Faculty
Shan Li is an Tenured Associate Professor and a Ph.D. superviser at the School of Medicine, Southern University of Science and Technology. She is a recipient of the National Natural Science Foundation of China’s Excellent Young Scientists Fund and the Hubei Provincial Outstanding Young Scientist Fund. Over the years, she has focused on researching the molecular mechanisms of pathogen infections and host immunity, with a particular emphasis on enteropathogenic Escherichia coli, Salmonella, and chromobacterium. Her work has uncovered various pathogen-host interaction mechanisms, including the mechanisms of bacterial infection, human host inflammatory responses and cell death, and phage infection-bacterial anti-phage mechanisms.
She has discovered and named two novel protein post-translational modifications (Arginine-GlcNAcylation and ADPR-Deacylization) and has developed the scientific chain from "novel discovery" to "molecular mechanism elucidation" to "research tool development and commercialization" for the arginine N-acetylglucosamine modification (Arginine-GlcNAcylation). Her related findings are included in the Textbook of Rheumatology (10th Edition) and have been translated into multiple languages. She has published over 20 papers in academic journals such as Nature, Molecular Cell (3 papers), Angewandte Chemie International Edition, Communications Biology, Apoptosis, Science of The Total Environment, Frontiers in Cell and Developmental Biology, Science, Cell, Cell Research, PNAS, JOC, Cell Host & Microbe, and Genes & Development, with a cumulative SCI impact factor exceeding 300, over 3000 citations according to Google Scholar, and an H-index of 16. She has led or participated in more than twenty projects, including the National Natural Science Foundation of China’s General Projects (2 projects), the Excellent Young Scientists Fund, the Ministry of Science and Technology's 13th and 14th Five-Year Key R&D Programs (2 projects), provincial education department innovation teams, and provincial outstanding youth projects. She has also guided team members in obtaining various national and youth project approvals.
EDUCATION:
2007-2013 | Ph.D. | Biochemistry and Molecular Biology, National Institute of Biological Sciences, Beijing., Supervisor: Prof. Feng Shao |
2003-2007 | B.S. | Biological Science, College of Biological Sciences, China Agricultural University, Supervisor: Prof. Yijun Qi |
2003-2007 | B.S. | Business Administration, Management of Biotech Companies, China Agricultural University, Supervisor: Prof. Xiurong He |
WOKRING EXPERIENCE:
2024-present | Tenured Associate Professor | Southern University of Science and technology(SUSTech) |
2018-2024 | Professor, PhD Supervisor | College of Life Science and Technology, Huazhong Agricultural University (HZAU) |
2014-2024 | Director | Institute of Infection and Immunity, Central Laboratory, Taihe Hospital, Hubei University of Medicine |
2013-2015 | Postdoctoral Fellow | National Institute of Biological Sciences, Beijing. |
2022-2024 | Deputy Director | Major Project Management Department, Institute of Scientific Development, HZAU |
2019-2024 | Secretary General | Ethics Committee, HZAU |
2018-2024 | Vice Chairman | Youth Federation, HZAU |
HONORS AND AWARDS:
2023 | Excellent Young Scholar, NSFC |
2020 | One hundred outstanding female scientific and technological innovation talents, Hubei Province |
2017 | Chutian Scholar, Hubei Province |
2016 | Natural Science Outstanding Paper Award, Hubei province |
2015 | Distinguished Young Scholar, Hubei Province |
2015 | Outstanding Young Talents, Hubei Health Commission |
2013 | Ray Wu Prize, Ray Wu Memorial Foundation |
RESEARCH:
Mechanism of Pathogen-Host interactions
including bacterial pathogen-human/animal host, phage pathogen-bacterial host
Identification of New Post-translational modification
Mechanism of programmed cell death
MANUSCRIPT REVIEWER AND EDITOR：
2020-present | Associate Editor | Frontiers in Cell and Developmental biology |
2023-present | Youth Editor | hLife |
2017-present | Reviewer | Molecular Cell, Nature Communications, Cellular Microbiology, PLOS Pathogens, Science China etc. |
2018-present | Review Expert | NSFC, Science and Technology Departments of Hubei, Jiangxi, Yunnan provinces |
PUBLICATIONS：
1. Liu S, Ma L, Lv R, Pan X, Hu S, Li S#. (2024) The bacterial T3SS effector CipB family is an exogenous mitophagy receptor to trigger mitophagy-TFEB axis and promote pathogenesis. Molecular Cell Under Review
2. Meng K, Yang J, Shi L, Lv J, Li S#. (2023) A host E3 ubiquitin ligase regulates Salmonella virulence by targeting an SPI-2 effector involved in SIF biogenesis. mLife
3. Zhang K*, Peng T*, Tao X*, Tian M*, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, FuY#, Li S#. (2022) Structural insights into caspase ADPR-deacylization catalyzed by a bacterial effector and host calmodulin. Molecular Cell
4. Peng T*, Tao X*, Xia Z, Hu S, Xue J, Zhu Q, Pan X, Zhang Q, Li S. (2022) Pathogen Hijacks Programmed Cell Death Signaling by Arginine ADPR-Deacylization of Caspases. Molecular Cell.
