Faculty
Professional Experience
2016-present: Chair professor, Department of Biology, Southern University of Science and Technology of China
2015-2016: Full professor (W3), Max-Delbrueck-Center for Molecular Medicine jointly with Charité – Universit?tsmedizin Berlin
2009-2015: Group Leader, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany (Tenured since 2011)
2007-2009: Group Leader, MPI for Molecular Genetics, Berlin, Germany
Educational Background
Ph.D. MPI for Molecular Genetics 2002-2006
M.S. Sichuan University 1999-2002
B.S. Xiamen University 1989-1993
Honors & Awards
Selected Publication
◆Hou J, Wang X, McShane E, Zauber H, Sun W, Selbach M, Chen W. Extensive allele-specific translational regulation in hybrid mice. Mol Syst Biol. 2015 Aug 7;11(8):825. doi: 10.15252/msb.156240.
◆Gao Q, Sun W, Ballegeer M, Libert C, Chen W.Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing. Mol Syst Biol. 2015 Jul 1;11(7):816. doi: 10.15252/msb.20145970.
◆You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci. 2015 Feb 25. doi: 10.1038/nn.3975. [Epub ahead of print]
◆Wang, Y., Gogol-D?ring, A., Hu, H., Fr?hler, S., Ma, Y., Jens, M., Maaskola, J., Murakawa, Y., Quedenau, C., Landthaler, M., Kalscheuer, V., Wieczorek, D., Wang, Y., Hu, Y. and Chen, W (2013) Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Mol Med. 2013 doi: 10.1002/emmm.201302663
◆Sun W, You X, Gogol-D?ring A, He H, Kise Y, Sohn M, Chen T, Klebes A, Schmucker D, Chen W (2013) Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing. EMBO J. 2013 Jun 21. doi: 10.1038/emboj.2013.144. [Epub ahead of print]
◆Li N, You X, Chen T, Mackowiak SD, Friedl?nder MR, Weigt M, Du H, Gogol-D?ring A, Chang Z, Dieterich C, Hu Y, Chen W (2013) Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery. Nucleic Acids Res. 2013 Feb 8. [Epub ahead of print]
◆Mazin P, Xiong J, Liu X, Yan Z, Zhang X, Li M, He L, Somel M, Yuan Y, Phoebe Chen YP, Li N, Hu Y, Fu N, Ning Z, Zeng R, Yang H, Chen W*, Gelfand M*, Khaitovich P*.(2013) Widespread splicing changes in human brain development and aging. Mol Syst Biol. 2013 Jan 22;9:633.
◆Doering A & Chen W (2012) An overview of the analysis of next generation sequencing data. Methods Mol Biol. 802:249-57
◆Yan Z, Hu HY, Jiang X, Maierhofer V, Neb E, He L, Hu Y, Hu H, Li N, Chen W*, Khaitovich P* (2011) Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Res. 2011 Aug;39(15):6596-607
◆Schwanh?usser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J*, Chen W*, Selbach M*. (2011) Global quantification of mammalian gene expression control Nature. 2011 May 19;473(7347):337-42
◆Adamidi C, Wang Y, Gruen D, Mastrobuoni G, You X, Tolle D, Dodt M, Mackowiak SD, Gogol-Doering A, Oenal P, Rybak A, Ross E, Alvarado AS, Kempa S*, Dieterich C*, Rajewsky N*, Chen W * (2011) De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res 21(7):1193-200
◆Somel M*, Guo S, Fu N, Yan Z, Hu HY, Xu Y, Yuan Y, Ning Z, Hu Y, Menzel C, Hu H, Lachmann M, Zeng R, Chen W*, Khaitovich P*. (2010) MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res. 20(9):1207-18
◆Xu AG, He L, Li Z, Xu Y, Li M, Fu X, Yan Z, Yuan Y, Menzel C, Li N, Somel M, Hu H, Chen W*, P??bo S*, Khaitovich P*. (2010) Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq. PLoS Comput Biol. 6:e1000843.
◆Hu H, Wrogemann K, Kalscheuer V, Tzschach A, Richard H, Haas SA, Menzel C, Bienek M, Froyen G, Raynaud M, Van Bokhoven H, Chelly J, Ropers H, Chen W. (2010) Mutation screening in 86 known X-linked mental retardation genes by droplet-based multiplex PCR and massive parallel sequencing. The HUGO Journal: Volume 3, Issue 1, Page 41.
◆Kuss AW, Chen W (2008) MicorRNAs in brain function and disease. Curr Neurol Neurosci Rep. 8(3):190-7.
◆Chen W, Kalscheu V, Tzschach A, Menzel C, Ullmann R, Schulz M, Erdogan F, Li N, Kijas Z, Arkesteijn G, Pajares IL, Goetz-Sothmann M, Heinrich U, Rost I, Dufke A, Grasshoff U, Glaeser BG, Vingron M, Ropers HH. (2008) Mapping translocation breakpoints by next-generation sequencing. Genome Res. 18(7):1143-9