Self-introduction
My research mainly focuses on the structure and function of synaptic GTPase regulatory proteins and key proteins and protein complexes in inhibitory synaptic postsynaptic density.
Research Interests
1. Molecular mechanisms of dynamic assembly and phase separation regulation of the inhibitory postsynaptic density protein complex.
2. Mechanisms of Small G proteins and their regulatory factors in synaptic formation and plasticity regulation.
Professional Experience
2021/08-2023/07 SUSTech School of Life Sciences Postdoc
2023/08-2024/09 SUSTech School of Life Sciences Senior scientist
Educational Background
2016/09-2021/06 The Hong Kong University of Science and Technology Life science PH.D
2012/09-2016/06 University of Science and Technology of China Biology Bachelor
Selected Publication
1. Guanhua Bai, Yu Wang, and Mingjie Zhang*, "Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation," Cell Res, vol. 31, pp. 312-325, Mar 2021.
2. Guanhua Bai#, Hao Li#, Pengwei Qin, Yiqing Guo, Wanfa Yang, Yinmiao Lian, Fei Ye, Jianxin Chen, Meiling Wu, Ruifeng Huang, Jinsong Li, Youming Lu, Mingjie Zhang*,"Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under physiological and pathological conditions," J Cell Biol, vol. 222, Dec 4 2023.
3. Guanhua Bai and Mingjie Zhang*, "Inhibitory postsynaptic density from the lens of phase separation," Oxford Open Neuroscience, vol. 1, 2022.
4. Guanhua Bai and Mingjie Zhang*, "Mesophasic Assembly of Inhibitory Postsynaptic Density," Neurosci Bull, vol. 37, pp. 141-143, Jan 2021.
5. Guanhua Bai and Mingjie Zhang*, "Clustering acetylcholine receptors in neuromuscular junction by phase-separated Rapsn condensates," Neuron, vol. 109, pp. 1907-1909, Jun 16 2021.
6. Menglong Zeng, Guanhua Bai, and Mingjie Zhang*, "Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation," Small GTPases, vol. 10, pp. 296-304, Jul 2019.
