Dr. Chuan He, Associate Professor, PI. National Distinguished Young Expert, NSFC Outstanding Young Scholar, Guangdong Province Pearl River Youth Talent, Shenzhen Overseas High-Level Talent, Shenzhen Excellent Science and Technology Innovation Distinguished Young Scholar.
2004-2008, B.S., Wuhan University, China
2008-2013, Ph.D., Wuhan University, China, Supervisor: Prof. Aiwen Lei
2013-2017, Postdoc (Marie Curie Research Fellow), University of Cambridge, Supervisor: Prof. Matthew Gaunt
2018-present, Associate Professor, PI, Southern University of Science and Technology
Research Interests:
Chiral Organosilicon Chemistry
Chiral Organoboron Chemistry
Chiral Organic Functional Materials
We are always looking for talented, self-motivated and creative individuals with interests in any of the following areas: transition metal catalysis, asymmetric catalysis, organo-material chemistry. If you are interested in joining the group, please contact me directly.
Representative Publications
(1)Ren, L-Q.; Zhan, B.; Zhao, J.; Guo, Y.; Zu, B.; Li, Y.; He, C.* Modular Enantioselective Assembly of Multi-Substituted Boron-Stereogenic BODIPYs, Nat. Chem. 2025, 17, 83?91.
(2)Ge, Y.; Ke, J.; He, C.* Catalytic Asymmetric Dehydrogenative Si?H/X?H Coupling toward Si-Stereogenic Silanes, Acc. Chem. Res. 2025, 58, 375?398.
(3)Zhan, B.; Ren, L-Q.; Zhao, J.; Zhang, H.;* He, C.* Catalytic Asymmetric C–N Cross-Coupling towards Boron-Stereogenic 3-Amino-BODIPYs, Nat. Commun. 2025, 16, 438.
(4)Lin, W.; Ren, L-Q.; Chen, C. D.; Han, X.; Zhang, L.; Chen, Z.; Guo, J.;* He, C.* Cu-Catalyzed Asymmetric Hydrogermylation towards C- and Ge-Stereogenic Germanes, CCS Chem. 2025, 7, 1157?1167.
(5)Wu, L.; Zhang, L.; Guo, J.; Gao, J.; Ding, Y.; Ke, J.;* He, C.* Catalytic Asymmetric Construction of C- and Si-Stereogenic Silacyclopentanes via Hydrosilylation of Arylmethylenecyclopropanes, Angew. Chem., Int. Ed. 2024, 63, e202413753.
(6)Gao, J.; Ge, Y.;* He, C.* X-Type Silyl Ligands for Transition-Metal Catalysis, Chem. Soc. Rev. 2024, 53, 4648?4673.
(7)Yang, B.; Gao, J.; Tan, X.; Ge, Y.;* He, C.* Chiral PSiSi-Ligand Enabled Iridium-Catalyzed Atroposelective Intermolecular C?H Silylation, Angew. Chem., Int. Ed. 2023, 62, e202307812.
(8)Liu, M.-M.; Xu, Y.; He, C.* Catalytic Asymmetric Dehydrogenative Si?H/N?H Coupling: Synthesis of Silicon-Stereogenic Silazanes, J. Am. Chem. Soc. 2023, 145, 11727?11734.
(9)Zu, B.; Guo, Y.; Ren, L-Q.; Li, Y.;* He, C.* Catalytic Enantioselective Synthesis of Boron-Stereogenic BODIPYs, Nat. Synth. 2023, 2, 564?571.
(10)Yuan, W.; Zhu, X.; Xu, Y.; He, C.* Synthesis of Si-Stereogenic Silanols by Catalytic Asymmetric Hydrolytic Oxidation, Angew. Chem., Int. Ed. 2022, 61, e202204912.
(11)Chen, S.; Zhu, J.; Ke, J.; Li, Y.; He, C.* Enantioselective Intermolecular C?H Silylation of Heteroarenes for the Synthesis of Acyclic Si-Stereogenic Silanes, Angew. Chem., Int. Ed. 2022, 61, e202117820.
(12)Zu, B.; Guo, Y.; He, C.* Catalytic Enantioselective Construction of Chiroptical Boron-Stereogenic Compounds, J. Am. Chem. Soc. 2021, 143, 16302?16310.
(13)Guo, Y.; Liu, M.-M.; Zhu, X.; Zhu, L.; He, C.* Catalytic Asymmetric Synthesis of Silicon-Stereogenic Dihydrodibenzosilines: Silicon-Central to Axial Chirality Relay, Angew. Chem., Int. Ed. 2021, 60, 13887?13891.
(14)Zhu, J.; Chen, S.; He, C.* Catalytic Enantioselective Dehydrogenative Si?O Coupling to Access Chiroptical Silicon-Stereogenic Siloxanes and Alkoxysilanes, J. Am. Chem. Soc. 2021, 143, 5301?5307.
(15)Ke, J.; Liu, W.; Zhu, X.; Tan, X.; He, C.* Electrochemical Radical Silyl-Oxygenation of Activated Alkenes, Angew. Chem., Int. Ed. 2021, 60, 8744?8749.
(16)Chen, S.; Mu, D.; Mai, P-L.; Ke, J.; Li, Y.; He, C.* Enantioselective Construction of Six- and Seven-Membered Triorgano-Substituted Silicon-Stereogenic Heterocycles, Nat. Commun. 2021, 12, 1249.
(17)Yang, B.; Yang, W.; Guo, Y.; You, L.; He, C.* Enantioselective Silylation of Aliphatic C?H Bonds for the Synthesis of Silicon-Stereogenic Dihydrobenzosiloles, Angew. Chem., Int. Ed. 2020, 59, 22217?22222.
Mu, D.; Yuan, W.; Chen, S.; Wang, N.; Yang, B.; You, L.; Zu, B.; Yu, P.; He, C.* Streamlined Construction of Silicon-Stereogenic Silanes by Tandem Enantioselective C?H Silylation/Alkene Hydrosilylation, J. Am. Chem. Soc. 2020, 142, 13459?13468.
