopedic Surgeons Branch of the Chinese Medical Doctor Association, Deputy chairman of the Youth Working Committee of the Orthopedic Innovation and Transformation Branch of the Chinese Research Hospital Society, a member of the Training working group of the Orthopedic Professional Committee of the Chinese Medical Doctor Association, and the first chairman of the Intelligent and Digital Surgery Professional Committee of the Shenzhen Medical Doctor Association.
Research
1. The core mechanism of the steady state imbalance of glycolipid metabolism in the development of osteopathy
2. Microenvironment and biological behavior of the surface interface of bone implanted materials
3. Bone tissue engineering and regenerative medicine
Teaching
Lecture: Introduction to Bone and Joint Diseases (Postgraduate Course)
Intelligent Medicine (Graduate Program)
History of Medicine (Undergraduate program)
Professional Activities
1. Founding Member of Chinese Orthopaedic Elite Association (Spine Surgery)
2. Standing Member of the first Committee of Medical Artificial Intelligence Professional Committee of Chinese Hospital Association
3. Member of Digital Orthopaedics Group, Chinese Medical Association Society of Medical Engineering
4. Member of Information Construction Committee of China Orthopaedic College
5. Standing Member and Director General of the Intelligent and Digital Surgery Branch of the Chinese Geriatric Society
6. Member of the 20th Council of Guangdong Medical Association
7. Member of the fourth Council of Guangdong Rehabilitation Medical Association
8. Deputy Chairman of the first Committee of the Spine and Joint Health Branch of Guangdong Health Association
9. Standing Director of the third Council of Orthopedic Surgeons Branch of Shenzhen Medical Association
10. The second Chairman of the Professional Committee of Intelligent and Digital Surgery, Shenzhen Medical Association
Honors & Awards
1. Second Prize of Science and Technology Progress of Shandong Province (2011)
2. Completed the first large animal bone implantation experiment of 3D printed titanium alloy scaffold in China (2012)
3. Second Prize of Chinese Society of Osteology (COA) Young and Middle-aged Excellent Papers (2013)
4. Performed the first Mazor Renaissance robotic cervical spine surgery in China (2014)
5. Second Prize of Chinese Medical Science and Technology Award, Chinese Medical Association (2016)
6. Second Prize of Orthopaedic Standardized Surgery Video Competition of Chinese Medical Doctor Association Branch of Orthopaedic Surgeons (CAOS) (2017)
7. The first O-arm assisted Tianguet robot spinal surgery in China was completed by the main operator (2019)
8. Performed the world's first mixed reality (MR) guided spinal surgery (2019)
Education
1995-2000 Fourth Military Medical University, PLA, Bachelor of Medicine
2002-2005 PLA Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Master of Orthopaedics
2005-2008 PLA Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, MD&Ph.D
2012.1-8 Spinal Surgery Center, Washington University in St. Louis, School of Medicine, Research Fellow
Academic Appointments
2000-2008, Residency/Teaching Assistant, Department of Orthopaedic Surgery, Xijing Hospital，F(xiàn)ourth Military Medical University
2008-2016, Attending Surgeon/Instructor, Department of Orthopaedic Surgery, Xijing Hospital，F(xiàn)ourth Military Medical University
2016-2018.7, Attending Surgeon/Associate Professor, Department of Orthopaedic Surgery, the First Affiliated Hospital of Xi’an Jiaotong University
2018.7-2024.4, Attending Spinal Surgeon, Southern University of Science and Technology Hospital
2018.7-Now, Attending Associate Professor, School of Medicine, Southern University of Science and Technology
Peer-reviewed Publications
[1]Z. Wu, Q. Hou, H. Chi, J. Liu, Y. Mei, T. Chen, K. Yang, J. Zheng, J. Xu, F. Wei, and L. Wang, Single-cell RNA sequencing reveals a distinct profile of bone immune microenvironment and decreased osteoclast differentiation in type 2 diabetic mice. GENES & DISEASES 11 (2024).
[2] T. Chen, Z. Wu, Q. Hou, Y. Mei, K. Yang, J. Xu, and L. Wang, The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair. International Journal of Nanomedicine 19 (2024) 2709-2732.
[3] Z. Wu, Q. Hou, T. Chen, X. Jiang, L. Wang, J. Xu, and L. Wang, ROS-reactive PMS/PC drug delivery system improves new bone formation under diabetic conditions by promoting angiogenesis-osteogenesis coupling via down-regulating NOX2-ROS signalling axis. Biomaterials 293 (2023).
[4] L. Wang, M. Shen, Q. Hou, Z. Wu, J. Xu, and L. Wang, 3D printing of reduced glutathione grafted gelatine methacrylate hydrogel scaffold promotes diabetic bone regeneration by activating PI3K/Akt signaling pathway. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 222 (2022) 1175-1191.
[5] Z. Wang, T. Chen, Z. Wu, X. Jiang, Q. Hou, S. Miao, R. Xia, L. Wang, The dual-effects of PLGA@MT electrospun nanofiber coatings on promoting osteogenesis at the titanium-bone interface under diabetic conditions, Journal of Materials Chemistry B 10(21) (2022) 4020-4030.
[6] X.Y. Ma, T.C. Ma, Y.F. Feng, G. Xiang, W. Lei, D.P. Zhou, H.L. Yu, L.B. Xiang, L. Wang, Promotion of osteointegration under diabetic conditions by a silk fibroin coating on 3D-printed porous titanium implants via a ROS-mediated NF-kappaB pathway, Biomed Mater 16(3) (2021).
[7] X.F. Hu, Y.F. Feng, G. Xiang, W. Lei, L. Wang, Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone, Journal of Materials Chemistry B 6(15) (2018) 2274-2288.
[8] F. Wang, L. Wang, Y. Feng, X. Yang, Z. Ma, L. Shi, X. Ma, J. Wang, T. Ma, Z. Yang, X. Wen, Y. Zhang, W. Lei, Evaluation of an artificial vertebral body fabricated by a tantalum-coated porous titanium scaffold for lumbar vertebral defect repair in rabbits, Sci Rep 8(1) (2018) 8927.
[9] X.F. Hu, L. Wang, G. Xiang, W. Lei, Y.F. Feng, Angiogenesis impairment by the NADPH oxidase-triggered oxidative stress at the bone-implant interface: Critical mechanisms and therapeutic targets for implant failure under hyperglycemic conditions in diabetes, Acta biomaterialia 73 (2018) 470-487.
[10] X.F. Hu, L. Wang, Y.Z. Lu, G. Xiang, Z.X. Wu, Y.B. Yan, Y. Zhang, X. Zhao, Y. Zang, L. Shi, W. Lei, Y.F. Feng, Adiponectin improves the osteointegration of titanium implant under diabetic conditions by reversing mitochondrial dysfunction via the AMPK pathway in vivo and in vitro, Acta biomaterialia 61 (2017) 233-248.