5. Meng K, Zhu P, Shi L, Li S#.(2023)Determination of the Salmonella intracellular lifestyle by the diversified interaction of Type III secretion system effectors and host GTPases. WIREs Mechanism of Disease.
6. Ding J#, Yao Q, Li L, Dong N, Li S#, Shao F#. (2019) Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector. Molecular Cell
7. Liu W, Tang Q, Meng L, Hu S, Sun E, Li S, Dai P#,Chen X#. (2023) Interbacterial Chemical Communication-Triggered Nascent Proteomics.Angewandte chemie International Edition.
8. Xue J, Huang Y, Zhang H, Hu J, Pan X, Peng T, Lv J, Meng K, Li S#. (2022) Arginine Glcnacylation and Activity Regulation of Phop by a Type Iii Secretion System Effector in Salmonella. Frontiers in Microbiology.
9. Meng K*, Zhang X*, Peng T*, Yang J, Liu X, Shao F, Li S#. (2020) Arginine GlcNAcylation of Rab small GTPases by the pathogen Salmonella Typhimurium. Communications Biology.
10. Lv J*，Yang J*，Xue J，Li S#. (2020) Detection of SARS-CoV-2 RNA residue on object surfaces in nucleic acid testing laboratory using droplet digital PCR. Science of The Total Environment
11. Lv J, Yang J, Xue J, Zhu P, Liu L, Li S#. (2021) Investigation of potential safety hazards during medical waste disposal in SARS-CoV-2 testing laboratory. Environmental Science and Pollution Research
12. Xue J*, Pan X*, Peng T, Duan M, Du L, Zhuang X, Cai X, Yi X, Fu Y, Li S#. (2020) Auto arginine-GlcNAcylation is crucial for bacterial pathogens in regulating host cell death. Frontiers in Cellular infection and Microbiology
13. Pan X*, Luo J*, Li S#.(2020) Bacteria-catalyzed arginine glycosylation in pathogens and host; Frontiers in Cellular infection and Microbiology
14. Xue J, Hu S, Huang Y, Yi X, Zhang Q, Li S#. (2020) Arg-GlcNAcylation of TRADD by NleB and SseK1 is crucial for bacterial pathogenesis. Frontiers in Cell and Developmental Biology
15. Luo J, Hu J, Zhang Y, Hu Q and Li S#. (2015) Hijacking of death receptor signaling by bacterial pathogen effectors. Apoptosis 20:216-223
16. Lu Q, Li S, and Shao F. (2015) Sweet talk: protein glycosylation in bacterial interaction with the host. Trends in microbiology 23(10):630-641.
17. Li S*, Zhang L*, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S?, Shao F?. (2013) Pathogen blocks host death receptor signaling by arginine GlcNAcylation of death domains. Nature. 501 (7466):242-6.
18. Pan M*, Li S*,Li X, Shao F, Liu L, and Hu H. (2014) Synthesis and Specific Antibody generation of Glycopeptides with Arginine N-GlcNAcylation. Angewandte Chemie International Edition 53（52）：14517-14521
19. Lu Q, Yao Q, Xu Y, Li L, Li S, Liu Y, Gao W, Niu M, Sharon M, Ben-Nissan G, Zamyatina A, Liu X, Chen S, Shao F (2014) An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis. Cell host & microbe 16 (3):351-363.
20. Li C, Tu S, Wen S, Li S, Chang J, Shao F, Lei X. (2011) Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C. The Journal of Organic Chemistry, 76（9）, 3566-70.
21. Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F. (2010) Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science, 329, 1215-8.
22. Gong YN, Wang X, Wang J, Yang Z, Li S, Yang J, Liu L, Lei X, Shao F. (2010) Chemical probing reveals insights into the signaling mechanism of inflammasome activation. Cell Research, 20, 1289-305.
23. Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F. (2009) A Legionella type IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors. Proc. Natl. Acad. Sci., 106, 13725-30.
24. Wei B, Cai T, Zhang R, Li A, Huo N, Li S, Gu YQ, Vogel J, Jia J, Qi Y, Mao L. (2009) Novel microRNAs uncovered by deep sequencing of small RNA transcriptomes in bread wheat (Triticum aestivum L.) and Brachypodium distachyon (L.) Beauv. Funct Integr Genomics., 9, 499-511.
25. Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L, Li S, Zhou H, Long C, Chen S, Hannon G, Qi Y. (2008) Sorting of small RNAs into Arabidopsis Argonaute complexes is directed by the 5’ terminal nucleotide. Cell, 133: 116-127.
26. Zhao T, Li G, Mi S, Li S, Hannon G, Wang XJ*, Qi Y.* (2007). A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes and Development, 29, 1190-1203.